Synthesis of novel benzo[h][1,6]naphthyridine derivatives from 4-aminoquinoline and cyclic β-ketoester

This paper describes the synthesis of 2,8-dichloroquinolin-4-amine 4 and 4,5,7-trichloro-3-(2-chloroethyl)-2-methylbenzo[h][1,6]naphthyridine 8 as novel class of building blocks. Also describes the regioselective S_NAr reactions of 2,4,8-trichloroquinoline 2 on C₂ and C₄ positions with azide, similarly S_NAr reactions of benzo[h][1,6]naphthyridine 8 at C₄, C₅ positions, and S_N2 reactions on C₃-(2-chloroethyl) side chain with nucleophiles such as primary aromatic amines, methoxide/ethoxide, and azide at different temperatures.     

Total Synthesis of (E/Z) des-Hydroxy Triticone A and B

The first total synthesis of des-hydroxy triticone A and B was achieved in 12 steps. The highly chemoselective, base mediated iodolactamization of olefins with N-OMe amide motif is a key highlight of the synthesis.     

Normal- and reversed-phase high-performance thin-layer chromatography methods for the simultaneous determination of remogliflozin etabonate and metformin hydrochloride antidiabetic drugs in bulk and tablet formulation

JPC – Journal of Planar Chromatography – Modern TLC - Two new, simple, fast, and sensitive methods, normal- and reversed-phase high-performance thin-layer chromatography (NP-HPTLC and...     

Revision of the Absolute Configurations of Chelocardin and Amidochelocardin

Even with the aid of the available methods, the configurational assignment of natural products can be a challenging task that is prone to errors, and it sometimes needs to be corrected after total synthesis or single-crystal X-ray diffraction (XRD) analysis. Herein, the absolute configuration of amidochelocardin is revised using a combination of XRD, NMR spectroscopy, experimental ECD spectra, and time-dependent density-functional theory (TDDFT)-ECD calculations. As amidochelocardin was obtained via biosynthetic engineering of chelocardin, we propose the same absolute configuration for chelocardin based on the similar biosynthetic origins of the two compounds and result of TDDFT-ECD calculations. The evaluation of spectral data of two closely related analogues, 6-desmethyl-chelocardin and its semisynthetic derivative 1 , also supports this conclusion.     

ChemInform Abstract: Theoretical Study of Structural and Vibrational Properties of Al3N3, Ga3N3, and In3N3.

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