全文获取类型
收费全文 | 4973篇 |
免费 | 794篇 |
国内免费 | 559篇 |
专业分类
化学 | 3430篇 |
晶体学 | 46篇 |
力学 | 351篇 |
综合类 | 24篇 |
数学 | 609篇 |
物理学 | 1866篇 |
出版年
2024年 | 25篇 |
2023年 | 103篇 |
2022年 | 167篇 |
2021年 | 201篇 |
2020年 | 200篇 |
2019年 | 193篇 |
2018年 | 188篇 |
2017年 | 138篇 |
2016年 | 281篇 |
2015年 | 234篇 |
2014年 | 269篇 |
2013年 | 381篇 |
2012年 | 481篇 |
2011年 | 461篇 |
2010年 | 309篇 |
2009年 | 289篇 |
2008年 | 309篇 |
2007年 | 254篇 |
2006年 | 243篇 |
2005年 | 212篇 |
2004年 | 186篇 |
2003年 | 158篇 |
2002年 | 133篇 |
2001年 | 113篇 |
2000年 | 94篇 |
1999年 | 100篇 |
1998年 | 73篇 |
1997年 | 74篇 |
1996年 | 74篇 |
1995年 | 60篇 |
1994年 | 45篇 |
1993年 | 45篇 |
1992年 | 27篇 |
1991年 | 38篇 |
1990年 | 35篇 |
1989年 | 26篇 |
1988年 | 12篇 |
1987年 | 12篇 |
1986年 | 14篇 |
1985年 | 18篇 |
1984年 | 9篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1974年 | 2篇 |
1944年 | 4篇 |
1943年 | 1篇 |
1942年 | 3篇 |
1941年 | 1篇 |
1940年 | 1篇 |
排序方式: 共有6326条查询结果,搜索用时 0 毫秒
141.
Li-Wei Wang Songwei Jiang Ying-Hui Yuan Jilong Duan Nian-Dong Mao Zi Hui Renren Bai Tian Xie Xiang-Yang Ye 《Molecules (Basel, Switzerland)》2022,27(8)
As one of the key phosphatidylinositol 3-kinase-related kinases (PIKKs) family members, ataxia telangiectasia and RAD3-related protein kinase (ATR) is crucial in maintaining mammalian cell genomic integrity in DNA damage response (DDR) and repair pathways. Dysregulation of ATR has been found across different cancer types. In recent years, the inhibition of ATR has been proven to be effective in cancer therapy in preclinical and clinical studies. Importantly, tumor-specific alterations such as ATM loss and Cyclin E1 (CCNE1) amplification are more sensitive to ATR inhibition and are being exploited in synthetic lethality (SL) strategy. Besides SL, synergistic anticancer effects involving ATRi have been reported in an increasing number in recent years. This review focuses on the recent advances in different forms of synergistic antitumor effects, summarizes the pharmacological benefits and ongoing clinical trials behind the biological mechanism, and provides perspectives for future challenges and opportunities. The hope is to draw awareness to the community that targeting ATR should have great potential in developing effective anticancer medicines. 相似文献
142.
ML/Y分子筛复合材料的制备,表征及其催化性能研究 总被引:2,自引:2,他引:0
采用沸石合成法制备了ML/Y(M= Fe,Co,Cr;L= 8- quinolinoland salicylic acid (denoted asQx and SArespectively)) 复合材料,并通过XRD、FTIR、ICP、UV- vis 及催化反应等手段对其进行了表征。FTIR和UV- vis 测试结果表明: 合成体系中含有的金属配合物经过水热晶化后封装或固定在分子筛的空腔中。通过X射线衍射原位跟踪Y型分子筛的晶化过程,发现合成体系中含有金属配合物的性质及其量的多少不仅对Y型分子筛的晶化有很大影响,而且使其封装或固定在分子筛中的量也有所差异。另外,以环己烷氧化为探针反应考察了ML/Y的催化性能,结果表明ML/Y的氧化能力来自于所封装或固定的金属配合物,其氧化能力主要取决于配合物中心离子的性质 相似文献
143.
Dr. Hua Bai Can Du Aijuan Zhang Prof. Lei Li 《Angewandte Chemie (International ed. in English)》2013,52(47):12240-12255
A breath figure (BF) is the water droplet array that forms when moisture comes in contact with a cold substrate. This water droplet array has been widely utilized in the past two decades as a versatile soft template for the fabrication of polymeric porous films. Accordingly, the ordered pores on the polymer films formed with such a method are named a breath figure array (BFA).The BF templating technique is undergoing rapid development. Several unconventional BF processes have been established to prepare porous films with unique morphologies or primary materials, and various newly developed functionalization techniques have significantly improved the performance of polymeric films with BFA, leading to novel applications, including templates, biosensors, and separation membranes. These recent achievements will be described in this Minireview. 相似文献
144.
145.
Zhicheng Wang Yaw D. Yeboah Tiejun Bai Kofi B. Bota 《Plasma Chemistry and Plasma Processing》2004,24(3):405-420
Given the operational constraints of aerospace ground equipments (AGE), the nonthermal plasma discharge (NTPD) has been identified as a promising technology for their NOx removal. As part of a program to optimize an NTPD system for this particular application, an investigation of the effect of discharge gap spacing on the electrical and chemical processes that occur in NTPDs was initiated. A number of experiments were performed to examine how the gap spacing affects the NO removal efficiency, discharge characteristics, and chemical reactions in a NTPD device. Gap spacings ranging from 0.8 to 4.0 mm were investigated in this study. An optimum gap spacing for NO removal was observed at approximately 2 mm and, based on the experimental data, a physical explanation for the optimum was developed. The experiments, results and conclusions are discusssed in detail in this paper. 相似文献
146.
147.
148.
采用不可约张量法,分析了KTbP4O12晶体荧光光谱,拟合了五个晶场参量和八个相对论参量,结果与实验吻合。 相似文献
149.
The enantioresolution of zolmitriptan was performed using cyclodextrin (CD)-modified capillary zone electrophoresis (CZE)
with hydroxypropyl-β-CD (HP-β-CD) as the chiral selector. The influence of experimental conditions on the enantioseparation
of zolmitriptan, such as pH, temperature, applied voltage, and concentrations of running electrolyte and CD, was systematically
investigated, obtaining a baseline separation of two enantiomers by the use of a 25 mM sodium dihydrogen phosphate (SDPH)
running electrolyte (pH 2.4) containing 30 mM HP-β-CD at 15 °C. Binding constants for each enantiomer–HP-β-CD pair at different
temperatures, as well as thermodynamic parameters for binding, were calculated. A nonlinear van’t Hoff plot was obtained,
indicating that the thermodynamic parameters of complexation were temperature-dependent for zolmitriptan enantiomers. The
significant contribution of the enthalpy difference to the Gibbs free energy change suggested a stereomeric barrier mechanism
for chiral recognition.
Figure Resolution of zolmitriptan enantiomers was achieved by using CD-modified CZE
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
150.