全文获取类型
收费全文 | 339篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
化学 | 182篇 |
晶体学 | 4篇 |
力学 | 4篇 |
数学 | 68篇 |
物理学 | 91篇 |
出版年
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 5篇 |
2020年 | 9篇 |
2019年 | 7篇 |
2018年 | 8篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 11篇 |
2014年 | 11篇 |
2013年 | 15篇 |
2012年 | 17篇 |
2011年 | 29篇 |
2010年 | 11篇 |
2009年 | 8篇 |
2008年 | 18篇 |
2007年 | 18篇 |
2006年 | 14篇 |
2005年 | 10篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 19篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 10篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1981年 | 3篇 |
1975年 | 3篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1967年 | 2篇 |
1959年 | 3篇 |
1958年 | 3篇 |
1956年 | 5篇 |
1948年 | 3篇 |
1947年 | 5篇 |
1946年 | 4篇 |
1944年 | 2篇 |
排序方式: 共有349条查询结果,搜索用时 31 毫秒
341.
J. Jayabharathi P. Ramanathan V. Thanikachalam A. Arunpandiyan 《Journal of fluorescence》2014,24(3):827-834
The novel photoinduced electron transfer (PET) chemosensor, 1-(1-(4-methoxyphenyl)-1H-phenanthro[9,10-d]imidazol-2-yl)naphthalen-2-ol [MPPN] and its zinc complex were synthesised and characterized by electronic spectral and Frontier molecular orbital energy analysis. MPPN becomes efficient fluorescent chemosensor upon binding with metal ions and shows a strong preference toward Zn2+ ion. Density Functional theory (DFT) calculations reveal that luminescence of free MPPN originates from its orbital structure in which two π-orbitals (HOMO and HOMO-1) of the imidazole ring are situated between two π-orbitals (HOMO-2 and LUMO) of the naphthyl fragment. Therefore the absorption and emission processes occur between the two π- orbitals (HOMO-2 and LUMO). The two higher energy imidazole orbitals (HOMO and HOMO-1 ) serve as quenchers for the excited state of the molecule through nonradiative processes. Upon binding with Zn2+ ion, MPPN becomes a highly luminescent with λemi???421 nm. The significant enhancement of luminescence upon binding with Zn2+ ion is attributed to the stabilization of HOMO-2 and HOMO-1 π-orbitals of imidazole ring upon their engagement in new bonds with Zn2+ ion. The affinity of MPPN to zinc ion is found to be very high [K?=?6?×?106 M?1] when compared with other metals ions. The nonlinear absorption coefficient γ for MPPN is 1.9?×?10?12 m/W and 3.9?×?10?11 m/W for MPPN-Zn complex. 相似文献
342.
Kurzyński P Paterek T Ramanathan R Laskowski W Kaszlikowski D 《Physical review letters》2011,106(18):180402
We present a method to derive Bell monogamy relations by connecting the complementarity principle with quantum nonlocality. The resulting monogamy relations are stronger than those obtained from the no-signaling principle alone. In many cases, they yield tight quantum bounds on the amount of violation of single and multiple qubit correlation Bell inequalities. In contrast with the two-qubit case, a rich structure of possible violation patterns is shown to exist in the multipartite scenario. 相似文献
343.
Activation of imide carbonyl group with trifluoromethanesulfonic acid facilitates the intramolecular cyclization of phenethylphthalimides to give a fused isoindoloisoquinolinone skeleton. The first one pot regioselective synthesis of isoindoloisoquinolinone alkaloid (±)-nuevamine has been successfully executed using this methodology. 相似文献
344.
