全文获取类型
收费全文 | 264篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
化学 | 156篇 |
晶体学 | 5篇 |
力学 | 7篇 |
数学 | 20篇 |
物理学 | 86篇 |
出版年
2024年 | 3篇 |
2023年 | 4篇 |
2022年 | 16篇 |
2021年 | 18篇 |
2020年 | 19篇 |
2019年 | 17篇 |
2018年 | 16篇 |
2017年 | 13篇 |
2016年 | 23篇 |
2015年 | 10篇 |
2014年 | 8篇 |
2013年 | 17篇 |
2012年 | 21篇 |
2011年 | 17篇 |
2010年 | 9篇 |
2009年 | 9篇 |
2008年 | 3篇 |
2007年 | 4篇 |
2006年 | 7篇 |
2005年 | 9篇 |
2004年 | 4篇 |
2003年 | 3篇 |
2002年 | 4篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有274条查询结果,搜索用时 640 毫秒
121.
Gupta AK Palit M Dubey DK Raza SK 《European journal of mass spectrometry (Chichester, England)》2005,11(1):119-125
A series of organophosphorus compounds related to PB-1 toxin [O,O-diphenyl N- cyclooctylphosphoramidate] occurring in dinoflagellate algae as fish toxin have been synthesized and subjected to mass spectral studies under electron ionization. The fragmentation pattern obtained for the compounds has been substantiated by performing tandem mass spectrometry experiments in product ion scan mode. 相似文献
122.
Synthesis,spectroscopic characterization,and computed optical analysis of green fluorescent cyclohexenone derivatives 下载免费PDF全文
Muhammad Faizan Nazar Amir Badshah Asif Mahmood Muhammad Naveed Zafar Muhammad Ramzan Saeed Ashraf Janjua Muhammad Asam Raza Riaz Hussain 《Journal of Physical Organic Chemistry》2016,29(3):152-160
Cyclohexenone containing chalcones core is one important class of materials, which exhibit high nonlinear optical (NLO) responses and good crystallizability. The present study reports the successful development of six new fluorescent cyclohexenone derivatives (CDs) via conventional Robinson annulation method. The molecular structures of these newly synthesized CDs were confirmed by using various analytical techniques such as 1H NMR, 13C NMR, FTIR, EIMS, UV–Vis spectroscopy and single crystal X‐ray diffraction. The crystallographic data revealed that the spatial structure of the representative CD (4BE) belongs to monoclinic, P21/c space group. The results from luminescence studies show that the CDs molecules apparently emit intense green light at room temperature in aqueous media. The relative polarity and molecular chemical stability of the CDs molecules were predicted by measuring the molecular electrostatic potential and frontier molecular orbital energy. In addition, the UV–Vis spectra, transition character and electronic structures of these CDs were computed by using quantum chemical methodology. It was interesting to note that the values of computed and experimental electronic transitions (λmax) were in good agreement and these CDs display high hyperpolarizability (β) values. The present work will be helpful for systematical understanding of the structures and the optical properties of CDs for studying the structure–activity relationship that will suggest their potential application in photonic devices. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
123.
Abdur Rauf Ghias Uddin Muslim Raza Muhammad Zafar Harukuni Tokuda 《Natural product research》2016,30(10):1205-1207
In this study, the anti-tumour-promoting and thermal-induced protein denaturation inhibitory activities of β-sitosterol (1) and lupeol (2), isolated from Diospyros lotus L., were explored. Compound 1 showed a marked concentration-dependent inhibition against 12-O-tetradecanoylphorbol-13-acetate (20 ng/32 pmol)-induced Epstein–Barr virus early antigen activation in Raji cells with IC50 of 270 μg/ml, without significant toxicity (70% viability). Compound 2 showed significant anti-tumour-promoting effect with IC50 of 412 μg/ml, without significant toxicity (60% viability). In heat-induced protein denaturation assay, compound 1 exhibited a concentration-dependent attenuation with a maximum effect of 73.5% at 500 μg/ml with EC50 of 117 μg/ml, while compound 2 exhibited a maximum effect of 59.2% at 500 μg/ml with EC50 of 355 μg/ml. Moreover, in silico docking studies against the phosphoinositide 3-kinase enzyme also show the inhibitory potency of these compounds. In short, both the compounds exhibited a marked anti-tumour-promoting and potent inhibitory effect on thermal-induced protein denaturation. 相似文献
124.
