A Unique Indolo‐[1,7]naphthyridine Alkaloid from Incarvillea mairei var. grandiflora (Wehrh.) Grierson

A novel alkaloid with a unique indolo‐[1,7]naphthyridine nucleus, incargranine B, was isolated from the whole plant of Incarvillea mairei var. grandiflora (Wehrh.) Grierson . Its structure was determined by means of spectroscopic methods.     

A generalized quasi-boundary value method for the backward semi-linear time-fractional heat problem in a cylinder

We are concerned with a backward problem associated with a semi-linear time-fractional heat equation in an axis-symmetric cylinder, which arises from the modeling of the blast furnace steelmaking in metallurgy. Under some assumptions, the existence and uniqueness of the solution to the semi-linear problem is first established. The ill-posedness of the backward problem is then established, and we obtain the error estimates by a generalized quasi-boundary value regularization method. Finally, the numerical experiment is presented to demonstrate the effectiveness of the proposed method.     

Copper(I) halides: A versatile family in coordination chemistry and crystal engineering

The copper(I) halide aggregates represent a versatile family in coordination chemistry and crystal engineering. First discovered a century ago these species have been intensively investigated in the last three decades because of their structural and luminescent uniqueness. This account reviews their research history and frontier (Section 1), synthetic routes (Section 2) and structural diversity (Section 3), and also offers personal perspectives (Section 4) on the growth, property and application of the copper(I) halide aggregates in coordination polymers.     

Aliphatic peptidyl hydroperoxides as a source of secondary oxidation in hydroxyl radical protein footprinting

Hydroxyl radical footprinting is a technique for studying protein structure and binding that entails oxidizing a protein system of interest with diffusing hydroxyl radicals, and then measuring the amount of oxidation of each amino acid. One important issue in hydroxyl radical footprinting is limiting amino acid oxidation by secondary oxidants to prevent uncontrolled oxidation, which can cause amino acids to appear more solvent accessible than they really are. Previous work suggested that hydrogen peroxide was the major secondary oxidant of concern in hydroxyl radical footprinting experiments; however, even after elimination of all hydrogen peroxide, some secondary oxidation was still detected. Evidence is presented for the formation of peptidyl hydroperoxides as the most abundant product upon oxidation of aliphatic amino acids. Both reverse phase liquid chromatography and catalase treatment were shown to be ineffective at eliminating peptidyl hydroperoxides. The ability of these peptidyl hydroperoxides to directly oxidize methionine is demonstrated, suggesting the value of methionine amide as an in situ protectant. Hydroxyl radical footprinting protocols require the use of an organic sulfide or similar peroxide scavenger in addition to removal of hydrogen peroxide to successfully eradicate all secondary oxidizing species and prevent uncontrolled oxidation of sulfur-containing residues.     

The rôle of countercurrent chromatography in the fractionation of complex mixtures

The biologically active pricipals in nature are frequently present as only a few parts per million of complex mixtures of non-volatile components and often have limited stability. Their isolation often requires the application of all available techniques, such as adsorption chromatography, ion exchange procedures, size exclusion techniques, and solvent partition methods consistent with their physical properties and stability. The process of countercurret chromatography is essentially liquid-liquid chromatography in which the stationary liquid bed is retained in the column by a force field rather than by a solid supporting matrix. Adsorption effects are thereby eliminated. The technique is particularly advantageous in the preparative separation of milligram to gram quantities of polar and labile organic compounds and bio-particulate materials such as cells and cell fragments. Virtually any twophase solvent system, either aqueous or non-aqueous may be employed. Countercurrent chromatography (CCC) provides a convenlent alternative to adsorption chromatography for fractionation of natural products or other complex mixtures. In some cases, this high resolution method offers advantages with regard to the avoidance of contamination from solid adsorbents, versatility, and relatively inexpensive operation. The article covers some of the applications, selection of solvents, and advantages of CCC.     

