The new water-soluble photosensitizer 5,10,15,20-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl]chlorin (T3,4BCPC) has been prepared, characterized and labeled with 99mTc radionuclide. The radiotracer was evaluated for tissue distribution in Wistar rats. Accumulation of administrated activities in the liver, kidney, bladder and large intestine at 4 h post-injection indicated that the labeled ligand was largely eliminated through the renal and partly through the hepatobiliary system. In vivo biodistribution studies of the labeled compound were carried out in rodent and murine tumor models in comparison with other tumor-seeking radiopharmaceuticals such as 99mTc(V)-dimercaptosuccinic acid (DMSA), 201thallous chloride (TlCl) and 99mTc-citrate using a gamma camera computer system. In N-nitrosomethylurea (NMU)-induced rat mammary tumors, the labeled ligand showed a five-fold tumor to muscle (T/M) ratio compared to 99mTc(V)-DMSA (3-fold) and 201TlCl (3-fold). In the case of C(3)H/J virus-induced spontaneous mammary tumors, the differences were not marked. However, in the transplanted rat C(6)-glioma, the T/M ratio of the labeled compound was appreciably higher (four-fold) than that noted with 99mTc(V)-DMSA (two-fold), 201TlCl (three-fold) and 99mTc-citrate (more than three-fold). These findings suggest that the radiolabeled T3,4BCPC may have potential for the detection of cancer. In order to ascertain the efficacy of the compound for photodynamic therapy applications, a preclinical PDT study was carried out in fibrosarcoma-bearing mice after injecting 5.0 mg/kg body weight of the T3,4BCPC. A laser dose of 20 mW for 60 s resulted in 80% destruction of tumors. These data suggest that this molecule could be useful for PDT of cancer. The labeled agent could also be useful in monitoring the progression/regression of tumors before, during, and after chemotherapy, radiation therapy or PDT. 相似文献
The mass spectra of eight 1,2,4-triazole derivaties have been recorded and found tao reveal extensive hydrogen and skeletal migrations. The structures of the fragments have been confirmed by deuterium labelling and exact mass measurement. The compounds revealed striking differences in their spectra depending on the nature of the substituents. 相似文献
The reagent 2-mercaptobenzothiazole /2-HMBT/ has been used for the solvent extraction of Ru/III/. The extraction coefficient value of Ru/III/ has been evaluated, based on various parameters such as, effect of molarity of the acid, time of equilibration, time of heating, effect of various solvents and effect of various salts. The stoichiometry of the metal to reagent was determined by the method of substoichiometric extraction of slope-ratio method and was found to be 13. Separation factor and decontamination factor for various elements have also been studied. 相似文献
A new chelating resin was synthesised by the modification of styrene-divinylbenzene (2%) copolymer and incorporation of dithiocarbamate groups. The polydithiocarbamate resin was characterised by elemental analysis, thermal studies and IR studies. The analytical characteristics of the sorbent were established and optimum sorption conditions for Cu, Ni, Pb, Fe, As and Mn determined. The total sorption capacity of the resin was 37 mg g−1 for Ni(II), 35 mg g−1 for Cu(II), 29 mg g−1 for Fe(III) and 23 mg g−1 for Pb(II). The optimum pH for the removal of metal ions was 3-5 for Ni(II), 5 for Cu(II), 4 for Fe(III) and 4-5 for Pb(II). High sorption capacity was observed when compared with other conventional chelating polymers. The sorption kinetics was fairly rapid, as apparent from the loading half time t1/2 values, indicating a better accessibility of the chelating sites. 相似文献
This paper describes the effect of corona discharge on cadmium sulphide (CdS) and lead sulphide (PbS) films prepared using the chemical route. The property of films before and after exposure to corona has been described in detail. The electronic properties of the CdS and PbS films have been studied by current-voltage (I-V), capacitance-voltage (C-V) measurements. The structural properties and surface morphology were studied by using X-ray diffraction and scanning electron microscopy before and after exposing to Corona discharge. The films displayed the change in surface morphology after exposure to the corona discharge. It has been found that the films showed an increase in resistivity after exposure. This change in property has been attributed to modification in surface states. Time-dependent recovery indicated that room temperature annealing is sufficient to regain the normal resistivity of the films. The experiment was carried with the aim of studying the effect of the interaction of corona discharge on the semiconductor films and its subsequent effects. 相似文献
Particle size distribution of nanoparticles plays an important role in modelling many scientific and engineering problems. In this article, we proposed a Finite Volume Method (FVM) to model TiO2 nanoparticles formation using population balance equations (PBEs) by incorporating the simultaneous agglomeration and disintegration processes. The superposition of the PBEs for agglomeration and disintegration with different kernels leads to a system of partial-integro differential equations, which are numerically solved by using FVM. The precipitation of TiO2 nanoparticles in the batch reactor is studied experimentally as well as by numerical simulations based on Austin and Diemer disintegration kernels and Shear agglomeration kernel. Finally, the capability of the precipitation model is evaluated and the experimental results on particle sizes are compared with the numerical results.
In this paper, we discuss the two-layered Jeffrey-fluid model with mild stenosis in narrow tubes. The blood flow in narrow arteries is treated as a two-fluid model with the suspension of erythrocytes, leukocytes, etc., as a Jeffrey fluid, which is a non-Newtonian fluid, in the core region and plasma, a Newtonian fluid, in the peripheral region. An analytical solution has been obtained for the velocity in the core and peripheral region, volume flow rate, resistance to flow, and wall-shear stress. The effect of Jeffrey-fluid parameters, like the height of stenosis, viscosity, etc., on volume flow rate, resistance to flow (impedance), and wall-shear stress has been discussed graphically. Through the present study, it is found that the wall-shear stress and resistance to flow increases with the increase in height of stenosis and decreases with the increase in the ratio of relaxation time. It is also found that the velocity decreases with an increase in stenosis height in both the core and the peripheral region. A previous result has been also verified. 相似文献