Yan‐Hui Liu Lata Ramanathan Bruce Malcolm George Njoroge Tin‐Yau Chan Birendra N. Pramanik 《Journal of mass spectrometry : JMS》2011,46(8):764-771
An affinity‐selection study using size exclusion chromatography (SEC) combined with off‐line electrospray ionization mass spectrometry (ESI‐MS) was performed on libraries of peptidic α‐ketoamide inhibitors directed against the hepatitis C virus (HCV) NS3 protease. A limiting amount of HCV NS3 protease (25 µM ) was incubated with equimolar amounts (100 µM ) of 49 reversible mechanism‐based ketoamide inhibitors, previously grouped into seven sets to ensure clearly distinguishable mass differences of the enzyme‐inhibitor complexes (>10 Da). The unbound compounds were separated rapidly from the protease and the protease‐inhibitor complexes by SEC spin columns. The eluate of the SEC was immediately analyzed by direct‐infusion ESI‐MS. An enzyme‐inhibitor complex, with a molecular mass corresponding to the NS3 protease binding to the preferred inhibitor, SCH212986, was the only molecular species detected. By increasing the molar ratio of HCV NS3 protease to inhibitors to 1:2 while keeping the inhibitors' concentration constant, the complex of the second most tightly bound inhibitor, SCH215426, was also identified. Although the potencies of these inhibitors were virtually un‐measurable by kinetic assays, a rank order of CVS4441 > SCH212986 > SCH215426 was deduced for their inhibition potencies by direct competition experiment with CVS4441 ( M ). As discussed in the article, through judicious application of this strategy, even large libraries of fairly weak, reversible and slow‐binding inhibitors could be rapidly screened and rank ordered to provide critical initial structure‐activity insights. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
345.
Ramanathan R Jemal M Ramagiri S Xia YQ Humpreys WG Olah T Korfmacher WA 《Journal of mass spectrometry : JMS》2011,46(6):595-601
It can be argued that the last true paradigm shift in the bioanalytical (BA) arena was the shift from high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection to HPLC with tandem mass spectrometry (MS/MS) detection after the commercialization of the triple quadrupole mass spectrometer in the 1990s. HPLC-MS/MS analysis based on selected reaction monitoring (SRM) has become the gold standard for BA assays and is used by all the major pharmaceutical companies for the quantitative analysis of new drug entities (NCEs) as part of the new drug discovery and development process. While LC-MS/MS continues to be the best tool for drug discovery bioanalysis, a new paradigm involving high-resolution mass spectrometry (HRMS) and ultrahigh-pressure liquid chromatography (uHPLC) is starting to make inroads into the pharmaceutical industry. The ability to collect full scan spectra, with excellent mass accuracy, mass resolution, 10-250 ms scan speeds and no NCE-related MS parameter optimization, makes the uHPLC-HRMS techniques suitable for quantitative analysis of NCEs while preserving maximum qualitative information about other drug-related and endogenous components such as metabolites, degradants, biomarkers and formulation materials. In this perspective article, we provide some insight into the evolution of the hybrid quadrupole-time-of-flight (Qq-TOF) mass spectrometer and propose some of the desirable specifications that such HRMS systems should have to be integrated into the drug discovery bioanalytical workflow for performing integrated qualitative and quantitative bioanalysis of drugs and related components. 相似文献
346.
Ramanathan R O'Mullane AP Parikh RY Smooker PM Bhargava SK Bansal V 《Langmuir : the ACS journal of surfaces and colloids》2011,27(2):714-719
We show for the first time that by controlling the growth kinetics of Morganella psychrotolerans, a silver-resistant psychrophilic bacterium, the shape anisotropy of silver nanoparticles can be achieved. This is particularly important considering that there has been no report that demonstrates a control over shape of Ag nanoparticles by controlling the growth kinetics of bacteria during biological synthesis. Additionally, we have for the first time performed electrochemistry experiments on bacterial cells after exposing them to Ag(+) ions, which provide significant new insights about mechanistic aspects of Ag reduction by bacteria. The possibility to achieve nanoparticle shape control by using a "green" biosynthesis approach is expected to open up new exciting avenues for eco-friendly, large-scale, and economically viable shape-controlled synthesis of nanomaterials. 相似文献
347.
