This paper focuses on the inverse problem regarding force localization in the case of impacts not concentrated at a point but which occur on elastic beams. Following the identification approach proposed to solve this problem and which is based on the reciprocity theorem, the impact location characteristics were determined by using particle swarm optimization algorithm. To eliminate numerical trouble due to the trivial solutions appearing in this formulation, the fitness function was customized by introducing a set of weighting coefficients. Four different formulations of the fitness function were considered and their performances with regards to the number of sensors used and their positions were analyzed. They enabled a selection of the best combination of weighting coefficients to be used in the context of an impact force localization process based on the particle swarm optimization technique. Three sensors were found to be required and comparison with a genetic algorithm has revealed the effectiveness of the proposed method in terms of accuracy and computational time. 相似文献
An efficient one-pot four-step domino reaction of substituted β-ketoesters has been optimized giving rise to a large panel of C2-substituted 3-methylcyclohex-2-enones, an important scaffold for the preparation of various initiators for cationic or radical cyclizations. The developed methodology is quite general and applicable to a wide range of β-ketoester substrates, allowing the introduction of various functionalities at the C2 position of the 3-methylcyclohex-2-enones, in good to excellent yields. 相似文献
This paper describes a new type of surface imprinting technique that combines the advantages of both the semi‐covalent approach and one‐stage miniemulsion polymerization. This process has been successfully applied for the preparation of glucose surface‐imprinted nanoparticles. The selective artificial receptors for glucopyranoside were fully characterized by IR, TEM and BET analyses, and their molecular recognition abilities by binding experiments carried out in batch processes. The molecular affinity and selectivity of the glucose molecularly imprinted polymers were accurately quantified. These characteristics are essential for verification of the efficiency of the developed surface imprinting process. The imprinting effect was clearly demonstrated using the batch rebinding method. We have found that the glucose imprinted polymers produced using the optimized one‐stage mini‐emulsion exhibited quite fast kinetics of binding and equilibration with glucopyranoside templates, compared to polymers prepared by bulk polymerization technique, as well as extremely low levels of unspecific bindings. We also demonstrated that glucose molecular imprinted polymer (MIP) exhibited very good selectivity for its original template compared to other glycopyranoside derivatives, such as galactose. Finally, the extraction of the binding properties from isotherms of binding by fitting to the bi‐Langmuir and Freundlich models allowed the determination of the affinity constant distribution of the binding sites. This imprinting protocol allowed the determination of an affinity constant (KD), involving exclusively H‐bonding interactions, for the glucose MIP ( P2C ) with the best template 1 , in CH3CN as the solvent system.
The jaspamide/chondramide family of depsipeptides are mixed PKS/NRPS natural products isolated from marine sponges and a terrestrial myxobacterium that potently affect the function of the actin cytoskeleton. As a first step to improve production in heterologous host cells and permit genetic approaches to novel analogs, we have cloned and characterized the chondramide biosynthetic genes from the myxobacterium Chondromyces crocatus Cm c5. In addition to the expected PKS and NRPS genes, the cluster encodes a rare tyrosine aminomutase for beta-tyrosine formation and a previously unknown tryptophan-2-halogenase. Conditions for gene transfer into C. crocatus Cm c5 were developed, and inactivation of several genes corroborated their proposed function and served to define the boundaries of the cluster. Biochemical characterization of the final NRPS adenylation domain confirmed the direct activation of beta-tyrosine, and fluorinated chondramides were produced through precursor-directed biosynthesis. 相似文献
The first synthesis of cytotoxic (-)-taiwaniaquinone A and (-)-taiwaniaquinone F has been achieved through the intramolecular aldol condensation of a ketoaldehyde and the oxidative cleavage of an isopropylidene ketal. 相似文献
Mono-, di-, and trinitro tricarboxymethyl calix[6]arenes 3(a-c) have been synthesised and their acid-base behaviour determined by potentiometric investigations. It was shown that the nitro groups do not play a major role on the acid-base properties. Preliminary complexation of uranyl is presented. 相似文献
Direct or Ni-catalysed electroreductive homocouplings of organic halides and couplings of organic halides with activated olefins are efficiently conducted by constant current electrolyses in an undivided cell in room-temperature ionic liquids as the solvent-electrolyte media. 相似文献
Ethyl α-cyano-4-(methacryloxy)cinnamate was synthesized to prepare new photosensitive polymers. Homopolymerization and copolymerizations were carried out in solution in chloroform at 65 °C using AIBN as an initiator. Methyl methacrylate was chosen as comonomer for the studies of copolymerzation. The structures formed were characterized by IR and 1H NMR spectroscopies. The values of reactivity ratios of the comonomers calculated according to the Finneman-Ross method indicated that the reactivity of the synthesized photosensitive monomer is lower than that of MMA. Thin films of the obtained polymers were prepared to study their ability to crosslink under UV irradiation. The photodimerization of the cinnamate moieties was characterized. 相似文献
To evaluate the risk of contaminant transport by mobile colloids, it seems essential to understand how colloids and associated pollutants behave during their migration through uncontaminated soil or groundwater. In this study, we investigated at pH 4 the influence of flow velocity, humic acid, solution Ca(2+) concentrations, and trace metals (Pb(2+), Cu(2+)) on the transport and deposition of kaolinite particles through a pure crystalline quartz sand as porous medium. A short-pulse chromatographic technique was used to measure colloid deposition. Adsorption of humic acid to the kaolinite increase its negative surface charge and then decrease colloid deposition. Experiments with different flow rates showed that humic-coated kaolinite colloid deposition followed a first-order kinetic rate law. The deposition rate coefficients of humic-coated kaolinite colloids increase with increasing Ca(2+) concentration in the suspension. The effect of trace metals on the mobility is studied by injecting two suspensions with different concentrations of Pb(2+) and Cu(2+). At very low cation concentration, the fraction of colloids retained is low and roughly independent of the nature of divalent cations. At high concentration, the deposition is higher and depends on the affinity of divalent cations toward humic-coated kaolinite colloids. 相似文献