Finite groups in which permutability is a transitive relation on their frattini factor groups

Let G be a finite group. A PT-group is a group G whose subnormal subgroups are all permutable in G. A PST-group is a group G whose subnormal subgroups are all S-permutable in G. We say that G is a PT_o-group (respectively, a PST_o-group) if its Frattini quotient group G/Φ(G) is a PT-group (respectively, a PST-group). In this paper, we determine the structure of minimal non-PT_o-groups and minimal non-PST_o-groups.      

Straightforward synthesis,antiproliferative screening,and density functional theory study of some pyrazolylpyrimidine derivatives

Tetrahydropyrimidinone derivative was synthesized through one-pot three components condensation of 1,3-diphenylpyrazole-4-carbaldehyde with pentan-2,4-dione and urea under Biginelli reaction conditions. The corresponding chloro- and hydrazino derivatives were synthesized and utilized for the construction of some valuable N-heterocycles encompassing both pyrazole and pyrimidine cores, such as triazolopyrimidine, tetrazolopyrimidine, pyrazole, and pyrazolone derivatives through condensation with nitrogen nucleophiles and carbon electrophiles. The antiproliferative activity evaluation of the synthesized compounds against four human carcinoma cell lines namely, liver carcinoma (HepG2), breast adenocarcinoma (MCF7), prostate cancer (PC3), and colon cancer (HCT-116) cell lines revealed that some of them provided significant potency, as well as the density-functional theory (DFT) was studied. The permeability of various hydrophilic and hydrophobic synthesized compounds across both normal and cancer cells is confirmed via DFT simulation in which the much higher permeability through aquaporin channels revealed the selective cytotoxicity toward cancer cells.     

Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber Holothuria spinifera: In Vitro and In Silico Studies

Chemical investigation of the methanolic extract of the Red Sea cucumber Holothuria spinifera led to the isolation of a new cerebroside, holospiniferoside (1), together with thymidine (2), methyl-α-d-glucopyranoside (3), a new triacylglycerol (4), and cholesterol (5). Their chemical structures were established by NMR and mass spectrometric analysis, including gas chromatography–mass spectrometry (GC–MS) and high-resolution mass spectrometry (HRMS). All the isolated compounds are reported in this species for the first time. Moreover, compound 1 exhibited promising in vitro antiproliferative effect on the human breast cancer cell line (MCF-7) with IC₅₀ of 20.6 µM compared to the IC₅₀ of 15.3 µM for the drug cisplatin. To predict the possible mechanism underlying the cytotoxicity of compound 1, a docking study was performed to elucidate its binding interactions with the active site of the protein Mdm2–p53. Compound 1 displayed an apoptotic activity via strong interaction with the active site of the target protein. This study highlights the importance of marine natural products in the design of new anticancer agents.     

Complex Envelope Crank-Nicolson Nearly PML Algorithm for the Left-handed Material FDTD Simulations

Unconditionally stable complex envelope (CE) absorbing boundary conditions (ABCs) are presented for truncating left handed material (LHM) domains. The proposed algorithm is based on incorporating the Crank Nicolson (CN) scheme into the CE finite difference time domain (FDTD) implementations of the nearly perfectly matched layer (NPML) formulations. The validity of the formulations is shown through numerical example carried out in one dimensional Lorentzian type LHM FDTD domain.     

Fe3+-hydroxamate as immobilized metal affinity-adsorbent for protein chromatography

The adsorbent glycinehydroxamate-Sepharose 6B, charged with Fe3+ under specified conditions, is reported. It was used at various pH values for chromatography of the following proteins: lysozyme, cytochrome c, avidin, bovine pancreatic RNase, myoglobin, ovalbumin and human serum albumin. The common naturally occurring amino acids were tested for their interactions with the new sorbent under neutral conditions.     

1H and 13C NMR Spectra of Alditolyl Derivatives of 3-Hydrazino-5-Methyl[1,2,4]triazino[5,6-b]indole and Their Cyclized Products.

The ¹H and ¹³C NMR spectra of sugar (5-methyl [1, 2, 4]-triazino [5, 6-b] indol-3-yl) hydrazones (1), per-0-acetyl aldehydo sugar 1-acetyl-1-(5-methyl [1, 2, 4] triazino [5, 6-b]-indol-3-yl) hydrazones (2), l- (penta-0-acetyl-pentitol-1-yl)-10-methyl [l, 2, 4] triazolo [3′, 4′:3, 4] [l, 2, 4] triazino [5, 6-b]-indoles (3) have been investigated. The 2 D NMR (H, C COSY) spectrum of 2a has been studied.     

Synthesis and characterisation of complexes of iron(II,III), cobalt(II,III) and nickel(II) with dinitrosoresorcinol

Summary Complexes of Fe^II, Fe^III, Co^II, Co^III and Ni^II with dinitroso resercinol (DNR) have been isolated and characterised. Ni studies showed that the metals are coordinated to the oxygens of one hydroxyl and one nitroso group, the second hydroxyl and nitroso groups remaining uncoordinated. The magnetic moments of the Fe^II and Ni^II complexes are commensurate with tetrahedral (or disorted octahedral) structures, while the others are ocahedral, however, the electronic spectra suggest ocahedral stereochemistries for all the complexes.     

Heterocycles. Part XII. Synthesis of new benzo[6,7]cyclohepta[1,2-d]pyrimidine

Selected 2-arylidene-1-benzosuberones I were condensed with guanidine hydrochloride to give the corresponding substituted 2-aminopyrimidines II and III respectively. Condensation of chalcones I with benz-amidine hydrochloride revealed the formation of the corresponding substituted 2-phenylpyrimidines IV. The structure of all products was substantiated by chemical and spectroscopic methods.     

Metal chelates of azo-pyridazine dyes III chelating tendencies of pyruvic and hippuric monohydrazone-3-hydrazino-4-benzyl-6-phenylpyridazine

The synthesis and quantitative equilibrium studies of two new azo-pyridazine ligands, namely the pyruvic (PHP) and hippuric (HipHP) acid derivatives are described in detail. Their acid-base and metal-ligand equilibrium constants in 75% dioxan-water solvent at 30 °C have been calculated from potentiometric and spectrophotometric data. The probable structures are inferred from electronic and vibrational spectral results. Evidence is presented for the formation of protonated complexes withPHP.

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Metall-Chelate von Azo-pyridazin-Farbstoffen, 3. Mitt.: Chelationsvermögen von Monohydrazon-3-hydrazino-4-benzyl-6-phenylpyridazin-Derivaten der Brenztrauben-und Hippursäure

Zusammenfassung Die Synthese und quantitative Gleichgewichtsuntersuchungen von zwei neuen Azo-pyridazin-Liganden, die von Brenztraubensäure (PHP) bzw. Hippursäure (HipHP) abzuleiten sind, werden im Detail beschrieben. Die entsprechenden Säure-Base- und Metall-Ligand-Gleichgewichtskonstanten in 75% Dioxan-Wasser bei 30 °C wurden aus potentiometrischen und spektrophotometrischen Daten ermittelt. Die wahrscheinlichen Strukturen wurden von Elektronen- und IR-spektroskopischen Daten abgeleitet. Es sind Beweise vorhanden, daß mitPHP protonierte Komplexe gebildet werden.