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61.
As part of our program to prepare substituted rtaphthoquinones with potential biological activity1 we have synthetized 6, 7-methyleriedioxy-3-alky 1 lawsones (5a-g) from natural safrole (1) and carboxylic' acids (~50% overall yield). 相似文献
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Sandra C. C. Nunes P. Pinto A. A. C. C. Pais 《Journal of computational chemistry》2013,34(14):1198-1209
Adsorption phenomena are relevant in a wide variety of subjects, from biophysics to technological applications. Different aspects, such as molecular recognition, multilayer deposition, and dynamics of polymer adsorption have been addressed. The methodologies used range from analytical and numerical methods to molecular dynamics or Monte Carlo simulations. In this work, a coarse‐grained model is used to explore the adsorption of charged backbones to oppositely charged regions of a surface. These regions encompass those small enough to prevent complete adsorption, but extend to surfaces sufficiently large to promote adsorption with minimal effect on the three‐dimensional conformation in bulk. Apart from the different surface areas explored, variations on the surface charge density, polyelectrolyte chain length, and chain stiffness were also considered. The degree of compaction of the polyelectrolyte, on adsorption, is different from that found in the bulk. Also, results indicate an nonuniform adsorption pattern on regularly charged surfaces. © 2013 Wiley Periodicals, Inc. 相似文献
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Theolyta S. Araújo Claudener S. Teixeira Maria A. P. Falcão Vanir R. Pinto Junior Mayara Quiroz Santiago Raquel G. Benevides Plínio Delatorre Jorge L. Martins Magna S. Alexandre-Moreira Benildo S. Cavada Eliane A. Campesatto Bruno A. M. Rocha 《Applied biochemistry and biotechnology》2013,171(8):1944-1955
Lectins are a structurally heterogeneous group of proteins or glycoproteins with at least one noncatalytic domain binding reversibly to a specific mono- or oligosaccharide. Monocot mannose-binding lectins are an extended superfamily of structurally and evolutionarily related proteins. In this study, we evaluated anti-inflammatory and antinociceptive effects of monocot lectin from the Canna limbata seeds (CLL). To accomplish this, CLL was purified and subjected to pharmacological assays: abdominal writhing induced by acetic acid, formalin, hot plate and Zymosan A-induced peritonitis tests. The CLL was purified by chromatographic chitin column, and the relative mass of 21 kDa observed in electrophoresis was confirmed by electrospray mass spectrometry, which also revealed that purified CLL consists of a dimer having a weight of 49,676 Da. The CLL showed nociceptive activity in the acetic acid test as well as peripheral antinociceptive response. The CLL also showed anti-inflammatory effect with the reduction of inflammation in the formalin test and neutrophil migration into the peritoneal cavity. This is the first report of anti-inflammatory activity for a monocot lectin, and it suggests a new pharmacological tool to understand inflammatory and antinociceptive processes mediated through lectins. 相似文献
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Ionic liquids as stationary phases in gas chromatography: Determination of chlorobenzenes in soils
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Rosa María González Paredes Carmelo García Pinto José Luis Pérez Pavón Bernardo Moreno Cordero 《Journal of separation science》2014,37(12):1448-1455
The present research focuses on the evaluation of different ionic liquid (IL) stationary phases in gas chromatography. The different IL columns were evaluated in terms of peak resolution (Rs) and peak symmetry for the separation of the chlorobenzenes. The determination of chlorobenzenes in soil samples by means of the optimal IL stationary phase (SLB‐IL82) is proposed as an application. Soil pretreatment was based on a simplified quick, easy, cheap, effective, rugged, and safe extraction procedure and a large injection volume via a programed temperature vaporizer working in solvent vent mode. The retention time of the chlorobenzenes increased as the polarity of the IL column decreased. SLB‐IL82 is the stationary phase that provides the best values as regards Rs and asymmetry factor. Soil sample blanks were spiked with the analytes before subjecting the sample to the extraction process. The existence of a matrix effect was checked and the analytical characteristics of the method were determined in a fortified garden soil sample. The method provided good linearity, good repeatability and reproducibility values, and the LODs were in the 0.1–4.7 μg/kg range. Two fortified soil samples were applied to validate the proposed methodology. 相似文献
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Victoria Mánuel Juan J. Pinto Carolina Mendiguchía Carlos Moreno 《Central European Journal of Chemistry》2014,12(3):348-353
In this work, Cd(II) extraction in natural waters by organophosphorus extractants as organic phase, as well as its back-extraction in an acidic media, has been studied. Cadmium extraction behavior at natural waters’ pH conditions (values in the range 7–8) was studied with two different extractants and co-ions, obtaining the highest extraction efficiency when using 0.1M Cyanex 272 in kerosene as organic phase and 0.1 M NO3 ? as co-ion. Once they were selected, the effect on the extraction efficiency of sample pH, buffer concentration, extraction time, Cyanex 272 concentration as well as back-extractant concentration, was studied. The presence of the main inorganic and organic ligands in the sample was also studied, observing that extraction efficiency was affected most significantly when chlorides were present, with a decrease of about 14%, proving negligible for the others. Under the selected conditions, spiked real samples were successfully analyzed. 相似文献
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Ana Margarida Silva Diana Pinto Iva Fernandes Victor de Freitas María de la Luz Cdiz-Gurrea Paulo Costa Cristina Delerue-Matos Francisca Rodrigues 《Molecules (Basel, Switzerland)》2021,26(8)
During kiwiberry production, different by-products are generated, including leaves that are removed to increase the fruit’s solar exposure. The aim of this work was to extract bioactive compounds from kiwiberry leaf by employing microwave-assisted extraction (MAE). Compatible food solvents (water and ethanol) were employed. The alcoholic extract contained the highest phenolic and flavonoid contents (629.48 mg of gallic acid equivalents (GAE) per gram of plant material on dry weight (dw) (GAE/g dw) and 136.81 mg of catechin equivalents per gram of plant material on dw (CAE/g dw), respectively). Oppositely, the hydroalcoholic extract achieved the highest antioxidant activity and scavenging activity against reactive oxygen and nitrogen species (IC50 = 29.10 μg/mL for O2•−, IC50 = 1.87 μg/mL for HOCl and IC50 = 1.18 μg/mL for •NO). The phenolic profile showed the presence of caffeoylquinic acids, proanthocyanidin, and quercetin in all samples. However, caffeoylquinic acids and quercetin were detected in higher amounts in the alcoholic extract, while proanthocyanidins were prevalent in the hydroalcoholic extract. No adverse effects were observed on Caco-2 viability, while the highest concentration (1000 µg/mL) of hydroalcoholic and alcoholic extracts conducted to a decrease of HT29-MTX viability. These results highlight the MAE potentialities to extract bioactive compounds from kiwiberry leaf. 相似文献