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991.
Bui?Van Thanh Do?N?Dai Tran?D?ThangEmail author Nguyen?Q?Binh Luu?D?Ngoc?Anh Isiaka?A?Ogunwande 《Chemistry Central journal》2014,8(1):54
Background
Vietnam is a country blessed with many medicinal plants widely used as food and for medicinal purposes, and they contain a host of active substances that contribute to health. However, the analysis of chemical constituents of these plant species has not been subject of literature discussion.Results
In this study, the chemical compositions of essential oils of four Hedychium species, obtained by hydrodistillation, were determined by means of gas chromatography-flame ionization detector (GC-FID) and gas chromatography–mass spectrometry (GC-MS) techniques. Individually, α-pinene (52.5%) and β-pinene (31.8%) were present in the leaf oil of Hedychium stenopetalum Lodd., while linalool (45.2%), (E)-nerolidol (8.7%) and α-pinene (5.0%) were identified in the root. The leaf of Hedychium coronarium J. König was characterized by α-pinene (20.0%), linalool (15.8%), 1,8-cineole (10.7%), α-pinene (10.1%) and α-terpineol (8.6%); while α-pinene (23.6%), α-humulene (17.1%) and β-caryophyllene (13.0%) were identified in the root. Hedychium flavum Roxb., gave oil whose major compounds were α-pinene (22.5%), α-humulene (15.7%) and β-caryophyllene (10.4%) in the leaf; α-humulene (18.9%), β-caryophyllene (11.8%) and α-pinene (11.2%) in the stem, as well as α-pinene (21.8%), linalool (17.5%) and 1,8-cineole (13.5%) in the root. The main constituents of Hedychium ellipticum Buch.-Ham. ex Smith were (E)-nerolidol (15.9%), α-pinene (11.8%) and bornyl acetate (9.2%) in the leaf with 1,8-cineole (40.8%), α-pinene (18.3%) and α-pinene (11.0%) occurring in the root.Conclusions
Ubiquitous monoterpenes and sesquiterpenes were identified as characteristic markers for Hedychium species. This work is of great importance for the evaluation of Hedychium essential oils grown in Vietnam.992.
Daniela E. Ortega Quynh Nhu N. Nguyen Dean J. Tantillo Alejandro Toro‐Labbé 《Journal of computational chemistry》2016,37(12):1068-1081
Caryolene formation occur asynchronously in a concerted way through carbocationic rearrangements involving the generation of a secondary or a tertiary carbocation whether the reaction proceeds in the absence or in the presence of NH3, respectively. Both caryolene formation mechanisms are analyzed within the general framework of the reaction force; the reaction force constant is used to gain insights into the synchronicity of the mechanisms and the reaction electronic flux helps to characterize the electronic activity taking place during the reaction. DFT calculations at the B3LYP/6‐31+G(d,p) level show a clear difference in the mechanisms of the base promoted or base free caryolene formation reactions. © 2016 Wiley Periodicals, Inc. 相似文献
993.
Johannes C. B. Dietschreit Annika Wagner T. Anh Le Philipp Klein Hermann Schindelin Till Opatz Bernd Engels Ute A. Hellmich Christian Ochsenfeld 《Angewandte Chemie (International ed. in English)》2020,59(31):12669-12673
The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical‐shift predictions to deduce ligand‐binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleeping sickness. We include many protein–inhibitor conformations as well as monomeric and dimeric inhibitor–protein complexes, thus rendering it the largest computational study on chemical shifts of 19F nuclei in a biological context to date. Our predicted shifts agree well with those obtained experimentally and pave the way for future work in this area. 相似文献
994.
The capillary rise of liquids was investigated in square capillary tubings of different dimensions (e. g. 300 m · 300 m to 1000 m · 1000 m) in the temperature range 25° to 35°C.The data were fitted to an equation:=1/2 · ·g · (S · (C ·H/2 +C ·S)) where is the surface tension of the liquid,S is the side length of the square tubing,H is the capillary rise,C (= 1.089) is a capillary constant. 相似文献
995.
Boris M. Mandić Marina D. Vlajić Snežana S. Trifunović Milena R. Simić Ljubodrag V. Vujisić Ivan M. VuČković 《Natural product research》2015,29(9):887-890
Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC–MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1 M sulphuric acid (30 mL per 1.00 g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30 mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs. 相似文献
996.
Le Tuan Anh K. B. Polyanskii A. N. Andresyuk A. T. Soldatenkov Zh. A. Mamyrbekova L. N. Kuleshova V. N. Khrustalev 《Russian Chemical Bulletin》2004,53(4):842-845
Condensation of arylboronic acids with 4-hydroxy-3-(-hydroxybenzyl)-1-methyl-4-phenylpiperidine afforded 2,4,8a-triarylperhydro[1,3,2]dioxaborinino[5,4-c]pyridines. The molecular structure of 6-methyl-2,4,8a-triphenylperhydro[1,3,2]dioxaborinino[5,4-c]pyridine was established by X-ray diffraction analysis. 相似文献
997.
