Quantum dynamics of dissociative adsorption of H_2 and D_2:The time-dependent wave packet method

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Analytical equilibrium gradient methods

Analytical equilibrium gradient methods are non-linear separation methods in which the separation mechanism involves a force gradient along the separation channel. These methods can be classified into two categories: those in which the gradient is a field gradient applied along the separation channel (i.e., field gradient), and those in which the channel is subjected to a constant field with a gradient formed in some other property (i.e., constant field). Standard deviation of peak width, resolution and peak capacity are important parameters in characterizing equilibrium gradient methods, and general expressions can be obtained from considering both the point of force acting on the analyte and the basic flux equation. Several successful examples, such as density gradient sedimentation, isoelectric focusing and electromobility focusing are discussed. Based on equilibrium gradient methods in the field gradient category, a method to dynamically improve peak capacity is described. An example of such an approach is given using electromobility focusing.     

A Mitochondria-targeted AIEgen Labelled with 18F for Breast Cancer Cell Imaging and Therapy

A lack of efficient diagnostic tools for early and noninvasive diagnosis of breast cancer has restricted the clinical treatment effect. This problem might be addressed by the combination of aggregation-induced emission (AIE) fluorescence imaging and positron emission tomography (PET) with the dual advantages of high resolution and easy operation, and unlimited penetration and high sensitivity. Here, a mitochondria-targeted AIE luminogen (AIEgen) radiolabeled with ¹⁸F was developed through a two-step radiochemical reaction by virtue of a prosthetic group. The obtained ^18/19F-Bz-CP imaging probe was examined by in vitro cell uptake and cell proliferation inhibition in two breast cancer cell lines, showing that the probe can efficiently target and locate in the mitochondria through the analysis of fluorescence imaging and PET simultaneously. Additionally, the probe can induce cancer cell apoptosis with the half maximal inhibitory concentration (IC50) of 4.8 μM for MCF-7 cells and 7.2 μM for T47D cells, indicating its potential application for breast cancer therapy.     

维生素C对生物膜流动性的影响的ESR波谱的研究

本文使用TEMPO和脂肪酸氮氧自由基自旋标记脂质体和正常的与癌变的鼠肝细胞膜,研究了V_c对膜流动性的影响,探讨有关V_c抗肿瘤作用的机理。实验表明:V_c可以影响膜类脂和膜蛋白的运动,提高癌变细胞膜的流动性,并随V_c浓度的增加其作用速度加快,但对正常肝细胞膜流动性则无明显影响。此外,在一定浓度范围内,V_c对正常的与癌变的肝细胞膜的掺入能力有显著差异。     

毛细管区带电泳分析稻瘟病菌诱导水稻叶片蛋白

用毛细管区带电泳分析了受稻瘟病菌侵染的水稻幼苗的叶片细胞蛋白提取物和胞间流液蛋白提取物,用线性聚丙烯酰胺涂渍的毛细管柱来抑制蛋白的吸附。采用数理统计中检验异常值的Ｇｒｕｂｂｓ方法分析结果,与对照实验相比,在叶片细胞蛋白提取物中发现了一种被稻瘟病菌诱导表达的蛋白。     

Suppressing thermal quenching of lead halide perovskite nanocrystals by constructing a wide-bandgap surface layer for achieving thermally stable white light-emitting diodes

Lead halide perovskite nanocrystals as promising ultrapure emitters are outstanding candidates for next-generation light-emitting diodes (LEDs) and display applications, but the thermal quenching behavior of light emission has severely hampered their real-world applications. Here, we report an anion passivation strategy to suppress the emission thermal quenching behavior of CsPbBr₃ perovskite nanocrystals. By treating with specific anions (such as SO₄²⁻, OH⁻, and F⁻ ions), the corresponding wide-bandgap passivation layers, PbSO₄, Pb(OH)₂, and PbF₂, were obtained. They not only repair the surface defects of CsPbBr₃ nanocrystals but also stabilize the phase structure of the inner CsPbBr₃ core by constructing a core–shell like structure. The photoluminescence thermal resistance experiments show that the treated sample could preserve 79% of its original emission intensity up to 373 K, far superior to that (17%) of pristine CsPbBr₃. Based on the thermally stable CsPbBr₃ nanocrystals, we achieved temperature-stable white LED devices with a stable electroluminescence spectrum, color gamut and color coordinates in thermal stress tests (up to 373 K).

