Suzuki cross‐coupling reactions of aryl chlorides using [Cl2Pd(COD)]/piperazine derivative under microwave conditions

A new strategy to significantly improve the efficiency of Suzuki reactions was achieved under microwave irradiation. [Cl₂Pd(COD)]/piperazine derivative 1 catalyzed aryl chlorides with phenylboronic acid in methanol (50%) affording excellent yields under aerobic conditions. Application of this strategy to the synthesis of liquid crystal material is also described. Copyright © 2011 John Wiley & Sons, Ltd.     

A highly efficient cobalt-catalyzed deuterogenolysis of diboron: Synthesis of deuterated pinacolborane and vinylboronates

Highly efficient hydrogenolysis and deuterogenolysis of diboron compounds have been realized by the use of a cobalt catalyst, affording TON up to 48201. Furthermore, a one-pot two-step procedure comprising sequential deuterogenolysis of diboron and deuteroboration of alkynes under the same cobalt catalyst has been developed for the efficient, atom-economical synthesis of deuterated vinylboronates with high deuterium incorporation and excellent regio- and stereoselectivity.     

高效液相色谱-串联质谱法测定酵素食品中的匹可硫酸钠

建立了高效液相色谱-串联质谱法测定酵素食品中新型减肥类非法添加物匹可硫酸钠的分析方法。针对现有方法不适用的果冻、软糖型样品，开发了新的前处理方法。样品经水提取、聚酰胺净化，使用Thermo Accucore RP-MS色谱柱（100 mm×2.1 mm，2.6 μm），以乙腈-10 mmol/L乙酸铵（15：85，v/v）等度洗脱，流速0.3 mL/min，柱温35℃，多反应监测（MRM）模式下质谱检测，外标法定量。结果表明，匹可硫酸钠在5~500 μg/L范围内线性关系良好，相关系数（r）为0.9999，方法检出限为0.05 mg/kg。匹可硫酸钠在各基质样品中的加标回收率为89.2%~111.8%，相对标准偏差为2.5%~10.4%。按上述方法检测152批次酵素食品，检出阳性样品58批次，检出率为38.2%。该法准确、灵敏，可用于酵素食品中匹可硫酸钠的测定。     

Synthesis of tertiary carbinamines

An efficient synthesis of tertiary carbinamines using a one-pot, three-component reaction employing TMSCl activation of an intermediate imine salt followed by addition of an organometallic is described. An optimized second generation chiral synthesis of select tertiary carbinamines utilizing the Ellman sulfinamine was subsequently developed on a multi-gram scale and is also described.     

Neurocomputing theory and numerical simulation on elasticity

A new finite element analysis principle based on neural networks is propsed. It can realize the finite element analysis in real time. The neural computation of a simple structure was simulated on digital computer, the effect of input parameters on convergent speed and precision was analyzed. Before solving a certain FE problem, the linking weight matrix of the neural net, i.e., the global stiffness matrix of the structure analyzed, must be defined. In this paper, a method which uses the BP net to compute the element stiffness matrix in real time is proposed. The subject is supported by the Natural Science Foundation of China     

A label-free method for identifying electroactive G-quadruplex-binding ligand

Ligands of G-quadruplex have received great attention because of their potential anticancer activity. Here, we designed a label-free electrochemical method to identify electrochemically active molecules that stabilize G-quadruplexes in homogeneous medium. Daunorubicin (DNR) was used as model drug. In the presence of GDNA, the voltammetry of DNR changed. The binding constant (β) and binding-site number (m) of GDNA – mDNR are simultaneously obtained from dependence of the current on the amount of added GDNA in voltammetry, concluding that β = (2.37 ± 2.25) × 10⁷ M^? 1and m was near 1, respectively. Control experiment was performed, indicating that this method can specific identify G-quadruplex-binding ligand. The interaction mechanism of DNR with GDNA was also investigated by circular dichroism (CD). The result demonstrated that it is a simple and selective method for identification electroactive ligand with potential anticancer activity.     

About the special topic of mechanics and biomimetics of biomaterials and animal locomotion

Scientists have increasingly been turning their attentions to searching for inspirations from the splendid living world in order to solve various challenging problems of technologically importance. Rapid advances in observation techniques and computational ability will make it a reality to understand, at different time and space scales, the functions,