Hard X-ray one dimensional nano-focusing at the SSRF using a WSi2 /Si multilayer Laue lens

The multilayer Laue lens (MLL) is a novel diffraction optics which can realize nanometer focusing of hard X-rays with high efficiency. In this paper, a 7.9 μm-thick MLL with the outmost layer thickness of 15 nm is designed based on dynamical diffraction theory. The MLL is fabricated by first depositing the depth-graded multilayer using direct current (DC) magnetron sputtering technology. Then, the multilayer sample is sliced, and both cross-sections are thinned and polished to a depth of 35-41 μm. The focusing property of the MLL is measured at the Shanghai Synchrotron Facility (SSRF). One-dimensional (1D) focusing resolutions of 205 nm and 221 nm are obtained at E=14 keV and 18 keV, respectively. It demonstrates that the fabricated MLL can focus hard X-rays into nanometer scale.     

2-NBDG Fluorescence Imaging of Hypermetabolic Circulating Tumor Cells in Mouse Xenograft model of Breast Cancer

Objectives

To determine use of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) as a tracer for detection of hypermetabolic circulating tumor cells (CTC) by fluorescence imaging.

Procedures

Human breast cancer cells were implanted in the mammary gland fat pad of athymic mice to establish orthotopic human breast cancer xenografts as a mouse model of circulating breast cancer cells. Near-infrared fluorescence imaging of the tumor-bearing mice injected with 2-DeoxyGlucosone 750 (2-DG 750) was conducted to assess glucose metabolism of xenograft tumors. Following incubation with fluorescent 2-NBDG, circulating breast cancer cells in the blood samples collected from the tumor-bearing mice were collected by magnetic separation, followed by fluorescence imaging for 2-NBDG uptake by circulating breast cancer cells, and correlation of the number of hypermetabolic circulating breast cancer cells with tumor size at the time when the blood samples were collected.

Results

Human breast cancer xenograft tumors derived from MDA-MB-231, BT474, or SKBR-3 cells were visualized on near-infrared fluorescence imaging of the tumor-bearing mice injected with 2-DG 750. Hypermetabolic circulating breast cancer cells with increased uptake of fluorescent 2-NBDG were detected in the blood samples from tumor-bearing mice and visualized by fluorescence imaging, but not in the blood samples from normal control mice. The number of hypermetabolic circulating breast cancer cells increased along with growth of xenograft tumors, with the number of hypermetabolic circulating breast cancer cells detected in the mice bearing MDA-MB231 xenografts larger than those in the mice bearing BT474 or SKBR-3 xenograft tumors.

Conclusions

Circulating breast cancer cells with increased uptake of fluorescent 2-NBDG were detected in mice bearing human breast cancer xenograft tumors by fluorescence imaging, suggesting clinical use of 2-NBDG as a tracer for fluorescence imaging of hypermetabolic circulating breast cancer cells.     

密集阵高功率微波空间功率合成

对基于矩形阵列的高功率微波二维密集阵阵列合成进行了研究。仿真分析了均匀矩形栅格阵列的远场方向图,结果表明采用密集阵可以实现高效的、具有确定主波束的空间功率合成。并分析了阵元间距及阵元初相位对阵列空间功率合成的影响,结果表明:阵元间距越小,栅瓣越少,主波束宽度越宽,具有确定主波束的临界距离越小;当目标高度超过阵临界距离时,阵元初相位相差越小合成效率越高,阵列初相位分布范围超过/2时,阵列得不到确定的主波束,进行阵列设计时应充分考虑阵元间距及初相位对阵列合成的影响。     

基于束流位置探测器的束团长度测量

分析了驱动电子束团的频域特性,研究了基于该特性进行长度测量的理论基础;使用三维模拟软件对束流位置探测器(BPM)进行建模,用模拟的方法对传输阻抗进行了数值计算;对不同长度的束团进行了测量和计算,并且分析了束团位置在真空管道中偏移对束团长度测量的影响。由测量结果可见,电子束团长度在10~100 ps(3~30 mm)时,测量误差均小于2%,满足中国工程物理研究院高平均功率自由电子激光太赫兹实验测量的使用要求。     

