全文获取类型
收费全文 | 4928篇 |
免费 | 167篇 |
国内免费 | 15篇 |
专业分类
化学 | 3220篇 |
晶体学 | 61篇 |
力学 | 96篇 |
数学 | 667篇 |
物理学 | 1066篇 |
出版年
2022年 | 31篇 |
2021年 | 31篇 |
2020年 | 58篇 |
2019年 | 72篇 |
2018年 | 34篇 |
2017年 | 39篇 |
2016年 | 108篇 |
2015年 | 105篇 |
2014年 | 122篇 |
2013年 | 180篇 |
2012年 | 212篇 |
2011年 | 264篇 |
2010年 | 132篇 |
2009年 | 129篇 |
2008年 | 210篇 |
2007年 | 234篇 |
2006年 | 202篇 |
2005年 | 207篇 |
2004年 | 211篇 |
2003年 | 126篇 |
2002年 | 165篇 |
2001年 | 98篇 |
2000年 | 88篇 |
1999年 | 88篇 |
1998年 | 70篇 |
1997年 | 97篇 |
1996年 | 91篇 |
1995年 | 63篇 |
1994年 | 87篇 |
1993年 | 74篇 |
1992年 | 50篇 |
1991年 | 65篇 |
1990年 | 65篇 |
1989年 | 48篇 |
1988年 | 71篇 |
1987年 | 75篇 |
1986年 | 59篇 |
1985年 | 87篇 |
1984年 | 79篇 |
1983年 | 70篇 |
1982年 | 70篇 |
1981年 | 66篇 |
1980年 | 67篇 |
1979年 | 66篇 |
1978年 | 53篇 |
1977年 | 49篇 |
1976年 | 45篇 |
1975年 | 37篇 |
1974年 | 32篇 |
1973年 | 35篇 |
排序方式: 共有5110条查询结果,搜索用时 31 毫秒
991.
Dr. Anja Richter Dr. Rolf Rose Dr. Christian Hedberg Prof. Dr. Herbert Waldmann Dr. Christian Ottmann 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(21):6520-6527
Modulation of protein–protein interactions (PPIs) is a highly demanding, but also a very promising approach in chemical biology and targeted drug discovery. In contrast to inhibiting PPIs with small, chemically tractable molecules, stabilisation of these interactions can only be achieved with complex natural products, like rapamycin, FK506, taxol, forskolin, brefeldin and fusicoccin. Fusicoccin stabilises the activatory complex of the plant H+‐ATPase PMA2 and 14‐3‐3 proteins. Recently, we have shown that the stabilising effect of fusicoccin could be mimicked by a trisubstituted pyrrolinone (pyrrolidone1, 1 ). Here, we report the synthesis, functional activity and crystal structure of derivatives of 1 that stabilise the 14‐3‐3–PMA2 complex. With a limited compound collection three modifications that are important for activity enhancement could be determined: 1) conversion of the pyrrolinone scaffold into a pyrazole, 2) introduction of a tetrazole moiety to the phenyl ring that contacts PMA2, and 3) addition of a bromine to the phenyl ring that exclusively contacts the 14‐3‐3 protein. The crystal structure of a pyrazole derivative of 1 in complex with 14‐3‐3 and PMA2 revealed that the more rigid core of this molecule positions the stabiliser deeper into the rim of the interface, enlarging especially the contact surface to PMA2. Combination of the aforementioned features gave rise to a molecule ( 37 ) that displays a threefold increase in stabilising the 14‐3‐3–PMA2 complex over 1 . Compound 37 and the other active derivatives show no effect on two other important 14‐3‐3 protein–protein interactions, that is, with CRaf and p53. This is the first study that describes the successful optimisation of a PPI stabiliser identified by screening. 相似文献
992.
993.