Jayanthi S Sinha N Ramanathan KV 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2010,207(2):206-212
Separated Local Field (SLF) spectroscopy is a powerful tool for the determination of structure and dynamics of oriented systems such as membrane proteins oriented in lipid bilayers and liquid crystals. Of many SLF techniques available, Polarization Inversion Spin Exchange at Magic Angle (PISEMA) has found wide application due to its many favorable characteristics. However the pulse sequence suffers from its sensitivity to proton resonance frequency offset. Recently we have proposed a new sequence named 2(4)-SEMA (J. Chem. Phys. 132 (2010) 134301) that overcomes this problem of PISEMA. The present work demonstrates the advantage of 2(4)-SEMA as a highly sensitive SLF technique even for very large proton offset. 2(4)-SEMA has been designed for obtaining reliable dipolar couplings by switching the magic-angle spin-lock for protons over four quadrants as against the use of only two quadrants in PISEMA. It is observed that for on-resonance condition, 2(4)-SEMA gives rise to signal intensity comparable to or slightly higher than that from PISEMA. But under off-resonance conditions, intensities from 2(4)-SEMA are several fold higher than those from PISEMA. Comparison with another offset compensated pulse sequence, SAMPI4, also indicates a better intensity profile for 2(4)-SEMA. Experiments carried out on a single crystal of (15)N labeled N-acetyl-dl-valine and simulations have been used to study the relative performance of the pulse sequences considered. 相似文献
348.
Dr. Bathini Veeraprakash Dr. Gallelli Pratap Dr. Nitin P. Lobo Prof. Krishna V. Ramanathan Dr. Tanneru Narasimhaswamy 《Chemphyschem》2023,24(12):e202300074
Structurally simple rod-like π-conjugated mesogens with thiophene directly connected to phenyl, biphenyl, and fluorenone rings with terminal chains are synthesized respectively. The occurrence of smectic A/smectic C phases is concurred by a hot-stage optical polarising microscope (HOPM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The static 1D and 2D 13C nuclear magnetic resonance (NMR) studies in the liquid crystalline phase are carried out to find the alignment-induced chemical shifts (AIS) and 13C−1H dipolar couplings. The orientational order parameters of the mesogens determined from 13C−1H dipolar couplings disclose that the long axis is not only collinear to the C3−C4 bond of the thiophene ring but also for the local axes of phenyl and biphenyl rings. For fluorenone-based mesogen, the molecular biaxiality is found to be high owing to the increased breadth of the molecule. The study unveils that the orientation of thiophene and the phenyl rings is similar in the current mesogens in stark contrast to mesogens, where thiophene is connected to phenyl rings through linking groups. 相似文献
349.
Quantum wave packet dynamics of the Li(2S)+HCl( ) reaction in its electronic ground state is studied. The initial state-selected and energy-resolved dynamical attributes such as reaction probability, integral cross section, and thermal rate constant for the Cl-abstraction and H-abstraction pathways are reported. All partial wave contributions of J up to 120 were found to be necessary for the title reaction up to the collision energy of ∼1.0 eV. The dynamical results reveal that the Cl-abstraction is more favored over the H-abstraction for the different rovibrational (v, j) excitations. Due to the existence of an early barrier in the potential energy surface, the cross sections increase with increasing collision energy. The rate constants also monotonously increase with temperature for both channels. Resonances are identified and characterized in terms of eigenfunctions and lifetimes. Nearly 120 well-resolved eigenstates are reported for the LiHCl complex, and they are categorized as van der Waals (vdW), barrier and product states according to the nodal progressions along (R, r, γ). The vdW resonances reveal a local-mode behavior of quasibound type at low energies and extended progressions at high energies. Further, the single-quantized periodic orbit type is also observed in the barrier region, which decays very fast. Finally, the lifetime analysis reveals that the vdW resonances can survive as long as ∼2.2 ps, which is much longer than the lifetime of the resonances in the barrier region. 相似文献