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排序方式: 共有142条查询结果,搜索用时 15 毫秒
101.
John K. Neubert Alexander A. Oliferenko Polina V. Oliferenko Sergey V. Emets David A. Ostrov Gary I. Altschuler Joe Calkins Jay Wickersham Robert Hromas Iryna O. Lebedyeva 《Molecules (Basel, Switzerland)》2021,26(4)
Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures. However, the injection itself may produce discomfort and be a source of aversion. A novel approach toward the taste modulation of local anesthetics is proposed, in which the anesthetics of the “-caine” family serve as cations and are coupled with anionic sweeteners such as saccharinate and acesulfamate. Ionic conjugates of vasoconstrictor epinephrine such as epinephrine saccharinate and epinephrine acesulfamate have also been synthesized. Novel ionic conjugates were developed using anion exchange techniques. Reported compounds are sweet-tasting and are safe to use both topically and as injections. 相似文献
102.
Natalia A. Shnayder Marina M. Petrova Tatiana E. Popova Tatiana K. Davidova Olga P. Bobrova Vera V. Trefilova Polina S. Goncharova Olga V. Balberova Kirill V. Petrov Oksana A. Gavrilyuk Irina A. Soloveva German V. Medvedev Regina F. Nasyrova 《Molecules (Basel, Switzerland)》2021,26(9)
Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treatment of them do not solve the problem of pain chronicity. This is the reason for the search for new personalized strategies for the prevention and treatment of chronic pain. The nitric oxide (NO) system can play one of the key roles in the development of peripheral pain and its chronicity. The purpose of the study is to review publications devoted to changes in the NO system in patients with peripheral chronical pain syndromes. We have carried out a search for the articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar databases. The search was carried out using keywords and their combinations. The role of NO and NO synthases (NOS) isoforms in peripheral pain development and chronicity was demonstrated primarily from animal models to humans. The most studied is the neuronal NOS (nNOS). The role of inducible NOS (iNOS) and endothelial NOS (eNOS) is still under investigation. Associative genetic studies have shown that single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes encoding nNOS, iNOS, and eNOS may be associated with acute and chronic peripheral pain. Prospects for the use of NOS inhibitors to modulate the effect of drugs used to treat peripheral pain syndrome are discussed. Associative genetic studies of SNVs NOS1, NOS2, and NOS3 genes are important for understanding genetic predictors of peripheral pain chronicity and development of new personalized pharmacotherapy strategies. 相似文献
103.
T. I. Buryakov A. I. Romanenko O. B. Anikeeva V. L. Kuznetsov A. N. Usol’tseva E. N. Tkachev 《Journal of Experimental and Theoretical Physics》2007,105(1):155-159
The influence of various gaseous media on the temperature dependence of the electric conductivity σ of multiwalled carbon nanotubes (MWNTs) synthesized using the method of catalytical chemical vapor deposition (CVD) has been studied. The σ(T) curves were measured in a temperature range from 4.2 to 300 K in helium and its mixtures with air, methane, oxygen, and hydrogen. The introduction of various gaseous components into a helium atmosphere leads to a significant decrease in the conductivity of MWNTs in the interval between the temperatures of condensation and melting of the corresponding gas. Upon a heating-cooling cycle, the conductivity restores on the initial level. It is concluded that a decrease in σ is caused by the adsorption of gases on the surface of nanotubes. 相似文献
104.
E. N. Tkachev A. I. Romanenko O. B. Anikeeva T. I. Buryakov V. E. Fedorov A. S. Nazarov V. G. Makotchenko V. L. Kuznetsov A. N. Usol’tseva 《Journal of Experimental and Theoretical Physics》2007,105(1):223-226
The effect of the modification of curvilinear carbon nanostructures (nanotubes) on their electrical properties has been studied. The samples were prepared using a special method of synthesis, which excluded the formation of amorphous carbon particles in multiwalled carbon nanotubes and in expanded graphite. Such materials exhibit a quadratic growth in the positive magnetoconductivity in the fields of up to B ~ 1 T, which is not observed in the samples synthesized by usual methods. 相似文献
105.
Exposing experimental animals or human volunteers to UVA II (320-340 nm) radiation after immunization suppresses immunologic memory and the elicitation of delayed-in-time hypersensitivity reactions. Previous studies indicated that the mechanisms underlying UVA-induced immune suppression are similar to those described for UVB-induced immune suppression, i.e. transferred by T regulatory cells, overcome by repairing DNA damage, neutralizing interleukin (IL)-10 activity, or injecting recombinant IL-12. Here we continued our examination of the mechanisms involved in UVA II-induced suppression. Antibodies to cis-urocanic acid blocked UVA-induced immune suppression. Treating UVA-irradiated mice with histamine receptor antagonists, calcitonin gene-related peptide (CGRP) receptor antagonists or platelet activating factor receptor antagonists blocked immune suppression in UVA-irradiated mice. In light of the fact that cis-urocanic acid and CGRP target mast cells, which can then release platelet activating factor and histamine, we measured UVA-induced immune suppression in mast cell-deficient mice. No immune suppression was noted in UVA-irradiated mast cell-deficient mice. These findings indicate that exposure to UVA II activates many of the same immune regulatory factors activated by UVB to induce immune suppression. Moreover, they indicate that mast cells play a critical role in UVA-induced suppression of secondary immune reactions. 相似文献
106.