Highly thermotolerant CsPbBr₃ perovskite nanocrystals with anti-thermal quenching performance were obtained by constructing wide-bandgap passivation layers coated strongly on the perovskite surface.     

Cyclic RGD–Polyethylene Glycol–Polyethylenimine for Intracranial Glioblastoma‐Targeted Gene Delivery

Even though the blood–brain barrier (BBB) is compromised for angiogenesis, therapeutic agents for glioblastoma multiforme (GBM) are particularly inefficient due to the existence of a blood–tumor barrier (BTB), which hampers tumor accumulation and uptake. Integrin α_vβ₃ is overexpressed on glioblastoma U87 cells and neovasculture, thus making its ligands such as the RGD motif target glioblastoma in vitro and in vivo. In the present work, we have designed a modified polyethylene glycol–polyethylenimine (PEG–PEI) gene carrier by conjugating it with a cyclic RGD sequence, c(RGDyK) (cyclic arginine‐glycine‐aspartic acid‐D ‐tyrosine‐lysine). When complexed with plasmid DNA, this gene carrier, termed RGD–PEG–PEI, formed homogenous nanoparticles with a mean diameter of 73 nm. These nanoparticles had a high binding affinity with U87 cells and facilitated targeted gene delivery against intracranial glioblastoma in vivo, thereby leading to a higher gene transfer efficiency compared to the PEG–PEI gene carrier without RGD decoration. This intracranial glioblastoma‐targeted gene carrier also enhanced the therapeutic efficacy of pORF‐hTRAIL, as evidenced by a significantly prolonged survival of intracranial glioblastoma‐bearing nude mice. Considering the contribution of glioblastoma neovasculature to the BBB under angiogenic conditions, our results demonstrated the therapeutic feasibility of treating a brain tumor through mediation of integrin α_vβ₃, as well as the potential of using RGD–PEG–PEI as a targeted gene carrier in the treatment of intracranial glioblastoma.     

重离子辐照引起磁性隧道结功能失效类型及机理研究

重点研究了磁性隧道结(MTJ)的电学性能受离子注量影响的物理规律。实验首次发现了高能Ta离子辐射损伤导致MTJ电学功能失效的现象,主要失效模式为:高、低电阻态失效,其中79.9%的功能失效为高电阻态失效。计算表明,单个10.9 MeV/u的Ta离子辐照引入的损伤无法导致MTJ宏观电学功能失效。结合理论计算与Monte Carlo模拟分析,MTJ中的绝缘势垒层与铁磁薄膜的损伤是出现高、低电阻态失效的内因。     

Dehydrogenative Homocoupling of Terminal Alkenes on Copper Surfaces: A Route to Dienes

Homocouplings of hydrocarbon groups including alkynyl (sp¹), alkyl (sp³), and aryl (sp²) have recently been investigated on surfaces with the interest of fabricating novel carbon nanostructures/nanomaterials and getting fundamental understanding. Investigated herein is the on‐surface homocoupling of an alkenyl group which is the last elementary unit of hydrocarbons. Through real‐space direct visualization (scanning tunneling microscopy imaging) and density functional theory calculations, the two terminal alkenyl groups were found to couple into a diene moiety on copper surfaces, and is contrary to the common dimerization products of alkenes in solution. Furthermore, detailed DFT‐based transition‐state searches were performed to unravel this new reaction pathway.     

Experimental study on the effect of pyrolysis temperature on the NO emission and conversion during combustion

Journal of Thermal Analysis and Calorimetry - For realizing the coupling pyrolysis of coal and combustion of semi-coke, this paper explored the effect of pyrolysis temperature on the combustion...