Syntheses,Reactions, Characterization,and Antifungal Activities of Chloro-bis-(2,2-dithio-1,3,2-dioxaphospholane/dioxaphosphorinane)bismuth(III)

Abstract

Chloro-bis(2,2-dithio-1,3,2-dioxaphospholane/dioxaphosphorinane)bismuth(III) compounds have been synthesized by the reaction of bismuth trichloride with sodium 2,2-dithio-1,3,2-dioxaphospholane/dioxaphosphorinane in 1:2 molar ratio in benzene solution. Reactions of these chloro-bis(2,2-dithio-1,3,2-dioxaphospholane/dioxaphosphorinane)-bismuth(III) compounds with sodium tetraisopropoxyborate in equimolar ratio in benzene solution yield the corresponding heterobinuclear bismuth derivatives with boron. All compounds were characterized by elemental analyses and molecular weight measurements. Plausible structures are proposed on the basis of IR and ¹H, ¹¹B, ¹³C, and ³¹P spectroscopic studies. 2-Mercapto-2-thioxo-1,3,2-dioxaphospholanes-/dioxaphosphorinanes and the corresponding chloro-bis(2,2-dithio-1,3,2-dioxaphospholane/dioxaphosphorinane)bismuth (III) compounds show antifungal activities against Fusarium and Trichoderma.

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GRAPHICAL ABSTRACT      

A thermal behaviour and structural study of bis(hydroxamato)oxovanadium(IV) complexes

The bis(hydroxamato)oxovanadium(IV) complexes of composition [VO(IAH)₂)] (I), [VO(IBH)₂)] (II) and [VO(ICH)₂)] (III) (where IAH = indole-3-acetohydroxamate; (C₉H₈NCONHO^?); IBH = indole-3-butyrohydroxamate; (C₁₁H₁₂NCONHO^?); ICH = indole-2-carbohydroxamate; (C₈H₆NCONHO^?)) synthesized form the reactions of VOSO₄·5H₂O with bi-molar amounts of potassium salts of the respective hydroxamic acids in methanol have been characterised by elemental analyses, magnetic moment measurements and IR spectral studies. The thermal behaviour of complexes has been studied by TG and DTA techniques. Thermograms indicated that all complexes decompose in two steps yielding [VO(IAH)], [VO(IBH)] and [VO(ICH)] as intermediate of respective complexes and VO₂ as the final product of decomposition in each case. From the initial decomposition temperatures (IDT), the order of thermal stability for the complexes has been inferred as II > I > III.     

Synthesis and spectroscopic analysis of a stereoisomer library of the phytophthora mating hormone α1 and derived bis-Mosher esters

Fluorous mixture synthesis provided all eight diastereomers of the phytophthora hormone α1 with the R configuration at C11 as individual samples after demixing and detagging. The library of all possible bis-Mosher esters (16) was then made by esterification. Complete sets of (1)H, (13)C, and (for the Mosher esters) (19)F NMR spectra were recorded, assigned, and compared with each other and with published spectra. Not all of the spectra are unique, and the (1)H NMR spectra of the Mosher esters provided the most information. The previous assignment of the natural sample as an "all-R" stereoisomer mixed with its 3S-epimer was confirmed.     

Amberlyst-15–Catalyzed Efficient Cyclization of γ- and δ-Unsaturated Alcohols: Green Synthesis of Oxygen Heterocycles

Amberlyst-15 (H⁺) resin catalyzes efficient cationic endo-cyclization of γ- and δ-unsaturated alcohols to yield tetrahydro-(2 H)-pyrans and oxepanes. The merits of the present protocol are good yield of the products under mild conditions, simple workup, and reusability of the resin.     

Mononuclear and binuclear iron(III) complexes incorporating N4O3 coordinating heptadentate ligand: Synthesis,structure and magnetic properties

The N₄O₃ coordinating heptadentate ligand afforded the mononuclear [Fe^III(HL)][BPh₄] (1) and binuclear [Fe₂^IIIL(OAc)₂][BPh₄] (2) complexes. In complex 1, the ligand binds in a trianionic N₂O₃ fashion whereas in the case of 2 the ligand binds in the trianionic N₄O₃ form in which the iron ions are held together by μ-phenoxo and bis μ-acetato bridges. In 1, the Fe(III) center has a trigonal bipyramidal geometry (τ = 0.84) whereas in 2 both the Fe(III) centers have a distorted octahedral geometry. Complex 2 shows an intramolecular weak antiferromagnetic interaction. Gas phase geometry optimizations have been performed using density functional theory without any symmetry constraints. The gas phase optimized structures agree well with the X-ray structure.     

Chemical variability in the essential oil of Cinnamomum tamala L. leaves from India

The chemical composition of the essential oils obtained from the fresh leaves of Cinnamomum tamala Nees et Eberm. was determined by GC and GC-MS. The yield of the oil on a dry weight basis ranged from 1.2% to 3.9% (w/w). Phenyl propanoids constitute the major portion (88.9-95.0%) of the oils. Fifty-four compounds were identified from the oils. Eugenol (91.4-41.8%) was the main compound, followed by eugenyl acetate (0.0-47.1%) and α-phellandrene (0.6-2.5%) in the analysed oils.     

Synthesis, characterization, DNA binding and antimicrobial studies on bis(1-amidino-O-2-alkoxyethylurea) copper(II) chloride complexes (alkoxy?=?methoxy or ethoxy)

Copper(II) complexes of [Cu(II)(1-amidino-O-2-methoxyethylurea)₂]Cl₂ (1) and [Cu(II)(1-amidino-O-2-ethoxyethylurea)₂]Cl₂ (2) have been synthesized and characterized by elemental analysis, magnetic moment, conductance, thermal analysis, IR, UV, powdered XRD and EPR spectral studies. The trend in g values g _||?>?g _???>?2.0023 in the EPR spectra of the complexes suggest that the unpaired electron on copper(II) ion has ${d_{x}}^2 - {{}_{y}}^2$ character and the complexes have square planar structure which is also supported by electronic absorption spectral studies. The bonding parameters of these complexes in DMF have been calculated based on the EPR and electronic spectral data. The complexes (1) and (2) exhibit K _||?>?K _?? which indicates the presence of significant out-of-plane ?? bonding. Powdered XRD spectral patterns show that complexes crystallize in a monoclinic system. The binding of the complexes with calf thymus DNA was investigated by absorption and emission spectroscopy, viscosity measurements, DNA melting and cyclic voltammetric studies. DNA interaction studies show that the complexes bind to calf thymus DNA in a non-intercalative mode. The two complexes exhibit growth inhibitory activity against pathogenic bacteria, viz., Escherichia coli, Klebsiella pneumoniae sub sp. Pneumoniae, Proteus mirabilis.     

Pyrrole Based Schiff Bases as Colorimetric and Fluorescent Chemosensors for Fluoride and Hydroxide Anions

An efficient colorimetric sensor with pyrrole-NH moiety as binding site and nitro group as a signaling unit has been synthesized by a one step procedure and characterized by spectroscopic techniques, which displays excellent selectivity and sensitivity for fluoride and hydroxide ions. The hydrogen bonding with these anions provides remarkable colorimetric responses. ¹H NMR and FT IR studies has been carried out to confirm the hydrogen bonding. UV–vis and fluorescence spectral changes can be exploited for real time and on site application.