On the Convolution of a Finite Number of Analytic Functions Involving a Generalized Srivastava–Attiya Operator

The present paper gives several subordination results involving a generalized Srivastava–Attiya operator (defined below). Among the results presented in this paper include also a sufficiency condition for the convexity of the convolution of certain functions and a sharp result relating to the convolution structure. We also mention various useful special cases of the main results including those which are related to the Zeta function.     

Synthetic strategies for 1,4,5/4,5-substituted azoles: A perspective review

Azole nucleus represents an important class of biologically active compounds that are gaining more attention in the field of medicinal chemistry due to large number of structure diversity. Among azoles, pyrazoles, and isoxazoles five-membered nitrogen containing heterocyclic compounds are associated wide range of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, etc. Some of azole derivatives (e.g., 1,4,5-trisubstituted pyrazoles, 4,5-disubstituted isoxazoles, and 4,5-disubstituted-1H-pyrazoles) are still unexplored in literature, these unexplored azoles have fascinated the consideration of many researchers to study their framework synthetically and biologically. This present review is an attempt to update and understand the chemistry of unexplored pyrazoles and isoxazoles along with their medicinal importance. This article would definitely help the researchers to bring further enhancement in the synthesis of biologically active pyrazoles and isoxazoles.     

Synthesis of new macrocyclic rhodium(III) compounds and their utility as catalysts for the oxidation of ascorbic acid

Ten new macrocyclic Schiff base Rh(III) compounds were synthesized by treating the corresponding macrocycles with rhodium chloride in 1:1 ratio. The resulting compounds were characterized by elemental, IR, ¹H NMR, ¹³C NMR, mass, electronic spectral analysis, and their structures have been proposed. These compounds were utilized as catalysts in the development of an efficient and environmentally friendly catalytic method for the oxidation of ascorbic acid (AA) to dehydroascorbic acid (DHAA). DHAA was determined spectrophotometrically by treating with orthophenylenediamine (OPDA) and the yields were found to be in the range 72–84%. The catalytic oxidation and spectrophotometric determination methods were found to be faster and more accurate than those reported previously.     

Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells

Mouse natural killer T (NKT) cells expressing an invariant T cell antigen receptor (TCR) recognize glycosphingolipids (GSLs) from Sphingomonas bacteria. The synthetic antigens previously tested, however, were designed to closely resemble the potent synthetic agonist alpha-galactosyl ceramide (alphaGalCer), which contains a monosaccharide and a C18:0 sphingosine lipid. Some Sphingomonas bacteria, however, also have oligosaccharide-containing GSLs, and they normally synthesize several GSLs with different sphingosine chains including one with a cyclopropyl ring-containing C21:0 (C21cycl) sphingosine. Here we studied the stimulation of NKT cells with synthetic GSL antigens containing natural tetrasaccharide sugars, or the C21cycl sphingosine. Our results indicate that there is a great degree of variability in the antigenic potency of different natural Sphingomonas glycolipids, with the C21cycl sphingosine having intermediate potency and the oligosaccharide-containing antigens exhibiting limited or no stimulatory capacity.     

Adsorption of molecular hydrogen on inorganometallic complexes B<Subscript>2</Subscript>H<Subscript>4</Subscript>M (M=Li,Be, Sc,Ti, V)

Molecular interaction between hydrogen molecules and B₂H₄M (M=Li, Be, Sc, Ti, V) complexes has been studied using the DFT method (M06 functional) and 6-311++G** basis set. The hydrogen uptake capacity of the complexes considered is higher than the target set by the US Department of Energy (5.5 wt% by 2020). The metal atom bound strongly to the B₂H₄ substrate. Adsorption of molecular hydrogen on Be-, Ti-, and V-decorated complexes is thermodynamically possible for all the pressures and temperatures considered whereas it is unfavorable for Li-decorated complexes for all the pressure and temperatures. For the Sc-doped complexes, adsorption of molecular hydrogen is favorable below 330 K and entire pressure range considered. All the H₂ adsorbed complexes are kinetically stable. For all the complexes, the interaction between the inorganometallic complexes and the H₂ molecules adsorbed is attractive whereas that between adsorbed H₂ molecules is repulsive. We have also performed molecular dynamics simulations to confirm the same number of H₂ molecule adsorption from the simulations and DFT calculations.     

