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991.
Helen A. Goulart Daniela R. Araujo Filipe Penteado Raquel G. Jacob Gelson Perin Eder J. Lenardo 《Molecules (Basel, Switzerland)》2021,26(24)
Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO5) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has become a powerful tool in organic synthesis, being extensively employed to mediate the construction of a plethora of important compounds. This review summarizes the recent advances in the Oxone-mediated synthesis of N-, O- and chalcogen-containing heterocyclic compounds, through a wide diversity of reactions, starting from several kinds of substrate, highlighting the main synthetic differences, advantages, the scope and limitations. 相似文献
992.
Roberto-F. De Souza Raquel S. Mauler Leonardo C. Simon Fernanda F. Nunes Daniela V. S. Vescia Alessandro Cavagnolli 《Macromolecular rapid communications》1997,18(9):795-800
The complex [η3-methallyl-nickel-dad]PF6 is a new catalyst precursor for ethylene polymerization. The system is active in the presence of usual organoaluminium compounds like diethylaluminium chloride, at low Al/Ni ratios and under mild reaction conditions (temperatures between −10°C and 25°C, ethylene partial pressure from 1 to 15 atm). The polymers show extensive methyl branching, whose content is controlled by reaction parameters like temperature and ethylene pressure. 相似文献
993.
Silvio Aime Alessandro Barge Mauro Botta Alvaro S. De Sousa David Parker 《Angewandte Chemie (International ed. in English)》1998,37(19):2673-2675
A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III ) complex with an octadentate, neutral macrocyclic ligand (kex( M )<kex( m )). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging. 相似文献
994.
Renato B. Pereira Nuno F. S. Pinto Maria Jos G. Fernandes Tatiana F. Vieira Ana Rita O. Rodrigues David M. Pereira Srgio F. Sousa Elisabete M. S. Castanheira A. Gil Fortes M. Sameiro T. Gonalves 《Molecules (Basel, Switzerland)》2021,26(21)
A series of β-amino alcohols were prepared by the reaction of eugenol epoxide with aliphatic and aromatic amine nucleophiles. The synthesized compounds were fully characterized and evaluated as potential insecticides through the assessment of their biological activity against Sf9 insect cells, compared with a commercial synthetic pesticide (chlorpyrifos, CHPY). Three derivatives bearing a terminal benzene ring, either substituted or unsubstituted, were identified as the most potent molecules, two of them displaying higher toxicity to insect cells than CHPY. In addition, the most promising molecules were able to increase the activity of serine proteases (caspases) pivotal to apoptosis and were more toxic to insect cells than human cells. Structure-based inverted virtual screening and molecular dynamics simulations demonstrate that these molecules likely target acetylcholinesterase and/or the insect odorant-binding proteins and are able to form stable complexes with these proteins. Encapsulation assays in liposomes of DMPG and DPPC/DMPG (1:1) were performed for the most active compound, and high encapsulation efficiencies were obtained. A thermosensitive formulation was achieved with the compound release being more efficient at higher temperatures. 相似文献
995.
Patricia Reboredo-Rodríguez Carmen Gonzlez-Barreiro Elena Martínez-Carballo Noelia Cambeiro-Prez Raquel Rial-Otero María Figueiredo-Gonzlez Beatriz Cancho-Grande 《Molecules (Basel, Switzerland)》2021,26(21)
The Mediterranean diet includes virgin olive oil (VOO) as the main fat and olives as snacks. In addition to providing nutritional and organoleptic properties, VOO and the fruits (olives) contain an extensive number of bioactive compounds, mainly phenolic compounds, which are considered to be powerful antioxidants. Furthermore, olive byproducts, such as olive leaves, olive pomace, and olive mill wastewater, considered also as rich sources of phenolic compounds, are now valorized due to being mainly applied in the pharmaceutical and nutraceutical industries. The digestive system must physically and chemically break down these ingested olive-related products to release their phenolic compounds, which will be further metabolized to be used by the human organism. The first purpose of this review is to provide an overview of the current status of in-vitro static digestion models for olive-related products. In this sense, the in-vitro gastrointestinal digestion methods are widely used with the following aims: (i) to study how phenolic compounds are released from their matrices and to identify structural changes of phenolic compounds after the digestion of olive fruits and oils and (ii) to support the functional value of olive leaves and byproducts generated in the olive industry by assessing their health properties before and after the gastrointestinal process. The second purpose of this review is to survey and discuss all the results available to date. 相似文献
996.
Luiz Jardelino de Lacerda Neto Andreza Guedes Barbosa Ramos Thiago Sampaio de Freitas Cristina Rodrigues dos Santos Barbosa Drcio Luiz de Sousa Júnior Abolghasem Siyadatpanah Morteza Nejat Polrat Wilairatana Henrique Douglas Melo Coutinho Francisco Assis Bezerra da Cunha 《Molecules (Basel, Switzerland)》2021,26(18)
Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial activity against Staphylococcus aureus and toxic action against Drosophila melanogaster; we aimed to verify these activities. The broth microdilution tests determined the minimum inhibitory concentration (MIC) of benzaldehyde alone and in association with antibiotics and ethidium bromide (EtBr). Toxicity against Drosophila melanogaster was determined by fumigation tests that measured lethality and damage to the locomotor system. The results indicated that there was an association of norfloxacin and ciprofloxacin with benzaldehyde, from 64 μg/mL to 32 μg/mL of ciprofloxacin in the strain K6028 and from 256 μg/mL to 128 μg/mL of norfloxacin in the strain 1199B; however, the associations were not able to interfere with the functioning of the tested efflux pumps. In addition, benzaldehyde had a toxic effect on flies. Thus, the results proved the ability of benzaldehyde to modulate quinolone antibiotics and its toxic effects on fruit flies, thus enabling further studies in this area. 相似文献
997.
