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Ramesh Adepu Marumudi Kanakaraju Nagula Chandramouli Purushotham P. Reddy Gangavaram V.M. Sharma Akella V.S. Sarma Ajit C. Kunwar 《Tetrahedron》2018,74(42):6095-6106
The present study describes the synthesis of new C-linked carbo-β-amino acids [β-Caa(1,2-ddx)], with a 1,2-dideoxy D-xylo furanoside side chain (a tetrahydro furan derivative). The stereochemistry at the newly created amine centers was determined by modified Mosher method. The (S)-β-Caa(1,2-ddx) prepared from d-mannose diacetonide were utilized for the synthesis of 1:1 α/β-peptides with L-Ala. The conformational analysis (NMR, MD and CD) revealed the presence of 11/9-helix, helix induced helix-turn (HT) and helix-turn-helix (HTH) in these peptides. These side chains with tetrahydrofuran ring facilitated the formation of robust helix, unlike some other side chains from earlier studies. 相似文献
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Baggu Chinnababu Sudina Purushotham Reddy Kunuru Venkatesham Dasireddi Chandra Rao Yenamandra Venkateswarlu 《Helvetica chimica acta》2014,97(5):613-618
A simple and highly efficient synthetic route has been developed for synthesis of 1‐(4‐hydroxyphenyl)nonadecane‐3,5‐diol ( 1 ). The two stereogenic centers were generated by employing proline asymmetric α‐hydroxylation (MacMillan α‐hydroxylation), Jacobsen's hydrolytic kinetic resolution (HKR), and, finally, Yamaguchi oxirane opening as key steps (Scheme 2). 相似文献