Glycosylated star-shaped conjugated oligomers for targeted two-photon fluorescence imaging

A glucopyranose functionalized star-shaped oligomer, N-tris{4,4',4'-[(1E)-2-(2-{(E)-2-[4-(benzo[d]thiazol-2-yl)phenyl]vinyl}-9,9-bis(6-2-amido-2-deoxy-1-thio-β-D-glucopyranose-hexyl)-9H-fluoren-7-yl)vinyl]phenyl}phenylamine (TVFVBN-S-NH(2)), is synthesized for two-photon fluorescence imaging. In water, TVFVBN-S-NH(2) self-assembles into nanoparticles with an average diameter of ～49?nm and shows a fluorescence quantum yield of 0.21. Two-photon fluorescence measurements reveal that TVFVBN-S-NH(2) has a two-photon absorption cross-section of ～1100 GM at 780?nm in water. The active amine group on the glucopyranose moiety allows further functionalization of TVFVBN-S-NH(2) with folic acid to yield TVFVBN-S-NH(2) FA with similar optical and physical properties as those for TVFVBN-S-NH(2). Cellular imaging studies reveal that TVFVBN-S-NH(2) FA has increased uptake by MCF-7 cells relative to that for TVFVBN-S-NH(2), due to specific interactions between folic acid and folate receptors on the MCF-7 cell membrane. This study demonstrates the effectiveness of glycosylation as a molecular engineering strategy to yield water-soluble materials with a large two-photon absorption (TPA) cross-section for targeted cancer-cell imaging.     

Two Complexes from One Reaction of Nickel(II) Ion with a New Schiff Base Ligand

Abstract  

A new Schiff base ligand of 1-(2, 6-dichlorobenzylidene)-4-phenylthiosemicarbazide(C₁₄H₁₁Cl₂N₃S) has been synthesized, which crystallizes in monoclinic, space group C2/c with a = 18.551(7) ?, b = 6.963(3) ?, c = 23.185(9) ? and β = 93.122(6)o. The reaction of this ligand with NiAc₂·4H₂O gives two different Ni(II) complexes, one is general traditional mononuclear and another is unexpected trinuclear, where another quadridentate ligand of 1-(amino-N-phenylmethanethio)-4-phenyl-thiosemicarbazide(C₁₄H₁₄N₄S₂) is found. The mononuclear complex (C₃₂H₂₆Cl₄N₈NiS₂) crystallizes in triclinic, space group P−1 with a = 11.071(2) ?, b = 11.157(2) ?, c = 15.302(3) ?, α = 76.214(2)o, β = 87.902(2)o and γ = 79.586(3)o. The trinuclear complex (C₆₀H₅₀Cl₄N₁₆Ni₃S₆) crystallizes in orthorhombic, space group Pbcn with a = 19.673(3) ?, b = 16.094(3) ? and c = 20.465(4) ?. In above three compounds, there are some hydrogen bonds which help to construct the three dimensional net works and stabilize the molecular structures.     

High Flattened Comb Filter with Precise Channel Spacing Based on Linearly Chirped Fiber Bragg Grating and Phase Compensation

Abstract

A novel approach to implement high flattened comb filters with precise channel spacing based on DC phase compensation is proposed. Channel wavelength error and peak reflectivity variation are discussed and calculated. A phase compensation method by simply changing the DC refractive index is proposed. Fiber Bragg gratings with different DC phase shifts are fabricated, which indicates that an arbitrary DC phase shift can be introduced precisely. A high flattened comb filter with precise 50-GHz channel spacing is realized with the help of a micrometer-precision translation stage. Then the peak reflectivity variation with and without phase compensation for different chirp coefficients is researched.     

Study of n-γ discrimination for 0.4-1 MeV neutrons using the zero-crossing method with a BC501A liquid scintillation detector

An experimental system aimed at n-γ discrimination using the zero-crossing method with a φ3’’×2’’ BC501A liquid scintillation detector was established and tested with an Am-Be neutron source. Two-dimensional plots of energy versus zero-crossing time were obtained. The quality of n-γ discrimination was checked by the figure-of-merit (FOM), the neutron peak-to-valley ratio, and the proportion of leaked neutrons over all neutron events. The performance of n-γ discrimination in terms of FOM was compared with previous work done by other groups. The n-γ discrimination in four different energy regions with an interval of 0.1 MeV between 0.3 MeV and 0.7 MeV was studied, and the results indicate that the n-γ discrimination threshold can go down to 0.4 MeV.     