Inmaculada Yruela Raquel Tom s Miguel Alfonso Rafael Picorel 《Journal of photochemistry and photobiology. B, Biology》1999,50(2-3):129-136
The effect of pH on the Qy absorption band has been studied in the isolated D1-D2-cytochrome b559 complex. The pH treatments are done on an ion-exchange chromatographic column. The absorption spectra at 77 K of the complex treated with acidic pH show irreversible loss of absorbance at both the blue and the red sides of the Qy absorption band, with minima at 664.5 and 683.5 nm, respectively. These absorption changes are not accompanied by modifications in the Qx absorption region characteristic of pheophytin pigments. Furthermore, the pigment composition of the D1-D2-cytochrome b559 complex remains unchanged after this treatment. The effects of basic pH are similar to those of acidic pH, but somewhat more pronounced. These results suggest that chlorophyll pigments absorbing at 664.5 and 683.5 nm are located on or close to the surface of the complex. Freezing/thawing cycle treatment first affects the band absorbing at 683.6 nm, indicating that it corresponds to the chlorophyll most exposed to the medium in the D1-D2-cytochrome b559 complex. At pH <5 a small reversible change at 672.5 nm is measured that correlates with a reversible change at 542 nm, indicating that inactive pheophytin a will absorb at this wavelength. 相似文献
998.
E.M. de Sousa Luz A.F. Siqueira U.M.S. Costa M.L. Lyra 《The European Physical Journal B - Condensed Matter and Complex Systems》1999,12(1):115-118
The recent improvements on the technology for developing high-quality thin magnetic films has renewed the interest in the
study of surface effects in both static and dynamic magnetic responses. In this work, we use a Monte-Carlo algorithm with
Metropolis dynamics together with a spreading of damage technique to study the interplay between the effects of finite thickness
and surface ordering field in thin ferromagnetic Ising (S=1/2) films. We calculate, near the bulk critical temperature and several values of the surface field, the dependence on the
film thickness of the average magnetization M and Hamming distance D. We employ a finite size scaling analysis to show that both obey an effective one-parameter scaling but exhibit distinct
characteristic surface fields. At their corresponding characteristic surface fields both M and D become roughly thickness independent and we estimate the critical exponent characterizing the behavior of the typical scaling
lengths.
Received 29 March 1999 and Received in final form 21 April 1999 相似文献
999.
Raquel A. Fernandes Maria J. Sampaio Joaquim L. Faria Cludia G. Silva 《Molecules (Basel, Switzerland)》2022,27(4)
Vitamin B3 (nicotinic acid, VB3) was synthesized through the photocatalytic oxidation of 3-pyridinemethanol (3PM) under visible-light-emitting diode (LED) irradiation using metal-free graphitic carbon nitride (GCN) - based materials. A bulk (GCN) material was prepared by a simple thermal treatment using dicyandiamide as the precursor. A post-thermal treatment under static air and nitrogen flow was employed to obtain the GCN-T and GCN-T-N materials, respectively. The conditions adopted during the post-treatment revealed differences in the resulting materials’ morphological, electronic, and optical properties. The post-treated photocatalysts revealed an enhanced efficiency in the oxidation of 3PM into VB3, with the GCN-T-N photocatalyst being the best-performing material. The defective surface, reduced crystallinity, and superior photoabsorption of GCN-T-N account for this material’s improved performance in the production of VB3. Nevertheless, the presence of nitrogen vacancies in the carbon nitride structure and, consequently, the creation of mid-gap states also accounts to its highly oxidative ability. The immobilization of GCN-T-N in sodium alginate hydrogel was revealed as a promising strategy to produce VB3, avoiding the need for the photocatalyst separation step. Concerning the mechanism of synthesis of VB3 through the photocatalytic oxidation of 3PM, it was possible to identify the presence of 3-pyridinecarboxaldehyde (3PC) as the intermediary product. 相似文献
1000.
GonÇalves Luciana R. B. Fernandez-Lafuente Roberto Guisán Jose M. Giordano Raquel L. C. 《Applied biochemistry and biotechnology》2000,84(1-9):931-945
We presenta kinetic model for the synthesis of amoxicillin from p-hydroxyphenylglycine methyl ester and 6-aminopenicillanic acid, catalyzed by penicillin G acylase immobilized on agarose,
at 25°C. Michaelis-Menten kinetic parameters (with and without inhibition) were obtained from initial velocity data (pH 7.5
and 6.5). Amoxicillin synthesis reactions were used to validate the kinetic model after checking mass transport effects. A
reasonable representation of this system was achieved under some operational conditions, but the model failed under others.
Nevertheless, it will be useful whenever a simplified model is required, e.g., in model-based control algorithms for the enzymatic
reactor. 相似文献