Water dispersed gold nanoparticles catalyzed aerobic oxidative cross-dehydrogenative coupling: An efficient synthesis of α-ketoamides in water

An effective green synthesis of α-ketoamides was developed for the first time in water via gold nanoparticles (AuNPs) catalyzed aerobic oxidative cross-dehydrogenative coupling of secondary amines with phenylglyoxals with a broad substrate scope.     

Synthesis of 2,4- and 2,4,5-substituted oxazoles via a silver triflate mediated cyclization

2,4- and 2,4,5-substituted oxazoles were prepared from a broad range of bromo-ketones and amides in high yield and purity.     

Simple, facile and one-pot conversion of the Baylis-Hillman acetates into 3,5,6-trisubstituted-2-pyridones

A facile route for the synthesis of novel 3,5,6-trisubstituted-2-pyridones from the acetylated Baylis-Hillman esters with β-enamino esters or β-enamino nitriles in one pot with good yields is described.     

Cubic Auto-Catalysis Reactions in Three-Dimensional Nanofluid Flow Considering Viscous and Joule Dissipations Under Thermal Jump

In this problem, simultaneous effects of Joule and viscous dissipationin three-dimensional flow of nanoliquid have been addressed in slip flow regime under timedependent rotational oscillations. Silver nanoparticles are submerged in the base fluid (water)due to their chemical and biological features. To increment the novelty, effects of cubicautocatalysis chemical reactions and radiative heat transfer have been incorporated in therelated boundary layer equations. Dimensionless partial differential system is solved byemploying the proposed implicit finite difference approach. Convergence conditions andstability criteria are obtained to ensure the convergence and accuracy of solutions.A comparative analysis is proposed for no-slip nanofluid flow (NSNF) and slip nanofluid flow(SNF). Variations in skin-friction coefficients, Sherwood and Nusselt numbers against physicalparameters are tabulated. It is investigated that velocity slip and temperature jump significantlycontrol drag forces and rate of heat transfer.     

A rapid and highly sensitive UPLC-MS-MS method for the quantification of zolpidem tartrate in human EDTA plasma and its application to pharmacokinetic study

A rapid and high sensitive liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed and validated for the quantification of zolpidem in human EDTA plasma using ondansetron (IS) as an internal standard. The analyte and IS were extracted from human plasma using ethyl acetate and separated on a C18 column (Inertsil-ODS, 5 μm, 4.6 × 50 mm) interfaced with a triple quadrupole tandem mass spectrometer. The mobile phase, which consisted of a mixture of methanol and 20 mM ammonium formate (pH 5.00 ± 0.05; 75:25 v/v), was injected at a flow rate of 0.40 mL/min. The retention times of zolpidem and IS were approximately 1.76 and 1.22. The LC run time was 3 min. The electrospray ionization source was operated in positive ion mode. Multiple reaction monitoring used the [M + H](+) ions m/z 308.13 → 235.21 for zolpidem and m/z 294.02 → 170.09 for the ondansetron, respectively. Five freeze-thaw cycles was established at -20 and -70°C.The linearity of the response/concentration curve was established in human EDTA plasma over the concentration range 0.10-149.83 ng/mL. The lower detection limit [(signal-to-noise (S/N) > 3] was 0.04 ng/mL and the lower limit of quantification (S/N > 10) was 0.10 ng/mL. This LC-MS-MS method was validated with intra-batch and inter-batch precision of 0.52-8.66.The intra-batch and inter-batch accuracy was 96.66-106.11. Recovery of zolpidem in human plasma was 87.00% and IS recovery was 81.60%. The primary pharmacokinetic parameters were T(max) (h) = (1.25 ± 0.725), C(max) (ng/mL) (127.80 ± 34.081), AUC(0→t), = (665.37 ± 320.982) and AUC(0→∞), 686.03 ± 342.952, respectively.