Nguyen?Dinh?ThanhEmail author Hoang?Thanh?Duc Vu?Thi?Duyen Phan?Manh?Tuong Nguyen?Van?Quoc 《Chemistry Central journal》2015,9(1):60
Background
Sydnone is a heterocycle that exhibits remarkable pharmacological activities, including antimicrobial, anti-inflammatory, analgesic, antipyretic and antioxidant activities. Thiosemicarbazones are of compounds that contain the –NHCSNHN=C< linkage group and are considerable interest because they exhibit important chemical properties and potentially beneficial biological activities. Similarly, thiosemicarbazones having carbohydrate moieties also exhibit various significant biological activities.Results
The compounds of 3-formyl-4-phenylsydnones were obtained by Vilsmeyer-Haack’s formylation reaction and were transformed into thiosemicarbazones by condensation reaction with N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazide. Reaction were performed in the presence glacial acetic acid as catalyst using microwave-assisted heating method. Reaction yields were 43?85 %. The antimicrobial activities of these thiosemicarbazones were screened in vitro by using agar well diffusion and MIC methods. Among these thiosemicarbazones, compounds 4k, 4l, 4m and 4n were more active against all tested bacterial strains, especially against S. epidermidis, B. subtilis and E. coli. The MIC values in these cases are 0.156, 0.156 and 0.313 μg/mL, respectively. All compounds showed weak to moderate antifungal activity against C. albicans and A. niger than nystatin (MIC = 0.156?0.625 μg/mL vs. MIC = 0.078 μg/mL of nystatin), and thiosemicarbazones 4l, 4m and 4n exhibited significant activity with MIC = 0.156 μg/mL. These compounds also had good antifungal activity against F. oxysporum similarly to nystatin (MIC = 0.156 μg/mL). Among the tested compounds having halogen group 4k, 4l, 4m and 4n showed highest activity against three strains of fungal organisms.Conclusions
In summary, we have developed a clean and efficient methodology for the synthesis of novel thiosemicarbazone derivatives bearing sydnone ring and d-glucose moiety; the heterocyclic and monosaccharide system being connected via ?NH?C(=S)NH?N=C< linker using molecular modification approach. The methodology could be further extended and used for the synthesis of other thiosemicarbazones of biological importance. 4-Formyl-3-arylsydnone N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones have been synthesized under microwave-assisted heating conditions. Almost all obtained compounds showed remarkable activities against the tested microorganisms. Among the tested compounds having halogen group 4k, 4l, 4m and 4n showed highest activity against all tested strains of bacterial and fungal organisms.998.
Carl-Johan Carling Mathieu L. Viger Viet Anh Nguyen Huu Arnold V. Garcia Adah Almutairi 《Chemical science》2015,6(1):335-341
Controlling chemistry in space and time has offered scientists and engineers powerful tools for research and technology. For example, on-demand photo-triggered activation of neurotransmitters has revolutionized neuroscience. Non-invasive control of the availability of bioactive molecules in living organisms will undoubtedly lead to major advances; however, this requires the development of photosystems that efficiently respond to regions of the electromagnetic spectrum that innocuously penetrate tissue. To this end, we have developed a polymer that photochemically degrades upon absorption of one photon of visible light and demonstrated its potential for medical applications. Particles formulated from this polymer release molecular cargo in vitro and in vivo upon irradiation with blue visible light through a photoexpansile swelling mechanism. 相似文献
999.
Hong Khanh Dieu Nguyen Toan Dang Nguyen Anh ThiPhuong Vu Thao Tien Nguyen 《Chemical Papers》2017,71(5):961-970
Acid–base bi-functional hydrotalcite like compounds based on partial incorporation of Al3+ into brucite structure of Mg(OH)2 with various molar ratios were prepared through co-precipitation method. The co-precipitation of the precursors produced precipitations followed by drying at 120 °C for 12 h and calcination in air flow at 500 °C for 6 h to obtain the catalysts (Mg–Al HLCs). Many techniques including XRD, TG–DTA, EDX, NH3-TPD, CO2-TPD, GC–MS and XANES were used to characterize and optimize Mg/Al molar ratio based on the thermal stability of the Mg–Al HLCs and their activities in decarboxylation process of coconut oil. The results showed that the best molar ratio of Mg/Al was 3/1 providing a stable hydrotalcite like structure, and the catalyst possessed both acid and base sites on its surface enhancing its activity and selectivity in the decarboxylation process. The catalysts revealed high performance in the decarboxylation process of coconut oil established at 400 °C for 4 h for green hydrocarbons belonging to kerosene fractions. 相似文献
1000.
Kristan S. Worthington Anh‐Vu Do Rasheid Smith Budd A. Tucker Aliasger K. Salem 《Macromolecular bioscience》2019,19(2)
Geometric topographies are known to influence cellular differentiation toward specific phenotypes, but to date the range of features and type of substrates that can be easily fabricated to study these interactions is somewhat limited. In this study, an emerging technology, two‐photon polymerization, is used to print topological patterns with varying feature‐size and thereby study their effect on cellular differentiation. This technique offers rapid manufacturing of topographical surfaces with good feature resolution for shapes smaller than 3 µm. Human‐induced pluripotent stem cells, when attached to these substrates or a non‐patterned control for 1 week, express an array of genetic markers that suggest their differentiation toward a heterogeneous population of multipotent progenitors from all three germ layers. Compared to the topographically smooth control, small features (1.6 µm) encourage differentiation toward ectoderm while large features (8 µm) inhibit self‐renewal. This study demonstrates the potential of using two‐photon polymerization to study and control stem cell fate as a function of substrate interactions. The ability to tailor and strategically design biomaterials in this way can enable more precise and efficient generation or maintenance of desired phenotypes in vitro and in vivo. 相似文献