Two-dimensional residual charge density distribution measurement of surface leader

The charge density distribution of the surface leader has never been measured before. Because the surface leader usually covers a long distance, and the surface potential caused by leader discharge is usually very high, this creates difficulties in measuring the potential distribution of the surface leader. In this paper, with a feedback type electrostatic probe based on a field-nullify technique, a charge density distribution scanning system is developed. A two-layer structure pipe is designed to lower the surface potential after discharge. In this way, the surface potential distribution caused by the residual charge of the leader discharge under the application voltage as high as to 40 kV can be measured. The surface charge density distribution including the leader and streamer is perfectly measured, which is in good agreement with the photograph.     

Robustness analysis of static routing on networks

Robustness is one of the crucial properties that needs to be considered in the design of routing strategies on networks. We study the robustness of three typical routing strategies, which are the SP (shortest path), EP (efficient path), and OP (optimal path) strategies, by simulating several different kinds of attacks including random attacks, target attacks and cascading failures on scale-free networks. Results of the average path length, betweenness centrality, network capacity, etc., demonstrate that the EP strategy is more robust than the other two, and the OP strategy is more reliable than the SP strategy in general. However, on the power-grid network, the OP strategy is more resistant against cascading failures than the EP and SP strategies.     

Extremely large bandwidth and ultralow-dispersion slow light in photonic crystal waveguides with magnetically controllability

A line-defect waveguide within a two-dimensional magnetic-fluid-based photonic crystal with 45^o-rotated square lattice is presented to have excellent slow light properties. The bandwidth centered at $ \lambda_{0} $  = 1,550 nm of our designed W1 waveguide is around 66 nm, which is very large than that of the conventional W1 waveguide as well as the corresponding optimized structures based on photonic crystal with triangular lattice. The obtained group velocity dispersion $ \beta_{2} $ within the bandwidth is ultralow and varies from ?1,191 $ a/(2\pi c^{2} ) $ to 855 $ a/(2\pi c^{2} ) $ (a and c are the period of the lattice and the light speed in vacuum, respectively). Simultaneously, the normalized delay-bandwidth product is relatively large and almost invariant with magnetic field strength. It is indicated that using magnetic fluid as one of the constitutive materials of the photonic crystal structures can enable the magnetically fine tunability of the slow light in online mode. The concept and results of this work may give a guideline for studying and realizing tunable slow light based on the external-stimulus-responsive materials.     

高功率、低量子亏损同带抽运掺镱光纤放大器

开展了基于同带抽运的高功率、低量子亏损的掺镱光纤放大器实验研究. 搭建了一台输出功率为21 W的1018 nm短波 长掺镱光纤激光器, 并利用其对双包层掺镱光纤进行同带抽运, 获得18.6 W的1080 nm波段激光输出, 光-光转换效率高达90.86%. 关键词： 光纤放大器 同带抽运 双包层光纤 转换效率     

光纤非相干合成光束在湍流大气中的传输实验研究

进行了六路100 W量级光纤非相干合成光束在实际大气湍流中的传输实验,将六路光斑直径为9 mm的单模光纤光束分别扩束,扩束后的光斑直径为90 mm。基于倾斜镜的合束系统来控制各路光束的指向,在不同强度的湍流条件中,通过主镜口径为440 mm的发射系统水平聚焦传输至470 m处。倾斜控制系统闭环工作时,一倍衍射极限内的桶中功率占目标处总功率的比值是开环工作时的1.7倍左右,随着大气湍流的强度变弱,此比值变大。     

再发射技术测量SGⅡ黑腔靶早期对称性

利用再发射技术能够有效测量早期辐射驱动对称性。2011年在神光Ⅱ激光装置上,采用Bi替代靶,通过改变靶丸的支撑方式和优化探测器配置,利用分幅相机获得较高信噪比的Bi球表面再发射图像。利用实验结果获得了入射流不对称性P2分量随时间的变化,对比两种腔长的黑腔,P2分量随时间的变化存在明显差别。两种腔P2分量随时间的变化趋势与采用视角因子模拟的结果基本一致。