Lantanilic acid, camaric acid and oleanolic acid possessing nematicidal activity were isolated from the methanolic extract of the aerial parts of Lantana camara Linn. through bio-assay guided fractionation. These compounds exhibited 98%, 95% and 70% mortality respectively against root-knot nematode Meloidogyne incognita at 0.5% concentration. Conventional nematicide furadan showed 100% mortality at this concentration. 相似文献
125.
Rameez Ali Sangram S. Parelkar Paul R. Thompson Susan Mitroka-Batsford Siddartha Yerramilli Suzanne F. Scarlata Katelyn S. Mistretta Jeannine M. Coburn Anita E. Mattson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(70):e202202397
Phomoxanthone A is a naturally occurring molecule and a powerful anti-cancer agent, although its mechanism of action is unknown. To facilitate the determination of its biological target(s), we used affinity-based labelling using a phomoxanthone A probe. Labelled proteins were pulled down, subjected to chemoproteomics analysis using LC-MS/MS and ATP synthase was identified as a likely target. Mitochondrial ATP synthase was validated in cultured cells lysates and in live intact cells. Our studies show sixty percent inhibition of ATP synthase by 260 μM phomoxanthone A. 相似文献
126.
127.
Regioselective iodination of phenol and analogues using N-iodosuccinimide and p-toluenesulfonic acid
Mild and highly regioselective monoiodination of phenol and analogues is achieved in high to excellent yields at room temperature with a combination of stoichiometric p-toluenesulfonic acid and N-iodosuccinimide. 相似文献
128.
A. K. Gupta M. Palit D. K. Dubey S. K. Raza 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):1631-1637
A series of phosphonothiolates, including the highly toxic O-Ethyl-S-(2-diisopropylamino) ethyl methylphosphonothioate (VX), have been subjected to chemical neutralization reaction with metallic sodium. The phosphonothiolates decompose to their respective phosphonic and phosphonothioic acids and this results in the detoxification of VX. GC/MS technique in both EI and CI mode has been applied for reaction monitoring and final identification of the neutralization products formed in this reaction. 相似文献
129.
Raza?Murad?GhalibEmail author Rokiah?Hashim P.?S.?Pereira?Silva Othman?Sulaiman 《Journal of chemical crystallography》2011,41(12):1889-1893
Abstract
5-Phenylamino-3-phenylimino-3H[1, 2]dithiole-4-carboxylic acid ethyl ester, C18H16N2O2S2, (I), has been synthesized and the structure has been solved by X–ray diffraction. The crystals are triclinic, space group P[`1] P\bar{1} , with a = 5.7127(2) ?, b = 12.1757(5) ?, c = 14.0734(5) ?, α = 112.1217(16)°, β = 97.786(2)°, γ = 100.694(2)°, Mr = 356.45, V = 868.11(6) ?3, Z = 2 and R = 0.0373. In the title compound there is an intramolecular N–H···O hydrogen bond. The crystal structure is stabilized only by weak C–H···π and π···π interactions as well as by van der Waals forces. The geometry of the isolated molecule was optimized by ab initio quantum mechanical calculations, employing both molecular orbital Hartree-Fock (HF) and density functional theory (DFT) methods. In the DFT calculation the minimum energy was achieved for a conformation very similar to that of the solid-state molecule. 相似文献130.
MA Raza ES Kooij A van Silfhout HJ Zandvliet B Poelsema 《Journal of colloid and interface science》2012,384(1):73-80
Ginsenoside Ro (Ro), a natural anionic biosurfactant derived from ginseng, has been found to markedly increase the solubility of saikosaponin a (SSa), which is the active ingredient of Radix Bupleuri. SSa is minimally soluble in water. To determine the mechanism by which Ro solubilizes SSa, the self-assembly behavior of Ro and the phase behavior of blended Ro and SSa systems were studied by mesoscopic dynamics (MesoDyn) and dissipative particle dynamics (DPD) simulations. The simulation results show that Ro can form vesicles via the closure of oblate membranes. At low concentrations, SSa molecules are solubilized in the palisade layer of the Ro vesicles. At high concentrations, they interact with Ro molecules to form mixed vesicles with Ro adsorbing on the surfaces of the vesicles. The evaluation of the SSa solubilization process reveals that, at low concentrations, Ro aggregates preferentially to form vesicles, which then absorb SSa into themselves. However, at high concentrations, SSa first self-aggregates and then dissolves. This is because the solubilization behavior of Ro shifts the precipitation-dissolution equilibrium in the direction of dissolution. These results of the simulations are consistent with those of transmission electron microscopy (TEM) and dynamic light scattering (DLS). 相似文献