In the present scenario, the application of reactive agents in industries plays a vital role in the production processes of various materials such as paper production, drawing of wires, etc. Keeping in mind it is necessary to discuss the application of heterogeneous and homogeneous chemical reactions in a micropolar nanofluid flow over a stretching surface where the sheet is considered to be nonlinear. In addition to that, the inclusion of heat generation/absorption in the energy equation of an electrically conducting fluid also affects the fluid flow phenomena. In the present analysis, the Maxwell model thermal conductive is considered with Fe3O4, CuO nanoparticles, and water is treated as base fluid. It is very much transparent that the nonlinear dimensional form of the PDEs gets transformed into ODEs and a semi-analytical approach is employed, i.e., Adomian decomposition method (ADM) for those transformed ODEs. The computation for several characterizing parameters is obtained using the mathematical package MAPLE and these are displayed via graphs and tables. An excellent concurrence with the earlier established result is found which validates the result with the current methodology.
In this study, the bark of an important medicinal plant, Indigofera aspalathoides is utilized as a bioreductant for the synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). The formation of nanoparticles was monitored, and the reaction parameters were optimized by UV–Vis spectroscopy. The attachment of biocomponents as stabilizer was proved employing Fourier‐transform infrared (FT‐IR) studies. Through transmission electron microscopy (TEM), the morphology was found to be predominantly spherical and a mixture of triangle and hexagon in the case of AgNPs and AuNPs, respectively. The crystallite size of AgNPs and AuNPs was affirmed through X‐ray diffraction (XRD) studies using Sherrer formula as 22.03 and 47.70 nm, respectively. DPPH method was adopted to analyse the free‐radical quenching ability, and the AgNPs, AuNPs and extract showed inhibition of 76%, 89% and 59% at a concentration of 200 μg ml?1, and the corresponding IC50 values were 86.49, 55.20 and 149.19 μg ml?1. The binding of nanoparticles to calf‐thymus DNA (CT‐DNA) was through groove and the high binding constants (8.49 × 106 M?1 and 2.34 × 107 M?1 for AgNPs and AuNPs) point out the potential of these nanoparticles as curative drugs. The MTT assay showed that AgNPs were 100% toxic, and the low IC50 value suggests that this can be used in the medicinal field as a safe drug. 相似文献
A novel furan based scaffold 5-hydroxymethylfurfural has been identified for the generation of combinatorial libraries using template directed approach on solid phase. This scaffold has been utilized to afford furan-based bi-heterocyclic structures with extensive chemical diversity using cycloaddition, multicomponent and cyclization reactions. 相似文献
NiO/ZnO composite derived metal-organic framework (MOF) is used as to modify carbon felt (CF) via a conventional solid-state reaction followed by ultrasonication. The prepared electrode material is used in zinc-hybrid redox flow batteries (RFBs) due to their high redox activity of Zn2+/Zn. The electrochemical performance of composite modified CF and pre-treated CF was studied by cyclic voltammetry (CV) in 0.5 M aqueous zinc chloride with 5 M potassium hydroxide solutions showed clear confirmation for enhanced electrocatalytic activity. The unique porous structure of NiO/ZnO-derived MOF with increased surface area improves the battery behavior significantlyThe peak current ratio for the as-prepared material is about 3 times higher than that of the pre-treated CF due to more active sites. Zinc-based RFB with modified CF electrode exhibited better electrochemical performance with voltage efficiency (VE, 88 %), which is higher than true redox flow batteries. 相似文献
Results from replica-exchange and regular room temperature molecular dynamics simulations of the Alzheimer's beta amyloid (Abeta(1-39)) monomer in an implicit solvent are reported. Our data indicate that at room temperature, the monomer assumes random-coil and soluble conformations. No beta content is observed which therefore seems to be a product of oligomerization and aggregation of monomers. 相似文献
β-sitosterol (SIT), the most abundant bioactive component of vegetable oil and other plants, is a highly potent antidiabetic drug. Our previous studies show that SIT controls hyperglycemia and insulin resistance by activating insulin receptor and glucose transporter 4 (GLUT-4) in the adipocytes of obesity induced type 2 diabetic rats. The current research was undertaken to investigate if SIT could also exert its antidiabetic effects by circumventing adipocyte induced inflammation, a key driving factor for insulin resistance in obese individuals. Effective dose of SIT (20 mg/kg b.wt) was administered orally for 30 days to high fat diet and sucrose induced type-2 diabetic rats. Metformin, the conventionally used antidiabetic drug was used as a positive control. Interestingly, SIT treatment restores the elevated serum levels of proinflammatory cytokines including leptin, resistin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) to normalcy and increases anti-inflammatory adipocytokines including adiponectin in type 2 diabetic rats. Furthermore, SIT decreases sterol regulatory element binding protein-1c (SREBP-1c) and enhances Peroxisome Proliferator–activated receptor-γ (PPAR-γ) gene expression in adipocytes of diabetic rats. The gene and protein expression of c-Jun-N-terminal kinase-1 (JNK1), inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) and nuclear factor kappa B (NF-κB) were also significantly attenuated in SIT treated groups. More importantly, SIT acts very effectively as metformin to circumvent inflammation and insulin resistance in diabetic rats. Our results clearly show that SIT inhibits obesity induced insulin resistance by ameliorating the inflammatory events in the adipose tissue through the downregulation of IKKβ/NF-κB and c-Jun-N-terminal kinase (JNK) signaling pathway. 相似文献
Molecular Diversity - Mycobacteria have shown enormous resilience to survive and persist by remodeling and altering metabolic requirements. Under stringent conditions or exposure to drugs,... 相似文献
Two simple phthalimide–hydrazone probes with nitro groups were synthesised and characterised by NMR, FT-IR, HR-MS and single crystal X-ray crystallography. The synthesised receptors were evaluated for application in anion sensing. The receptors displayed strong, sensitive and selective colouration in the presence of cyanide ions by forming a stable complex with cyanide ion. The use of variable nitro groups helped in the elucidation of the mechanism of the complex formation. The 1H NMR spectroscopy was used to support the mechanism of the complex formation. DFT methods were used to understand the stability of the complex with respect to the reactant. The absorbance data were also compared with the TD-DFT calculated excitation parameters. The experimental results were found to correlate well with the theoretical data. 相似文献
The roots of Dalbergia horrida yielded two new isoflavanones, Dalhorridin (I) - 5,5'-dihydroxy-3',4'-methylenedioxy-5'-prenyl-6',6'-dimethyl-dihydropyrano(2',3' : 7,8)-isoflavanone and Dalhorridinin (II) - 5,7,5'-trihydroxy-3',4'-methylenedioxy-8-[5-methyl-2-(2-hydroxyisopropyl)-1,4-hexadienyl]isoflavanone along with two known isoflavones, Dalspinin and Dalspinosin. Preliminary biological screening of the enriched extract revealed that it showed analgesic, anti-inflammatory, CNS depressant and mild anti-bacterial properties. 相似文献