Reactions of 1-cyanazoles with carbohydrazides

(N″-acyl)azole-1-carbohydrazonamides were synthesized by the reaction of 1-cyanazoles with carbohydrazides. The yield of the final reaction products was shown to depend on the structure of the hydrocarbon radical in the carbohydrazide.     

Quantum chemical study of the influence of electronic factors on the thermodynamic characteristics of 1,3-dipolar cycloaddition of benzonitrile oxides and benzonitrile sulfides to weakly activated alkenes

Russian Chemical Bulletin - The main thermodynamic characteristics of the reactions of para-substituted benzonitrile oxides and benzonitrile sulfides with propylene were calculated by the density...     

Azolyl-substituted 1,2,3-triazoles

Huisgen reaction of (E)-1,5-diarylpent-2-en-4-yn-1-ones and (E)-1,5-diarylpent-1-en-4-yn-3-ones afforded 1-aryl-3-(5-aryl-1H-1,2,3-triazol-4-yl)prop-2-en-1-ones and 3-aryl-1-(5-aryl-1H-1,2,3-triazol-4-yl)-prop-2-en-1-ones, respectively. (E)-1-Aryl-3-(5-phenyl-1H-1,2,3-triazol-4-yl)prop-2-en-1-ones reacted with hydrazine hydrate and phenylhydrazine to give 72–93% of 4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-5-phenyl-1H-1,2,3-triazoles which underwent dehydrogenation on heating in boiling acetic acid with formation of the corresponding pyrazole derivatives. The molecular structures of (E)-3-phenyl-1-(5-phenyl-1H-1,2,3-triazol-4-yl)prop-2-en-1-one and 4-[3-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl]-5-phenyl-1H-1,2,3-triazole were studied by X-ray analysis. 4-(3-Aryl-4,5-dihydro-1H-pyrazol-5-yl)-5-phenyl-1H-1,2,3-triazoles showed toxicity against Daphnia magna.     

Aminoacyl derivatives of nucleosides,nucleotides, and polynucleotides

Conclusions A method for the synthesis of 3(2)-O-aminoacylnucleoside 5-di- and triphosphates has been developed which is based on the condensation of the imidazolides of N-tert-butoxycarbonylamino acids with nucleoside di-and triphosphates and subsequent removal of the tert-butoxycarbonyl protection by treatment with hydrogen chloride in absolute ether.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1084–1087, May, 1968.     

Aminoacyl derivatives of nucleosides,nucleotides, and polynucleotides

Russian Chemical Bulletin -     

Synthesis of (−)-(4R,5R)- and (+)-(4S,5S)-1-alkyl-4-(4′-nitrophenyl)-1-azonium-3,7-dioxabicyclo[3.3.0]octane halides

A preparative method has been proposed for the synthesis of bicyclic quaternary ammonium salts via sequential treatment of (–)-(1R,2R)- and (+)-(1S,2S)-1-(4-nitrophenyl)-2-amino-1,3-propanediol with paraform followed by an alkyl halide.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1394–1395, October, 1990.