Saibabu Polina V. P. Rama Kishore Putta Raghuram Gujjarappa Prasad Pralhad Pujar Chandi C. Malakar 《Journal of heterocyclic chemistry》2021,58(4):1029-1033
An efficient and mild protocol was realized using 1,2-diazoles and related heterocycles with cyclic and acyclic enones in presence of T3P (2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide) toward the regioselective formation of N-cycloalkyl heterocycles at room temperature. The developed reaction conditions showcased good selectivity over a wide range of 1,2-diazoles and enones by delivering N-cycloalkyl heterocycles in excellent yields. 相似文献
107.
Oksana Yurkevich Ksenia Maksimova Alexander Goikhman Alexey Grunin Pavel Prokopovich Alexander Tyurin Polina Medvedskaya Ivan Lyatun Irina Snigireva Anatoly Snigirev 《Journal of synchrotron radiation》2017,24(4):775-780
Beryllium, being one of the most transparent materials to X‐ray radiation, has become the material of choice for X‐ray optics instrumentation at synchrotron radiation sources and free‐electron laser facilities. However, there are concerns due to its high toxicity and, consequently, there is a need for special safety regulations. The authors propose to apply protective coatings in order to seal off beryllium from the ambient atmosphere, thus preventing degradation processes providing additional protection for users and prolonging the service time of the optical elements. This paper presents durability test results for Be windows coated with atomic‐layer‐deposition alumina layers run at the European Synchrotron Radiation Facility. Expositions were performed under monochromatic, pink and white beams, establishing conditions that the samples could tolerate without radiation damage. X‐ray treatment was implemented in various environments, i.e. vacuum, helium, nitrogen, argon and dry air at different pressures. Post‐process analysis revealed their efficiency for monochromatic and pink beams. 相似文献
108.
Liliya A. Khamidullina Igor S. Puzyrev Gennady L. Burygin Pavel V. Dorovatovskii Yan V. Zubavichus Anna V. Mitrofanova Victor N. Khrustalev Tatiana V. Timofeeva Pavel A. Slepukhin Polina D. Tobysheva Alexander V. Pestov Euro Solari Alexander G. Tskhovrebov Valentine G. Nenajdenko 《Molecules (Basel, Switzerland)》2021,26(21)
Copper(II) complexes with 1,1,1-trifluoro-4-(4-methoxyphenyl)butan-2,4-dione (HL1) were synthesized and characterized by elemental analysis, FT-IR spectroscopy, and single crystal X-ray diffraction. The biological properties of HL1 and cis-[Cu(L1)2(DMSO)] (3) were examined against Gram-positive and Gram-negative bacteria and opportunistic unicellular fungi. The cytotoxicity was estimated towards the HeLa and Vero cell lines. Complex 3 demonstrated antibacterial activity towards S. aureus comparable to that of streptomycin, lower antifungal activity than the ligand HL1 and moderate cytotoxicity. The bioactivity was compared with the activity of compounds of similar structures. The effect of changing the position of the methoxy group at the aromatic ring in the ligand moiety of the complexes on their antimicrobial and cytotoxic activity was explored. We propose that complex 3 has lower bioavailability and reduced bioactivity than expected due to strong intermolecular contacts. In addition, molecular docking studies provided theoretical information on the interactions of tested compounds with ribonucleotide reductase subunit R2, as well as the chaperones Hsp70 and Hsp90, which are important biomolecular targets for antitumor and antimicrobial drug search and design. The obtained results revealed that the complexes displayed enhanced affinity over organic ligands. Taken together, the copper(II) complexes with the trifluoromethyl methoxyphenyl-substituted β-diketones could be considered as promising anticancer agents with antibacterial properties. 相似文献
109.
Valeria Tafintseva Tiril Aurora Lintvedt Johanne Heitmann Solheim Boris Zimmermann Hafeez Ur Rehman Vesa Virtanen Rubina Shaikh Ervin Nippolainen Isaac Afara Simo Saarakkala Lassi Rieppo Patrick Krebs Polina Fomina Boris Mizaikoff Achim Kohler 《Molecules (Basel, Switzerland)》2022,27(3)
The aim of the study was to optimize preprocessing of sparse infrared spectral data. The sparse data were obtained by reducing broadband Fourier transform infrared attenuated total reflectance spectra of bovine and human cartilage, as well as of simulated spectral data, comprising several thousand spectral variables into datasets comprising only seven spectral variables. Different preprocessing approaches were compared, including simple baseline correction and normalization procedures, and model-based preprocessing, such as multiplicative signal correction (MSC). The optimal preprocessing was selected based on the quality of classification models established by partial least squares discriminant analysis for discriminating healthy and damaged cartilage samples. The best results for the sparse data were obtained by preprocessing using a baseline offset correction at 1800 cm−1, followed by peak normalization at 850 cm−1 and preprocessing by MSC. 相似文献
110.
Olga Shilova Polina Kotelnikova Galina Proshkina Elena Shramova Sergey Deyev 《Molecules (Basel, Switzerland)》2021,26(22)
Barnase is an extracellular ribonuclease secreted by Bacillus amyloliquefaciens that was originally studied as a small stable enzyme with robust folding. The identification of barnase intracellular inhibitor barstar led to the discovery of an incredibly strong protein-protein interaction. Together, barnase and barstar provide a fully genetically encoded toxin-antitoxin pair having an extremely low dissociation constant. Moreover, compared to other dimerization systems, the barnase-barstar module provides the exact one-to-one ratio of the complex components and possesses high stability of each component in a complex and high solubility in aqueous solutions without self-aggregation. The unique properties of barnase and barstar allow the application of this pair for the engineering of different variants of targeted anticancer compounds and cytotoxic supramolecular complexes. Using barnase in suicide gene therapy has also found its niche in anticancer therapy. The application of barnase and barstar in contemporary experimental cancer therapy is reflected in the review. 相似文献