Vinyl monomers bearing chromophore moieties and their polymers. VIII. synthesis and fluorescence behavior of a vinyloxy monomer having an electron‐accepting chromophore moiety,p‐((vinyloxy)methyl)benzonitrile,and its polymers

A vinyloxy monomer having an electron‐accepting chromophore moiety, p‐((vinyloxy)methyl)benzonitrile (VOMBN), was synthesized by reaction of p‐(hydroxymethyl)benzonitrile with ethyl vinyl ether (EVE) in the presence of mercuric acetate. VOMBN can easily be cationically homopolymerized and copolymerized with EVE by using Lewis acids such as boron trifluoride etherate (BF₃ · OEt₂) as a catalyst and radically copolymerized with maleic anhydride (MAn) using AIBN as an initiator. The fluorescence behaviors of VOMBN, its copolymer P(VOMBN‐co‐MAn), and its saturated model compound p‐(ethoxymethyl)benzonitrile (EOMBN) were investigated in acetonitrile. It has been found that the fluorescence intensity of VOMBN is much lower than its copolymer and EOMBN at the same chromophore concentration. A fluorescence “structural self‐quenching effect” (SSQE) is also observed for VOMBN as we have reported previously [Li, F. M.; Chen, S. J.; Li, Z. C.; Qiu, J. J Polym Sci Polym Chem 1996, 34, 1881]. This phenomenon has been attributed to the inter‐ and intramolecular charge transfer interaction between the electron‐accepting cyanophenyl chromophore and the electron‐donating vinyloxy group in the same molecule. The dependence of the fluorescence intensity of VOMBN on solvents of different viscosities is evidence that the SSQE of VOMBN mainly occurs intramolecularly. The fluorescence of EOMBN and P(VOMBN‐co‐MAn) was quenched by a series of electron‐rich vinyloxy compounds which do not have chromophore moieties, such as dihydrofuran (2H‐furan), dihydropyran (2H‐pyran), furan, and EVE. It is observed that the higher the electron‐donating ability of the quenchers, the greater the quenching efficiency. P(VOMBN) and the random copolymers of VOMBN with EVE show broader fluorescence spectra as compared to the alternating copolymer P(VOMBN‐co‐MAn). This indicates that there is a mutual interaction between the adjacent cyanophenyl groups in P(VOMBN) and P(VOMBN‐co‐EVE), whereas such an interaction does not exist for P(VOMBN‐co‐MAn) in which the cyanophenyl groups are isolated by the rigid succinic anhydride rings. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 179–187, 1999     

Second-order effect of an elastic circular shaft during torsion

In this paper we deal with the second-order effect of an elastic circular shaft duringtorsion.The analysis is based on the method of co-moving coordinates and the strain-rotation decomposition theorem in continuum mechanics.By using asymptotic expansionmethods,we comfirm that the effect of axial elongation and distortion of plane cross-section exists in an elastic circular shaft during large torsion and give the expressions ofthe axial force and the torque.     

弹性圆杆扭转的二阶效应

本文基于拖带坐标方法和S-R分解定理[1]分析了弹性圆杆扭转的二阶效应.应用渐近方法,证明了弹性圆杆扭转伸长效应的存在,并导出轴向力、扭矩的表达式.     

Two-Dimensional Reproducing Kernel and Surface Interpolation

One-dimensional polynomial interpolation does not guarantee the convergency and the stability during numerical computation. For two (or multi)-dimensional interpolation, difficulties are much more raising. There are many fundamental problems, which are left open. In this paper,we begin with the discussion of reproducing kernel in two variables. With its help we deduce a two-dimensional interpolation formula. According to this formula, the process of interpolation will converge uniformly, whenever the knot system is thickened in finitely. We have also proven that the error function will decrease monotonically in the norm when the number of knot points is increased. In our formula, knot points may be chosen arbitrarily without any request of regularity about their arrangement. We also do not impose any restriction on the number of knot points. For the case of multi-dimensional interpolation, these features may be important and essential.     

On the Inclination of Planetary Orbits

Assuming that planets were formed in the equatorial plane of the Sun and that there was a small perturbation at the start, it is shown that relativistic effects could lead to the planetary orbit tilting observed. On the baais of this analysis, a prediction is made for the velocity of the planet Mercury out of its orbital 'plane'. This prediction is a lower limit. Further, this explanation may possibly provide a method for determining the solar angular momentum.