Raghavendra Murthy X.Q. Wang Ricardo Perez Marc P. Mignolet Lanae A. Richter 《Journal of sound and vibration》2012,331(5):1097-1114
This paper presents the first results of a combined experimental–computational investigation focused on the validation of reduced order models of geometrically nonlinear structures in the presence of uncertainty. The validation approach considered here is based on the premise that the model is valid if the experimental results can be considered as random sample responses of the stochastic system of which the reduced order model is the mean. For the situation considered here, the power spectra of the experiments should lie within the 2nd and 98th percentiles of the response (forming the uncertainty band) of the stochastic model. Nominally clamped–clamped beams are considered to demonstrate the entire process. The construction of two mean reduced order models and their stochastic counterparts are first performed. Then, the validation effort is carried out by comparing experimentally obtained power spectra and their corresponding computational uncertainty bands. This process leads, for both reduced order models, to a very good representation of the important upper envelope (98th percentile) of the experimental data but a less good fit of the lower envelope (2nd percentile). 相似文献
994.
Alexander M. Breul Christian Pietsch Roberto Menzel Johann Schäfer Anke Teichler Martin D. Hager Jürgen Popp Benjamin Dietzek Rainer Beckert Ulrich S. Schubert 《European Polymer Journal》2012,48(7):1339-1347
Blue emitting dyes bearing a luciferin analogous chromophore were attached to a polystyrene backbone. For this purpose, 4-hydroxy-1,3-thiazoles were functionalized with a styrene unit and polymerized using the reversible addition–fragmentation chain transfer (RAFT) polymerization technique. Two different chain transfer agents were investigated and one monomer was studied in terms of its kinetic behavior. The polymerization kinetics are presented and discussed in detail, showing a controlled polymerization behavior, resulting in well-defined copolymers with polydispersity indices below 1.2. The obtained polymers were characterized by size exclusion chromatography (SEC), 1H NMR, MALDI-TOF MS and UV–vis absorption and fluorescence spectroscopy. In addition, the UV–vis absorption and emission behavior was investigated in thin films. 相似文献
995.
Masaaki Yoshifuji Yuichi Hirano Gregor Schnakenburg Rainer Streubel Edgar Niecke Shigekazu Ito 《Helvetica chimica acta》2012,95(10):1723-1729
1,3‐Di(tert‐butyl)‐2,4‐bis[2,4,6‐tri(tert‐butyl)phenyl]‐1,3‐diphosphacyclobutane‐2,4‐diyl was formed from [2,4,6‐tri(tert‐butyl)phenyl]phosphaacetylene and t‐BuLi. In addition, the X‐ray diffraction analysis was carried out, together with theoretical calculations of the structure and NMR data. 相似文献
996.
The indides Eu2Pd2In and Eu2Pt2In were synthesized from the elements in sealed tantalum tubes in an induction furnace. The samples were characterized by powder X‐ray diffraction. The structures were refined on the basis of single‐crystal X‐ray diffractometer data: HT‐Pr2Co2Al type, C2/c, a = 1035.7(2), b = 592.9(1), c = 823.6(2) pm, β = 104.26(1) °, wR2 = 0.026, 1075 F2 values, 25 variables for Eu2Pd2In and a = 1017.2(2), b = 588.7(1), c = 826.5(1) pm, β = 103.76(1) °, wR2 = 0.062, 706 F2 values, 25 variables for Eu2Pt2In. The indium atoms have four platinum (palladium) neighbors in strongly distorted tetrahedral coordination at Pt–In and Pd–In distances ranging from 273 to 275 pm. These InPd4/2 and InPt4/2 units are condensed via common edges to infinite InPd2 and InPt2 chains, which are surrounded by the europium atoms. The chains form the motif of hexagonal rod packing. 相似文献
997.
998.
