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Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring-opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly((RS)-3,3-dimethylmalic acid) and hydrophobic poly(hexyl (RS)-3,3-dimethylmalate) segments. Micelles obtained from a well-defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM). 相似文献
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Aaron Solo 《BIT Numerical Mathematics》2008,48(1):117-137
Consider a homogeneous parabolic problem on a smooth bounded domain in ℝ
N
but with initial data and Neumann boundary data of low regularity. Sharp interior maximum norm error estimates are given
for a semidiscrete C
0 finite element approximation to this problem. These estimates are obtained by first establishing a new localized L
∞ estimate for semidiscrete finite element approximations on interior subdomains. Numerical examples illustrate the findings.
AMS subject classification (2000) 65N30 相似文献
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Aaron Solo. 《Mathematics of Computation》2007,76(260):1787-1800
Consider a second order homogeneous elliptic problem with smooth coefficients, , on a smooth domain, , but with Neumann boundary data of low regularity. Interior maximum norm error estimates are given for finite element approximations to this problem. When the Neumann data is not in , these local estimates are not of optimal order but are nevertheless shown to be sharp. A method for ameliorating this sub-optimality by preliminary smoothing of the boundary data is given. Numerical examples illustrate the findings.