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11.
This paper discusses recent trends in the field of reverse engineering, particularly those highlighted at the Second Working
Conference on Reverse Engineering, held in July 1995. The trends observed include increased orientation toward tasks, grounding
in complex real-world applications, guidance from empirical study, analysis of non-code sources, and increased formalization.
The paper also summarizes open research issues and provides pointers to future events and sources of information in this area. 相似文献
12.
Kochocki JA Allison WW Alner GJ Ambats I Ayres DS Balka LJ Barr GD Barrett WL Benjamin D Border P Brooks CB Cobb JH Cockerill DJ Coover K Courant H Dahlin B DasGupta U Dawson JW Edwards VW Fields TH Kirby-Gallagher LM Garcia-Garcia C Giles RH Goodman MC Heller K Heppelman S Hill N Hoftiezer JH Jankowski DJ Johns K Joyce T Kafka T Litchfield PJ Lopez FV Lowe M Mann WA Marshak ML May EN McMaster L Milburn RH Miller W Napier A Oliver WP Pearce GF Perkins DH Peterson EA Price LE Roback D Rosen DB 《Physical review D: Particles and fields》1990,42(9):2967-2973
13.
Abachi S Derrick M Kooijman P Musgrave B Price LE Repond J Sugano K Blockus D Brabson B Brom J Jung C Ogren H Rust DR Akerlof C Chapman J Errede D Ken MT Meyer DI Neal H Nitz D Thun R Tschirhart R Baringer P Bylsma BG DeBonte R Koltick D Low EH McIlwain RL Miller DH Ng CR Shibata EI 《Physical review D: Particles and fields》1989,40(3):902-905
14.
Phanstiel O IV Price HL Wang L Juusola J Kline M Shah SM 《The Journal of organic chemistry》2000,65(18):5590-5599
An efficient five-step synthetic method was developed to access a homologous series of spermidine-acridine and spermidine-anthracene conjugates. The derivatives were comprised of a spermidine fragment covalently tethered at its N4 position to either an acridine or anthracene nucleus via an aliphatic chain (e.g., spermidine-[aliphatic tether]-acridine). The distance separating the spermidine and aromatic nucleus was altered by using different tethers comprised of four or five methylene units, respectively. These ligands (2-5) were shown to inhibit human DNA topoisomerase-II (TOPO-II) activity at 10 microM. Enzymatic activity was assessed as the ability to unknot (decatenate) and cleave kinetoplast DNA (kDNA). Polyamine conjugation did not disrupt the ability of the acridine-spermidine conjugates 2 and 3 to inhibit TOPO-II activity as compared with the 9-aminoacridine and 9-(N-butyl)aminoacridine controls (at 10 microM). In general, the acridine derivatives (2 and 3) showed higher TOPO-II inhibitory activity than their anthracene counterparts (4 and 5). However, this trend was reversed in a whole cell assay with L1210 (murine leukemia) cells, wherein the anthracene analogues were more potent than their acridine counterparts. In this regard the qualitative enzyme-based assay did not predict the trends in the corresponding IC(50) values. Within either series insertion of an additional methylene unit did not significantly alter activity. While the appended spermidine unit did not disrupt TOPO II inhibition by the tethered DNA intercalator, it did provide an alternative mode of entry into the cell as demonstrated by spermidine protection assays. These results were compared with a spermine-intercalator analogue. Of all the conjugates tested the N(4)-(4-(9-aminoacridinyl)butyl)spermine hexahydrochloride (conjugate 16)resulted in the highest degree of L1210 cell rescue upon cotreatment of the cells with exogenous spermidine. It was concluded that the monoalkylated spermine motif present in 16 holds promise as a better vector than its N4 monoalkylated spermidine counterpart. 相似文献
15.
16.
17.
Price WJ Kuo PK Lee TR Colorado R Ying ZC Liu GY 《Langmuir : the ACS journal of surfaces and colloids》2005,21(18):8422-8428
Nanostructures of self-assembled monolayers (SAMs) are designed and produced using coadsorption and nanografting techniques. Because the structures of these artificially engineered domains are predesigned and well-characterized, a systematic investigation is possible to study the mechanical responses to force modulation under atomic force microscope tips. Force modulation imaging reveals characteristic contrast sensitivity to changes in molecular-level packing, molecule chain lengths, domain boundaries, and surface chemical functionalities in SAMs. By means of actively tuning the driving frequency, the resonances at the tip-surface contact are selectively activated. Therefore, specific surface features, such as the edges of the domains and nanostructures or desired chemical functionalities, can be selectively enhanced in the amplitude images. These observations provide a new and active approach in materials characterization and the study of nanotribology using atomic force microscopy. 相似文献
18.
Abachi S Akerlof C Baringer P Blockus D Brabson B Brom J Bylsma BG Chapman J Cork B DeBonte R Derrick M Errede D Gan KK Jung C Ken MT Koltick D Kooijman P Loeffler FJ Loos JS Low EH McIlwain RL Meyer DI Miller DH Musgrave B Neal H Ng CR Nitz D Ogren H Paik HW Price LE Rangan LK Repond J Rust DR Shibata EI Sugano K Thun R Tschirhart R 《Physical review letters》1987,59(22):2519-2522
19.
20.
Abachi S Baringer P Bylsma BG DeBonte R Koltick D Loeffler FJ Low EH McIlwain RL Miller DH Ng CR Rangan LK Shibata EI Derrick M Gan KK Kooijman P Loos JS Musgrave B Price LE Repond J Sugano K Weiss JM Wood DE Blockus D Brabson B Brom J Jung C Ogren H Rust DR Akerlof C Chapman J Errede D Kesten P Meyer DI Nitz D Seidl AA Thun R Willutzky M Cork B 《Physical review letters》1986,57(16):1990-1993