Complexes of type C6H7(+)·L (L = N2 and CO2) studied by explicitly correlated coupled cluster theory
Complexes of the benzenium ion (C(6)H(7)(+)) with N(2) or CO(2) have been studied by explicitly correlated coupled cluster theory at the CCSD(T)-F12x (x = a, b) level [T. B. Adler et al., J. Chem. Phys. 127, 221106 (2007)] and the double-hybrid density functional B2PLYP-D [T. Schwabe and S. Grimme, Phys. Chem. Chem. Phys. 9, 3397 (2007)]. Improved harmonic vibrational wavenumbers for C(6)H(7)(+) have been obtained by CCSD(T?)-F12a calculations with the VTZ-F12 basis set. Combining them with previous B2PLYP-D anharmonic contributions we arrive at anharmonic wavenumbers which are in excellent agreement with recent experimental data from p-H(2) matrix isolation IR spectroscopy [M. Bahou et al., J. Chem. Phys. 136, 154304 (2012)]. The energetically most favourable conformer of C(6)H(7)(+)·N(2) shows a π-bonded structure similar to C(6)H(7)(+)·Rg (Rg = Ne, Ar) [P. Botschwina and R. Oswald, J. Phys. Chem. A 115, 13664 (2011)] with D(e) ≈ 870 cm(-1). For C(6)H(7)(+)·CO(2), a slightly lower energy is calculated for a conformer with the CO(2) ligand lying in the ring-plane of the C(6)H(7)(+) moiety (D(e) ≈ 1508 cm(-1)). It may be discriminated from other conformers through a strong band predicted at 1218 cm(-1), red-shifted by 21 cm(-1) from the corresponding band of free C(6)H(7)(+). 相似文献
999.
Bajo JJ González-Vázquez J Sola IR Santamaria J Richter M Marquetand P González L 《The journal of physical chemistry. A》2012,116(11):2800-2807
The dynamics of molecules under strong laser pulses is characterized by large Stark effects that modify and reshape the electronic potentials, known as laser-induced potentials (LIPs). If the time scale of the interaction is slow enough that the nuclear positions can adapt to these externally driven changes, the dynamics proceeds by adiabatic following, where the nuclei gain very little kinetic energy during the process. In this regime we show that the molecular dynamics can be simulated quite accurately by a semiclassical surface-hopping scheme formulated in the adiabatic representation. The nuclear motion is then influenced by the gradients of the laser-modified potentials, and nonadiabatic couplings are seen as transitions between the LIPs. As an example, we simulate the process of adiabatic passage by light induced potentials in Na(2) using the surface-hopping technique both in the diabatic representation based on molecular potentials and in the adiabatic representation based on LIPs, showing how the choice of the representation is crucial in reproducing the results obtained by exact quantum dynamical calculations. 相似文献
1000.
Silva AF Richter WE Meneses HG Faria SH Bruns RE 《The journal of physical chemistry. A》2012,116(31):8238-8249
Infrared fundamental intensities calculated by the quantum theory of atoms in molecules/charge-charge flux-dipole flux (QTAIM/CCFDF) method have been partitioned into charge, charge flux, and dipole flux contributions as well as their charge-charge flux, charge-dipole flux, and charge flux-dipole flux interaction contributions. The interaction contributions can be positive or negative and do not depend on molecular orientations in coordinate systems or normal coordinate phase definitions, as do CCFDF dipole moment derivative contributions. If interactions are positive, their corresponding dipole moment derivative contributions have the same polarity reinforcing the total intensity estimates whereas negative contributions indicate opposite polarities and lower CCFDF intensities. Intensity partitioning is carried out for the normal coordinates of acetylene, ethylene, ethane, all the chlorofluoromethanes, the X(2)CY (X = F, Cl; Y = O, S) molecules, the difluoro- and dichloroethylenes and BF(3). QTAIM/CCFDF calculated intensities with optimized quantum levels agree within 11.3 km mol(-1) of the experimental values. The CH stretching and in-plane bending vibrations are characterized by significant charge flux, dipole flux, and charge flux-dipole flux interaction contributions with the negative interaction tending to cancel the individual contributions resulting in vary small intensity values. CF stretching and bending vibrations have large charge, charge-charge flux, and charge-dipole flux contributions for which the two interaction contributions tend to cancel one another. The experimental CF stretching intensities can be estimated to within 31.7 km mol(-1) or 16.3% by a sum of these three contributions. However, the charge contribution alone is not successful at quantitatively estimating these CF intensities. Although the CCl stretching vibrations have significant charge-charge flux and charge-dipole flux contributions, like those of the CF stretches, both of these interaction contributions have opposite signs for these two types of vibrations. 相似文献