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141.
Labruère R Helissey P Desbène-Finck S Giorgi-Renault S 《The Journal of organic chemistry》2008,73(9):3642-3645
The first N1-alkyl-4-amino-1,2-dihydroquinoline-lactone has been prepared by a five-step sequence in a 51% overall yield via the corresponding furo[3,4-b]quinolin-1(3H)-one. A new practical synthesis of this intermediate was carried out using versatile, commercially available starting materials and constitutes the shortest and highest yielding route. These synthetic pathways could be widened with a view toward the preparation of different substituted derivatives, which could be considered as rigid aminologues of 4-aza-2,3-didehydropodophyllotoxins. 相似文献
142.
Breton F Delépée R Jégourel D Deville-Bonne D Agrofoglio LA 《Analytica chimica acta》2008,616(2):222-229
Molecularly imprinted polymers (MIPs) were prepared for adenosine-5′-monophosphate (AMP), a substrate of AMP-activated protein kinase. The template molecule was formed by the vinylphenylboronate diester of adenosine on which 5′-free hydroxide was protected by tert-butyldimethylsilyl group in order to mimic the steric hindrance of the phosphate moiety of AMP. Molecular imprinting was performed by complexing acrylamide and the template in a highly cross-linked polymer. MIPs were tested in batch experiments with aqueous samples of nucleotides and a number of parameters were investigated. The use of tetrabutylammonium hydroxide (TBAH) was necessary to obtain a rebinding of nucleotides on MIP. The adsorption of AMP was optimal in 5 mM ammonium acetate buffer solution pH 9.5 for 30 min, with 30 mM of TBAH. The imprinted polymer was selective for AMP towards others nucleotides or deoxi analogues. 相似文献
143.
The compound Ba4Fe2I5S4 has been prepared at 1223-1123 K by the "U-assisted" reaction of FeS, BaS, S, and U with BaI2 as a flux. A more rational synthesis was also found; however, the presence of U appears to be essential for the formation of single crystals suitable for X-ray diffraction studies. Ba4Fe2I5S4 crystallizes in a new structure type with two formula units in space group I4/m of the tetragonal system. The structure consists of a Ba-I network penetrated by (1)infinity[Fe2S4] chains. Each Fe atom, which is located on a site with 4 symmetry, is tetrahedrally coordinated to four S atoms. The FeS4 tetrahedra edge-share to form linear (1)infinity[Fe2S4] chains in the [001] direction. The Fe-Fe interatomic distance in these chains is 2.5630(4) A, only about 3% longer than the shortest Fe-Fe distance in -Fe metal. Charge balance dictates that the average formal oxidation state of Fe in these chains is +2.5. The M?ssbauer spectra obtained at 85 and 270 K comprise a single quadrupole doublet that has hyperfine parameters consistent with an average Fe oxidation state of +2.5. The M?ssbauer spectrum obtained at 4.2 K consists of a single magnetic sextet with a small hyperfine field of -15.5 T. This spectrum is also consistent with rapid electron delocalization and an average Fe oxidation state of +2.5. The molar magnetic susceptibility of Ba4Fe2I5S4, obtained between 3.4 and 300 K, qualitatively indicates the presence of weak pseudo-one-dimensional ferromagnetic exchange within a linear chain above 100 K and weak three-dimensional ordering between the chains at lower temperatures. 相似文献
144.
Schaeffer N Tan B Dickinson C Rosseinsky MJ Laromaine A McComb DW Stevens MM Wang Y Petit L Barentin C Spiller DG Cooper AI Lévy R 《Chemical communications (Cambridge, England)》2008,(34):3986-3988
The synthesis of fluorescent water-soluble gold nanoparticles by the reduction of a gold salt in the presence of a designed polymer ligand is described, the size and fluorescence of the particles being controlled by the polymer to gold ratio; the most fluorescent nanomaterial has a 3% quantum yield, a 1.1 nm gold core and a 6.9 nm hydrodynamic radius. 相似文献
145.
Towards a General Understanding of Carbonyl‐Stabilised Ammonium Ylide‐Mediated Epoxidation Reactions
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Prof. Raphaël Robiette Prof. Mario Waser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(32):11422-11428
The key factors for carbonyl‐stabilised ammonium ylide‐mediated epoxidation reactions were systematically investigated by experimental and computational means and the hereby obtained energy profiles provide explanations for the observed experimental results. In addition, we were able to identify the first tertiary amine‐based chiral auxiliary that allows for high enantioselectivities and high yields for such epoxidation reactions. 相似文献
146.
Raphaël Gauthier Nikolaos V. Tzouras Ziyun Zhang Sandrine Bédard Marina Saab Dr. Laura Falivene Prof. Dr. Kristof Van Hecke Prof. Dr. Luigi Cavallo Prof. Dr. Steven P. Nolan Prof. Jean-François Paquin 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(4):e202103886
An efficient and chemoselective methodology deploying gold-N-heterocyclic carbene (NHC) complexes as catalysts in the hydrofluorination of terminal alkynes using aqueous HF has been developed. Mechanistic studies shed light on an in situ generated catalyst, formed by the reaction of Brønsted basic gold pre-catalysts with HF in water, which exhibits the highest reactivity and chemoselectivity. The catalytic system has a wide alkyl substituted-substrate scope, and stoichiometric as well as catalytic reactions with tailor-designed gold pre-catalysts enable the identification of various gold species involved along the catalytic cycle. Computational studies aid in understanding the chemoselectivity observed through examination of key mechanistic steps for phosphine- and NHC-coordinated gold species bearing the triflate counterion and the elusive key complex bearing a bifluoride counterion. 相似文献
147.
