Elemental Chemometrics as Tools to Depict Stalked Barnacle (Pollicipes pollicipes) Harvest Locations and Food Safety

The stalked barnacle Pollicipes pollicipes is an abundant species on the very exposed rocky shore habitats of the Spanish and Portuguese coasts, constituting also an important economical resource, as a seafood item with high commercial value. Twenty-four elements were measured by untargeted total reflection X-ray fluorescence spectroscopy (TXRF) in the edible peduncle of stalked barnacles sampled in six sites along the Portuguese western coast, comprising a total of 90 individuals. The elemental profile of 90 individuals originated from several geographical sites (N = 15 per site), were analysed using several chemometric multivariate approaches (variable in importance partial least square discriminant analysis (VIP-PLS-DA), stepwise linear discriminant analysis (S-LDA), linear discriminant analysis (LDA), random forests (RF) and canonical analysis of principal components (CAP)), to evaluate the ability of each approach to trace the geographical origin of the animals collected. As a suspension feeder, this species introduces a high degree of background noise, leading to a comparatively lower classification of the chemometric approaches based on the complete elemental profile of the peduncle (canonical analysis of principal components and linear discriminant analysis). The application of variable selection approaches such as the VIP-PLS-DA and S-LDA significantly increased the classification accuracy (77.8% and 84.4%, respectively) of the samples according to their harvesting area, while reducing the number of elements needed for this classification, and thus the background noise. Moreover, the selected elements are similar to those selected by other random and non-random approaches, reinforcing the reliability of this selection. This untargeted analytical procedure also allowed to depict the degree of risk, in terms of human consumption of these animals, highlighting the geographical areas where these delicacies presented lower values for critical elements compared to the standard thresholds for human consumption.     

Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System

Ligands of the G_i protein-coupled adenosine A₃ receptor (A₃R) are receiving increasing interest as attractive therapeutic tools for the treatment of a number of pathological conditions of the central and peripheral nervous systems (CNS and PNS, respectively). Their safe pharmacological profiles emerging from clinical trials on different pathologies (e.g., rheumatoid arthritis, psoriasis and fatty liver diseases) confer a realistic translational potential to these compounds, thus encouraging the investigation of highly selective agonists and antagonists of A₃R. The present review summarizes information on the effect of latest-generation A₃R ligands, not yet available in commerce, obtained by using different in vitro and in vivo models of various PNS- or CNS-related disorders. This review places particular focus on brain ischemia insults and colitis, where the prototypical A₃R agonist, Cl-IB-MECA, and antagonist, MRS1523, have been used in research studies as reference compounds to explore the effects of latest-generation ligands on this receptor. The advantages and weaknesses of these compounds in terms of therapeutic potential are discussed.     

Two-gap superconductivity in the Fe-1111 superconductor LaFeAsO1−x F x : A point-contact Andreev-reflection study

Point-contact Andreev-reflection (PCAR) experiments were performed in the Fe-1111 layered superconductor LaFeAsO_0.9F_0.1 with resistive T _c ^on ∼ 27 K. The observation of two pairs of peaks in the low-temperature Andreev-reflection spectra clearly indicates the presence of two order parameters. The behavior of the two gaps as a function of temperature, obtained by fitting the conductance curves by means of the generalized two-band Blonder-Tinkham-Klapwijk model, shows some anomalies. A theoretical analysis performed within the two-band Eliashberg theory with a generic electron-boson coupling can reproduce the low-temperature value of the two gaps but generally fails in giving a satisfactory fit of their overall temperature dependence, indicating the rich and complex physics of these newly discovered superconductors.      

Computation of weak steady shock reflections by means of an unstructured shock-fitting solver

Weak steady Mach reflections are numerically simulated using unstructured grids by means of either “shock-fitting” or “shock-capturing” techniques. It is shown that shock-fitting allows using coarser meshes than those required by shock-capturing, since the latter needs mesh refinement in the direction normal to the discontinuities, which is not needed using the former approach. The shock-fitted solution is also free from the numerical disturbances that arise along the captured discontinuities and pollute the captured solution in the smooth flowfield region. Finally, the shock-fitting solutions show the presence of a small region next to the Mach stem and the reflected shock downstream of the triple point, characterized by very high gradients.     

Maximum stable set formulations and heuristics based on continuous optimization

 The stability number α(G) for a given graph G is the size of a maximum stable set in G. The Lovász theta number provides an upper bound on α(G) and can be computed in polynomial time as the optimal value of the Lovász semidefinite program. In this paper, we show that restricting the matrix variable in the Lovász semidefinite program to be rank-one and rank-two, respectively, yields a pair of continuous, nonlinear optimization problems each having the global optimal value α(G). We propose heuristics for obtaining large stable sets in G based on these new formulations and present computational results indicating the effectiveness of the heuristics. Received: December 13, 2000 / Accepted: September 3, 2002 Published online: December 19, 2002 RID="★" ID="★" Computational results reported in this paper were obtained on an SGI Origin2000 computer at Rice University acquired in part with support from NSF Grant DMS-9872009. Key Words. maximum stable set – maximum clique – minimum vertex cover – semidefinite program – semidefinite relaxation – continuous optimization heuristics – nonlinear programming Mathematics Subject Classification (2000): 90C06, 90C27, 90C30     

Beta-functionalised polythiophenes as microelectrode modifiers in low conductive media

A study on polythiophene coated microelectrodes is reported, the goal being that of checking the capability of these electrochemical systems to work in low conductive media. The possibility of electrochemically p-doping the polymer in the presence of very low concentrations or even in the absence of supporting electrolyte in the solution is ascertained, opening the way to the use of similar systems in pure solvent media. This result is obtained in such conditions that the presence of residual charges--and corresponding counterions--trapped inside the film coating can be reasonably hypothesised.     

Concise preparation of amino-5,6,7,8-tetrahydroquinolines and amino-5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of acetamidoquinolines and acetamidoisoquinolines

A method to prepare amino-substituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The yields of the products are good when the acetamido substituent is present on the pyridine ring and moderate with the acetamido substituent on the benzene ring. This method has also been applied to the regioselective reduction of quinoline substrates bearing other substituents (R = OMe, CO(2)Me, Ph).     

Irreducibility and simplicity in general algebrae and congruences in relatively complemented lattices

Summary Within a framework of general algebra we firstly formulate propositions concerning the connection between irreducibility, id est the absence of certain types of subalgebrae, and simplicity. Then we investigate some uniqueness properties of the congruences of certain types of lattices and we apply the general propositions to algebrae with lattice operations obtaining sufficient conditions for the simplicity of wide classes of such algebrae.

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Riassunto In un contesto di algebra generale noi formuliamo dapprima proposizioni concernenti la connessione tra irriducibilità, cioè l’assenza di certi tipi di sottoalgebre, e semplicità. In seguito investighiamo alcune proprietà di unicità delle conseguenze di certi tipi di reticoli e applichiamo le proposizioni generali ad algebre con operazioni di reticolo ottenendo condizioni sufficienti per la semplicità di ampie classi di tali algebre.