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Julia Gatenyo Kevin Johnson Anuruddha Rajapakse Kent S. Gates Shlomo Rozen 《Tetrahedron》2012,68(43):8942-8944
Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H218OF·CH3CN in a fast, readily executed and high-yielding preparation of 1,2,4-benzotriazine 1,4-dioxides containing an 18O-label at the 4-oxide position. 相似文献