Zareath Pamela Terán Baptista Analía de los Angeles Gómez Raphaël Grougnet Tsvetelina Mandova Pedro Adrían Aredes Fernandez 《Natural product research》2020,34(12):1782-1785
AbstractExtracts from aerial parts of medicinal plants from northwest Argentina were screened for antibacterial activity against the phytopathogenic strains namely CECT 124 (Pseudomonas corrugata), CECT 126 (P. syringae pv. tomato), CECT 225 (Erwinia carotovora var. carotovora), CECT 472 (Agrobacterium tumefaciens) and CECT 792 (Xanthomonas campestres pv. vesicatoria). Leaves and stems of Aspidosperma quebracho-blanco, Schinus fasciculatus, S. gracilipes, Amphilophium cynanchoides and Tecoma stans were separately extracted with solvents of increasing polarity to obtain the dichloromethane (fCH2Cl2), ethyl acetate (fEtAc) and methanol extracts (fMeOH), respectively. Among the thirty extracts tested, only fEtAc from leaves and stems of S. fasciculatus reached the IC50 against the five bacterial strains tested (IC50?=?0.9?mg/ml). The fEtAc from the leaves contained kaempferol, quercetin and agathisflavone which had moderate to strong antibacterial activity. This extract and its identified flavonoids showed synergic (CECT 124,126 and 792) or additive effects (CECT 472 and 225) in mixtures with Kocide 3000. 相似文献
148.
Two-dimensional database of a Burkitt lymphoma cell line (DG 75) proteins: protein pattern changes following treatment with 5'-azycytidine. 总被引:5,自引:0,他引:5
F Poirier M Pontet V Labas J P le Ca?r N Sghiouar-Imam M Rapha?l M Caron R Joubert-Caron 《Electrophoresis》2001,22(9):1867-1877
Hypermethylation is an important mechanism for repression of tumor gene suppressor in cancer. The drug 5'-azacytidine (AZC) has been used as demethylating agent to induce the expression of previously silencing genes. In the present work, we attempted to determine, using proteomics, the changes in protein expression profiles following a treatment of an Epstein Barr virus (EBV)-negative Burkitt lymphoma (BL) cell line DG 75. The effects of the treatment in terms of cell viability and growth were first examined. The following observations were made: AZC treatment led to (i) a decrease in cell growth with an arrest of the cell at G0/G1 phase of the cell cycle, (ii) the expression of p16, a tumor-suppressor gene whose expression was dependent on its promoter demethylation. Proteomic study evidenced that AZC treatment affected protein expression in two different ways. Twenty-one polypeptides were down-expressed, while 14 showed an increased expression. Some of the upregulated proteins appeared related to the energy metabolism, to organization of cytoskeletal structures, and to cell viability and protein synthesis. We also established a reference map for proteins in DG 75 cell line, comprising 74 different polypeptides corresponding to 67 proteins. This map will be accessible via Internet as a resource for proteome analyses of B-cells. Taken together, the results presented here highlight new insights into lymphoma cell gene regulations following a treatment of lymphoma cells with AZC and illustrate a use of proteomics to evidence the direct and indirect effects of a drug and the pathways it possibly regulates. 相似文献
149.
Philippe Lecomte Raphaël Riva Stéphanie Schmeits Jutta Rieger Kathy Van Butsele Christine Jérôme Robert Jérôme 《Macromolecular Symposia》2006,240(1):157-165
Recent progress in the synthesis of aliphatic polyesters, substituted by pendent functional groups, has been reviewed. Two main strategies have to be distinguished. The first route consists of the ring-opening polymerization of ε-caprolactone substituted by various functional groups, protected if needed, in α- or γ-position. In a second strategy, the functional groups are grafted onto preformed polyesters chains in α-position of the carbonyl groups. α-chloro-ε-caprolactone is quite an interesting monomer because, after polymerization, the activated chloride can be easily derivatized by atom transfer radical addition and “click” chemistry, respectively. Similarly, γ-acrylic-ε-caprolactone is precursor of (co)polyesters well-suited to derivatization of the pendent double bonds by Michael addition. 相似文献
150.
Raphaël Riva Wenda Lazzari Leen Billiet Filip Du Prez Christine Jérôme Philippe Lecomte 《Journal of polymer science. Part A, Polymer chemistry》2011,49(7):1552-1563
This article reports on the synthesis of a new pH‐sensitive amphiphilic A2B mikto‐arm star‐shaped aliphatic copolyester [with A = poly(ε‐caprolactone) and B = tertiary amine‐bearing poly(ε‐caprolactone)] with two hydrophobic arms and one hydrophilic arm when protonated at pH = 5.5. First, the ring‐opening polymerization of ε‐caprolactone (εCL) was initiated by an aliphatic diol substituted by an alkyne. The copper(I) catalyzed azide‐alkyne cycloaddition (CuAAC) was use to convert the alkyne into a hydroxyl group prone to initiate the ring‐opening copolymerization of γ‐bromo‐ε‐caprolactone (γBrεCL) and εCL. After the substitution of the bromide atoms into azide functions, the N,N‐dimethylprop‐2‐yn‐1‐amine was grafted onto the azide bearing PCL arm by CuAAC, with the purpose to make the B arm hydrophilic at low pH. The precursors of the A2B copolymers were characterized by 1H NMR, SEC, and MALDI‐TOF. As expected, the A2B copolyester was soluble into water at pH = 5. The formation of polymersomes in water at pH 5 was assessed by DLS and TEM analyses. The effects of the architecture and the molecular weight of the A2B copolymers on the formation of polymersomes were investigated. Moreover, the versatility of our approach was demonstrated by the synthesis of an AB2 star‐shaped copolyester. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 相似文献