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Ohne Zusammenfassung  相似文献   
73.
Cyclosporine, tacrolimus, sirolimus, and everolimus are commonly used immunosuppressants following organ transplantation. Their monitoring is used to determine the optimal dose for therapeutic effectiveness and minimize toxicity. High-performance liquid chromatographic–tandem mass spectrometry with positive electrospray ionization and multiple reaction monitoring mode was validated for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus in whole blood. A C18 analytical column was employed with a gradient elution of pH 4.0 aqueous 10?mmol/L ammonium acetate and acetonitrile. For the pretreatment of whole blood, simple protein precipitation was used with methanol:zinc sulfate. The calibration curves were linear from 20.0 to 1000?ng/mL for cyclosporine A, 1.0 to 50?ng/mL for tacrolimus and sirolimus, and 1.0 to 30?ng/mL for everolimus. The intra-assay precision and inter-assay precision were less than 15%. The method provides reliable and reproducible results according to the linearity, precision, accuracy, recovery, and matrix effects. The method has been introduced to routine clinical practice in Slovakia for the determination of immunosuppressants in patients after kidney transplantation.  相似文献   
74.
Summary The propagation of elastic and plastic waves in arbitrary spatial trusses under impact loading is considered in this paper. Particular attention is payed to the derivation of the equations which are needed to determine the distribution of the waves at the pins. Subsequently, the equations are written compactly as a matrix equation which is solved numerically. Various examples illustrate the method.
Ausbreitung von Wellen in räumlichen Stabwerken unter Stoßbelastung
Übersicht In dieser Arbeit wird die Ausbreitung von elastischen und plastischen Wellen in beliebigen räumlichen Stabwerken unter Stoßbelastung behandelt. Dabei wird der Herleitung der Gleichungen, die zur Ermittlung der Wellenaufteilung an einem Knoten benötigt werden, besondere Aufmerksamkeit gewidmet. Die Gleichungen werden anschließend zu einem Matrizensystem zusammengefaßt, das numerisch gelöst wird. Beispiele illustrieren die Methode.
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2 . By using a 0.7% prepulse that precedes the main pulse by 5 ns and applying a total pump energy of 100 J or less, the J=0-1 lasing is at least one order of magnitude higher than the non-lasing background. For the 32.6-nm line of Ti, the 25.5-nm line of Fe, and the 23.1-nm line of Ni, gain coefficients of (±) 4.20.4cm-1, (±) 3.90.3cm-1, and (±) 3.60.6cm-1, respectively, were measured for 2.4-cm-long curved targets, resulting in gain–length products of ∼10. Angle-resolved spectra indicate a beam divergence of 3 mrad (FWHM), typically. The space-resolved spectra show that the J=0-1 lasing lines are emitted from an approximately 60-μm-wide (FWHM) plasma region, whereas the nearby continuum emission is produced in a considerably broader plasma region of ∼250 μm. Lasing at 25.5 nm in neon-like iron was observed at a pump power as low as 180 GW (∼9 TW/cm2), with, however, considerable shot-to-shot scatter in the absolute laser output. Received: 5 September 1997/Revised version: 10 November 1997  相似文献   
77.
Two stochastic programming decision models are presented. In the first one, we use probabilistic constraints, and constraints involving conditional expectations further incorporate penalties into the objective. The probabilistic constraint prescribes a lower bound for the probability of simultaneous occurrence of events, the number of which can be infinite in which case stochastic processes are involved. The second one is a variant of the model: two-stage programming under uncertainty, where we require the solvability of the second stage problem only with a prescribed (high) probability. The theory presented in this paper is based to a large extent on recent results of the author concerning logarithmic concave measures.This work was supported in part by the Institute of Economic Planning, Budapest.This paper was presented at the 7th Mathematical Programming Symposium 1970, The Hague, The Netherlands, under the title Programming under probabilistic constraints and programming under constraints involving conditional expectations.  相似文献   
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The measurement of mechanical stresses in vapour quenched metal films can give additional structural information. Especially the near absence of stresses yields a sufficient condition for the formation of amorphous structures, since stress contributions due to the crystallite boundary mismatch are present in every micro crystalline film. From this point of view we find that Al films containing more than 25 at.% Ag grow in an amorphous phase whereas films with less than 25 at.% Ag are micro crystalline. The influence of other impurities, especially oxygen, is also investigated. Further evidence is presented for the high superconducting transition temperatures of Al films evaporated from Al2O3 crucibles, which films are micro crystalline, to be due to the presence of Al2O impurities in these films.  相似文献   
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