排序方式: 共有54条查询结果,搜索用时 15 毫秒
51.
M. Mahkam Reihaneh Mohammadi M. G. Assadi S. O. Ranaei-Siadat M. Barshan S. E. Ranaei-Siadat 《Silicon Chemistry》2006,3(1-2):51-58
A series of acrylic terpolymers containing silyl pendant groups was prepared by free radical cross-linking copolymerization. Me3Si, Et3Si and t-BuMe2Si together with cubane-1, 4-dicarboxylic acid (CDA) were covalently linked with 2-hydroxyethyl methacrylate (HEMA). The silyl-linked HEMA are abbreviated as TMSiEMA, TESiEMA and TBSiEMA respectively. Cubane-1, 4-dicarboxylic acid (CDA) linked to two HEMA group is the cross-linking agent (CA). Free radical cross-linking terpolymerization of the methyl methacrylate (MMA) and methacrylic acid (MAA) with two different molar ratios of organosilyl monomers and CA was carried out at 60–70 ∘C. The compositions of the cross-linked three-dimensional polymers were determined by FT-IR spectroscopy. The glass transition temperature (Tg) of the network polymers was determined calorimetrically. The Tg of network terpolymers increases with increasing of cross-linking degree. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The gels swelled more in SIF than in SGF. The swelling behaviour of the copolymers was dependent on the content of MAA groups and caused a decrease in gel swelling in pH 1 or an increase in gel swelling in pH 7.4. Based on the great difference in swelling ratio at pH 1 and 7.4 for P-1, P-6 and P-10 appear to be good candidates for colon-specific drug delivery. 相似文献
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53.
Mohammad Bagher Teimouri Reihaneh Bazhrang 《Monatshefte für Chemie / Chemical Monthly》2008,15(1):957-961
An efficient and clean green synthesis of highly substituted linear naphtho[2,3-b]-furan-4,9-dione derivatives, starting from 2-hydroxy-1,4-naphthoquinone, alkyl isocyanides and a variety of aldehydes, is
described. This new method provides the first example of an efficient regioselective synthetic method for the synthesis of
linear naphtho[2,3-b]-furan-4,9-dione ring systems by formation of three bonds. This [3 + 1 + 1] furannulation strategy affords furanonaphthoquinones
in moderate to high yields, using water as a cheap, non-toxic, environmentally friendly solvent, in a one-step reaction, without
the need of complicated work-up procedures. 相似文献
54.
Fatemeh Zehtabi Hossein Montazerian Reihaneh Haghniaz Kaylee Tseng Neda Mohaghegh Kalpana Mandal Behnam Zamanian Mehmet Remzi Dokmeci Mohsen Akbari Alireza Hassani Najafabadi Han-Jun Kim Ali Khademhosseini 《Macromolecular bioscience》2023,23(1):2200333
Shear-thinning biomaterials (STBs) based on gelatin-silicate nanoplatelets (SNs) are emerging as an alternative to conventional coiling and clipping techniques in the treatment of vascular anomalies. Improvements in the cohesion of STB hydrogels pave the way toward their translational application in minimally invasive therapies such as endovascular embolization repair. In the present study, sodium phytate (Phyt) additives are used to tune the electrostatic network of SNs-gelatin STBs, thereby promoting their mechanical integrity and facilitating injectability through standard catheters. We show that an optimized amount of Phyt enhances storage modulus by approximately one order of magnitude and reduces injection force by ≈58% without compromising biocompatibility and hydrogel wet stability. The Phyt additives are found to decrease the immune responses induced by SNs. In vitro embolization experiments suggest a significantly lower rate of failure in Phyt-incorporated STBs than in control groups. Furthermore, the addition of Phyt leads to accelerated blood coagulation (reduces clotting time by ≈45% compared to controls) due to the contributions of negatively charged phosphate groups, which aid in the prolonged durability of STB in coagulopathic patients. Therefore, the proposed approach is an effective method for the design of robust and injectable STBs for minimally invasive treatment of vascular malformations. 相似文献