Lansoprazole,an antiulcerative drug

Lansoprazole, 2‐({[3‐methyl‐4‐(2,2,2‐trifluroethoxy)­pyri­din‐2‐yl]­methyl}­sulfinyl)‐1H‐benz­imidazole, C₁₆H₁₄F₃N₃O₂S, is an antiulcerative agent. The mol­ecules in the lattice are held together by intermolecular hydrogen bonds between the NH group of benz­imidazole and the sulfinyl O atom.     

Novel methodologies for the synthesis of functionalized lipophilic carboranes

Novel synthetic protocols for the synthesis of lipophilic carboranes were developed utilizing two C? C bond forming reactions, namely Baylis–Hillman and enynedioate cycloaddition reactions. Some of these carboranes were converted into further functionalized carboranes via nucleophilic allylic isomerization. Copyright © 2009 John Wiley & Sons, Ltd.     

Synthesis of R(+)-α-Lipoic Acid

An efficient enantiospecific synthesis of R(+)-α-Lipoic acid (1) a prosthetic group and a vital cofactor in -α-keto acids decarboxylation is described.     

Finite temperature vibronic spectra of harmonic surfaces: a time-dependent coupled cluster approach

An algorithm to compute vibronic spectra of harmonic surfaces including Dushinsky rotation and Hertzberg–Teller terms is described. The method, inspired by thermo field dynamics, maps the thermal density matrix onto the vacuum state and uses the time-dependent coupled cluster ansatz to propagate it in time. In the Franck–Condon approximation where the dipole matrix elements are taken to be constants, this reduces to the auto correlation function of the new vacuum. In the Hertzberg–Teller approximation, the full time evolution operator is needed. This too is governed by a closed set of equations. The theoretical development is presented along with an application to anthracene.     

Effect of phase transformation on optical and dielectric properties of zirconium oxide nanoparticles

Zirconium oxide nanoparticle (ZrO₂) is synthesized by the hydrothermal method at different calcination temperatures. The structural analysis is carried out by X-ray diffraction and Raman spectra. The sample prepared at 400 °C and 1100 °C showed the cubic and monoclinic phase, respectively, and the sample calcined at 600 °C and 800 °C showed the mixed phase with co-existence of cubic and monoclinic phases. Furthermore, the morphology and particle size of these samples were investigated by scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis. The band gap estimated from UV–Vis spectra of ZrO₂ (zirconia) nanocrystalline materials calcined at different temperatures from 400 °C to 1100 °C was in the range of 2.6–4.2 eV. The frequency dependence of dielectric constant and dielectric loss was investigated at room temperature. The low frequency region of dielectric constant is attributed to space charge effects.     

Three structures of dispirooxindole derivatives generated in situ through a three‐component one‐pot strategy with complete regio‐ and stereoselectivity

The challenging molecular architecture of spirooxindoles is appealing to chemists because it evokes novel synthetic strategies that address configurational demands and provides platforms for further reaction development. The [3+2] cycloaddition of the carbonyl ylide with arylideneoxindole via a five‐membered cyclic transition state gave a novel class of dispirooxindole derivatives, namely tert‐butyl 4′‐(4‐bromophenyl)‐1′′‐methyl‐2,2′′‐dioxo‐5′‐phenyl‐4′,5′‐dihydrodispiro[indoline‐3,2′‐furan‐3′,3′′‐indoline]‐1‐carboxylate, C₃₆H₃₁BrN₂O, (Ia), 5′‐(4‐bromophenyl)‐1,1′′‐dimethyl‐4′‐phenyl‐4′,5′‐dihydrodispiro[indoline‐3,2′‐furan‐3′,3′′‐indoline]‐2,2′′‐dione, C₃₂H₂₅BrN₂O₃, (Ib), and tert‐butyl 1′′‐methyl‐2,2′′‐dioxo‐4′‐phenyl‐5′‐(p‐tolyl)‐4′,5′‐dihydrodispiro[indoline‐3,2′‐furan‐3′,3′′‐indoline]‐1‐carboxylate, C₃₇H₃₄N₂O₅, (Ic). Crystal structure analyses of these dispirooxindoles revealed the formation of two diastereoisomers selectively and confirmed their relative stereochemistry (SSSR and RRRS). In all three structures, intramolecular C—H...O and π–π interactions between oxindole and dihydrofuran rings are the key factors governing the regio‐ and stereoselectivity, and in the absence of conventional hydrogen bonds, their crystal packings are strengthened by intermolecular C—H...π interactions.     

Natural convection heat transfer from a thin rectangular fin with a line source at the base — a finite difference solution

This paper presents an analysis of the problem of a thin fin of finite thermal conductivity, with an isothermal line source at the base, dissipating heat to the surrounding air by natural convection. The horizontal surface to which the fin is attached is adiabatic so that heat is dissipated only through the fin. The temperature and velocity distributions in the field, the temperature profile in the fin, local Nusselt numbers along the fin and the average heat transfer coefficient of the fin are obtained by solving the governing equations in the field and the heat transfer equation in the fin simultaneously, using an explicit unsteady Finite Difference formulation leading to the steady state result. Numerical experiments are performed to study the influence of parameters namely the fin height, temperature of the heating source and the fin material on the average heat transfer coefficient. Comparison is made with fins of infinite thermal conductivity and the vertical isothermal flat plate.     

Horizontal boundary-layer natural convection in a porous medium saturated with a gas

Boundary-layer analysis is performed for free convection flow over a hot horizontal surface embedded in a porous medium saturated with a gas of variable properties. The variable gas properties are accounted for via the assumption that thermal conductivity and dynamic viscosity are proportional to temperature. A similarity solution is shown to exist for the case of constant surface temperature. Numerical results for the stream function, horizontal velocity, and temperature profiles within the boundary layer as well as for the mass of entrained gas, surface slip velocity, and heat transfer rate at different values of the wall-temperature parameter are presented. Asymptotic solutions for large heating are also available to support the numerical work.