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71.
An efficient synthetic route for 2,3-dihydroquinazolin-4(1H)-ones using 2-morpholinoethanesulfonic acid as a potential and new organocatalyst is described. The developed synthetic protocol represents a novel and very simple route for the preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. In addition, microwave irradiation technique is successfully implemented for carrying out the reactions in shorter reaction times. 相似文献
72.
Pravin S. Bhale Babasaheb P. Bandgar Sakharam B. Dongare Sadanand N. Shringare Dnyaneshwar M. Sirsat 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):843-849
AbstractKetene dithioacetal mediated chemo- and regioselective synthesis of a series of novel 1,3,4,5-tetrasubstituted pyrazole derivatives (4a-l) integrated with a bioactive indole nucleus was achieved by reacting substituted 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis-(methylthio)-acrylonitrile (2) and substituted phenyl hydrazine hydrochloride (3) in the presence of a catalytic amount of anhydrous K2CO3 under reflux conditions. The structures were ascertained by 1H NMR, NOESY, 13C NMR, FT-IR, and HRMS data. In vitro cytotoxicity evaluation of the synthesized compounds against MCF 7 (breast carcinoma) and normal Vero (monkey kidney) cell lines revealed that the compound 5-(5-Bromo-1-methyl-1H-indol-3-yl)-1-(4-cyano-phenyl)-3-methylsulfanyl-1H-pyrazole-4-carbonitrile (4k) showed significant cytotoxicity against MCF 7 (GI50 = 15.6 µM) with low cytotoxicity against normal Vero cell line. Most of the synthesized compounds were also found to possess excellent anti-inflammatory and antioxidant (DPPH, NO, H2O2 and SOR) potential. 相似文献
73.
Experimental investigation and simulation of hollow fiber membrane process for SF6 recovery from GIS
In this present study, polyethersulfone hollow fiber membrane was used to recover sulfur hexafluoride (SF6) from gas‐insulated switchgear (GIS). SF6, N2 pure gas and mixed gas (12.5 vol.% of SF6) experiment was initiated to observe permeation behavior according to temperature and pressure difference and retentate flow rate. Scanning electron microscopy was used to investigate the morphological characteristics and the structure of asymmetric hollow fibers. The permeation rates of SF6 and N2 were measured by the variable pressure method. As a result, permeance of N2 was 9.5–16.3 GPU, and selectivity of N2/SF6 was 10.5–13.3. Moreover, the concentration of SF6 in the retentate stream reached to 99.2% by the control of the operating condition. Based on the experimental results, tree‐stage membrane process was designed using simulation program. As a result, demanded membrane area reduced about 74% according to operating condition difference. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
74.
We study, experimentally as well as theoretically, the spatial coherence function and the Wigner distribution function for one-dimensional projections of optical vortices of different orders. The information entropy derived from the spatial coherence functions has been used to quantify the information content of the vortices and compared with those obtained for the Gaussian beam. The experimental results verify the theoretical findings of Agarwal and Banerji [Opt. Lett. 27, 800 (2002)]. 相似文献
75.
A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction of acetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyl derivatives 3a–3c in the presence of potassium carbonate afforded the target compounds, namely ethyl2-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-2-oxoacetate derivatives 4a–4e, ethyl 3-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-3-oxopropanoate derivatives 4f–4i, di((4-acetyl-3-methyl-5-phenylamino)thiophen-2-yl)ketone derivatives 4j–4n in reasonable overall yields. The synthesized compounds were screened for antimicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported. 相似文献
76.
We studied transboundary groundwater management problems in the presence of hydraulic fracturing. We found that the presence of risk suggests there should be caution when considering hydraulic fracturing. Our results from the cooperative solution show a decrease in hydraulic fracturing and increase in the steady state survival rate of groundwater. We also provide a Pigouvian type tax that could be imposed on natural gas developers. 相似文献
77.
A quasi-reversible queue can be associated with certain type of transactions of a Markov chain. It is shown that if Markov chains are coupled in a certain way, then to the resulting chain be associated a queuing network which is itself quasi-reversible and the stationary distribution of the chain takes the product form. The product form for mixed networks is derived from the result for open networks. 相似文献
78.
Shirude PS Ying L Balasubramanian S 《Chemical communications (Cambridge, England)》2008,(17):2007-2009
Single molecule fluorescence spectroscopy has been employed to resolve the conformational heterogeneity, hybridization kinetics and study mutational effects on the c-MYC promoter G-quadruplex. 相似文献
79.
Waller ZA Shirude PS Rodriguez R Balasubramanian S 《Chemical communications (Cambridge, England)》2008,(12):1467-1469
The triarylpyridines are potent G-quadruplex ligands that are highly discriminating against duplex DNA and show promising selectivity between intramolecular quadruplexes. 相似文献
80.
Pravin R. Likhar M. S. Subhas Moumita Roy Sarabindu Roy M. Lakshmi Kantam 《Helvetica chimica acta》2008,91(2):259-264
Pd/C is used as an efficient catalyst for the copper‐free Sonogashira coupling of acid chlorides and terminal alkynes to afford ynones in high yields (Tables 1 and 3). Cyclization of (2‐methoxyaryl)‐substituted ynones induced by I2/ammonium cerium(IV) nitrate (CAN) at room temperature gave 3‐iodochromenones (=3‐iodo‐4H‐1‐benzopyran‐4‐ones) in excellent yield (Table 4). 相似文献