聚变反应时间历程的双峰结构测量

利用新研制的聚变反应速率测量系统,在神光Ⅲ原型装置上测量了间接驱动时充DT气体的玻璃球壳内爆靶丸的聚变反应速率的时间历程,获得了DT中子产额约为1010时的聚变反应速率随时间的变化过程,发现了聚变中子发射在时间上的双峰结构。利用辐射流体程序对聚变中子在时间上的双峰结构进行了数值模拟,发现双峰结构分别由冲击压缩过程和惯性压缩过程产生,靶丸壳层厚度不同时产生的聚变中子发射双峰强度比变化可能是由靶丸的初始表面调制度不同所致。通过理论模拟与实验结果的对比,验证了中子聚变反应历程的双峰结构。     

改进的三维电磁PIC系统模拟并行算法

为了更好地实现对大尺度器件的模拟,以及更系统地验证和解决高功率微波系统在设计和实验中负载变化等影响,在进一步深入研究电磁PIC并行算法的基础上,运用MPI消息传递函数做出了改进。提出了一种整体建模、分段解析的并行算法,并从并行时序算法入手,通过减少一次同步提高了计算的效率。最后经过一个磁绝缘线振荡器进行验证,改进的算法正确,并且当计算进程数4个增加到16个时,计算速度能提高2.5倍左右。     

楔形盒染料掺杂胆甾相液晶激光器研究

设计制作了楔形盒掺杂激光染料PM580的胆甾相液晶器件, 研究了激光辐射行为. 在楔形液晶盒中出现了一系列与楔棱平行的向错线和不同规则形状的晶畴, 胆甾相液晶形成了平面态排列. 采用固体Nd:YAG倍频532 nm 波长激光作为抽运光, 获得调谐精度约1 nm, 调谐范围约17 nm的一维波长可调谐激光器. 楔形盒中, 液晶扭曲力与取向膜表面锚定力相互平衡的过程中胆甾相液晶螺距伸张, 光子禁带位置移动, 从而调谐光子禁带边沿出射激光波长. 关键词： 胆甾相液晶 楔形盒 激光辐射     

色散补偿光子晶体光纤结构参数对其色散的影响

光子晶体光纤由于其灵活可调的色散特性用作色散补偿具有极大的应用潜力. 设计了一种色散补偿光子晶体光纤, 并运用频域有限差分法模拟了其色散特性,从理论上分析了其结构参数孔间距Λ和空气占空比d/Λ对该光子晶体光纤的色散系数的影响, 并且实际制备出了3种不同结构参数的光子晶体光纤. 通过对其色散曲线对比分析表明: 当光子晶体光纤孔间距在1 μm附近时, 其色散系数随着孔间距Λ和占空比d/Λ的增大而增加, 但对于孔间距Λ的变化比占空比d/Λ更为敏感, 并且随着孔间距Λ的增加,其对色散系数的影响能力逐渐减小. 设计并制备的光子晶体光纤在1550 nm处的色散系数为-241.5 ps·nm^-1·km^-1, 相对色散斜率为0.0018, 具有较好的色散补偿能力. 关键词： 色散 色散补偿 光子晶体光纤 结构参数     

GaN薄膜中的马赛克结构随厚度发生的变化

利用高分辨率X射线衍射(HRXRD)对MOCVD系统中生长在c面Al₂O₃上的不 同厚度的GaN薄膜内马赛克结构进行了研究. 在对称面的三轴X射线衍射曲线中, 用两种方法计算得到晶粒的垂直关联长度和水平关联长度, 两者均随着薄膜厚度的增加而增加, 并且垂直关联长度近似膜厚从倒易空间图中得出的横向关联长度也有相同的趋势, 结合非对称面的衍射曲线用Williamson-Hall方法和外推法分 别拟合出晶粒的面外倾斜角和面内扭转角, 他们随着薄膜厚度的增加显著减少, 这一切都表明厚度的增加, 晶粒的单向有序排列越来越整齐, 外延片的质量越来越高. 关键词： GaN薄膜马赛克结构 厚度 HRXRD     

热泵热水器变工况性能的无量纲对比态分析法

本文介绍一种热泵热水器性能的无量纲对比态分析法,该方法采用不同工况的热泵热水器性能参数与标准设计工况的参数对比的无量纲参数来描述实际工况性能。分别导出了理论和实际的描述热泵热水器变工况性能的无量纲表达式,给出了环境气温从-5～40℃,进水温度从5～30℃的无量纲性能曲线,以及两种型号的实验机的结霜温度区的实验结果无量纲对比性能。研究发现,热泵热水器的对比热水流量m_w是体现变工况性能的极为敏感和重要的参数,只有用m_w和COP相结合,才能全面反映热泵性能。