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排序方式: 共有128条查询结果,搜索用时 15 毫秒
61.
Dr. Chen Zhang Dr. Pierre-Yves Fortin Guillaume Barnoin Xue Qin Xing Wang Dr. Alvaro Fernandez Alvarez Dr. Christian Bijani Dr. Marie-Lise Maddelein Dr. Catherine Hemmert Dr. Olivier Cuvillier Prof. Dr. Heinz Gornitzka 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(29):12160-12166
62.
Dr. Cédric Bergerbit Florian Baffie Dr. Arne Wolpers Pierre-Yves Dugas Olivier Boyron Manel Taam Dr. Muriel Lansalot Dr. Vincent Monteil Dr. Franck D'Agosto 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(26):10471-10476
Poly(ethylene oxide) (PEO) with dithiocarbamate chain ends (PEO–SC(=S)−N(CH3)Ph and PEO–SC(=S)−NPh2, named PEO-1 and PEO-2 , respectively) were used as macromolecular chain-transfer agents (macro-CTAs) to mediate the reversible addition–fragmentation chain transfer (RAFT) polymerization of ethylene in dimethyl carbonate (DMC) under relatively mild conditions (80 °C, 80 bar). While only a slow consumption of PEO-1 was observed, the rapid consumption of PEO-2 led to a clean chain extension and the formation of a polyethylene (PE) segment. Upon polymerization, the resulting block copolymers PEO-b-PE self-assembled into nanometric objects according to a polymerization-induced self-assembly (PISA). 相似文献
63.
Niu SL Massif C Ulrich G Ziessel R Renard PY Romieu A 《Organic & biomolecular chemistry》2011,9(1):66-69
The synthesis and preliminary bio-conjugation studies of a novel water-soluble red-emitting di-styryl BODIPY dye are disclosed. Aggregation behaviour of this compound under physiological conditions was suppressed by specific introduction of a di-sulfonated peptide-based linker at the meso phenyl substituent, sultonated styryl arms and short polyethyleneglycol chains at the boron center. Thus, a good quantum yield of 22% in PBS for this red-emitting BODIPY was obtained. Introduction of an activated ester function enabled successful bio-conjugation to monoclonal antibodies and proteins. 相似文献
64.
A natural product biosynthesis-inspired strategy to explore biologically relevant chemical space is presented. A phosphine-catalyzed cascade and stereoselective annulation provides a common tricyclic benzopyrone intermediate that was efficiently transformed into diverse and related naturally occurring scaffolds. 相似文献
65.
Tristan Verdelet Guillaume Mercey Nobi Correa Ludovic Jean Pierre-Yves Renard 《Tetrahedron》2011,67(45):8757-8762
A practical and rapid preparation of 3-benzyloxy-4-bromo and 3-benzyloxy-5-bromopicolinate esters 10 and 16 was developed in four steps, respectively, in 38% and 31% overall yield. Then their viability as partners for cross-coupling reactions has been evaluated in Suzuki-Miyaura, Hartwig-Buchwald, and Sonogashira reactions to synthesize biologically relevant targets. The preparation of these two highly functionalizable pyridines 10 and 16 has been never described to date in the literature and could be used as common building block for the preparation of several biologically active compounds or agrochemical products. 相似文献
66.
Fabien Dutertre Pierre-Yves Pennarun Olivier Colombani Erwan Nicol 《European Polymer Journal》2011,(3):343-351
Lauryl (LA) and stearyl (SA) acrylates were successfully polymerized by atom transfer radical polymerization (ATRP), leading to well defined homopolymers and diblock copolymers (PDI < 1.2). Interestingly, the polymerization was very well controlled using N,N,N′,N″,N″-pentamethyldiethylenetriamine (PMDETA), a ligand which had initially been reported to be unadvisable for the polymerization of such monomers. Both kinetic studies and chain extension reactions supported our conclusions. A PLA65-b-PSA47 diblock copolymer was characterized by differential scanning calorimetry and dynamic thermo-mechanical analysis, revealing that both blocks exhibit side-chain crystallinity and phase segregate in the crystalline state. The diblock behaves as a brittle rigid polymer when both blocks are crystalline, as a ductile material after the melting of the PLA phase and becomes a viscous liquid when both blocks are molten. This work could be extended to the preparation of PSA-b-PLA-b-PSA bio-issued thermoplastic elastomers. 相似文献
67.
Dr. Alexis Lossouarn Chloé Puteaux Laetitia Bailly Dr. Vincent Tognetti Prof. Laurent Joubert Prof. Pierre-Yves Renard Dr. Cyrille Sabot 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(62):e202202180
Proteins are able to irreversibly assemble biologically active ligands from building blocks bearing complementary reactive functions due their spatial proximity, through a kinetic target-guided synthetic process (also named in situ click chemistry). Although linkages thus formed are mostly passive, some of them have shown to significantly contribute to the protein binding through for instance hydrogen bonding and stacking interactions. Biocompatible reactions and click chemistry are a formidable source of inspiration for developing such new protein-directed ligations. This study reports a proximity-induced thiol-yne synthesis of carbonic anhydrase inhibitors. Not only this example widens the arsenal of kinetic target-guided synthesis (KTGS) eligible reactions, but the obtained product displayed unsuspected photophysical properties. The corresponding vinyl sulfide linkage conjugated to a coumarin core proved to be engaged in a monodirectional Z to E photoisomerization process. Further investigations guided by theoretical calculations showed that fine-tuning of the nature of the substituents on the coumarin moiety allows to obtain a bidirectional photochemical process, thus discovering a new photoswitching moiety, displaying moreover fluorescence properties. Due to the spectral tunability of coumarin derivatives, this work should open new opportunities for the design of vinyl sulfide-based photoswitch systems with modular photophysical properties. 相似文献
68.
Anatoxin-a analogue was prepared by resolution of aminoacid 1 using chiral (R)-4-phenyl-oxazolidin-2-thione as derivatizing agent. X-ray diffraction of a diastereomer allowed us to determine its absolute configuration. The synthesis could then be completed in few steps followed by introduction of an amide linker bearing a terminal alkyne in order to attach a carrier protein for monoclonal antibodies production. 相似文献
69.
Lapeyre M Leprince J Massonneau M Oulyadi H Renard PY Romieu A Turcatti G Vaudry H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(13):3655-3671
The development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioethyloxycarbonyl (Pydec) protecting groups, which are thiol-labile urethanes, is described. These new disulfide-based protecting groups were introduced onto the epsilon-amino group of L-lysine; the resulting amino acid derivatives were easily converted into N alpha-Fmoc building blocks suitable for both solid- and solution-phase peptide synthesis. Model dipeptide(Ardec)s were prepared by using classical peptide couplings followed by standard deprotection protocols. They were used to optimize the conditions for complete thiolytic removal of the Ardec groups both in aqueous and organic media. Phdec and Pydec were found to be cleaved within 15 to 30 min under mild reducing conditions: i) by treatment with dithiothreitol or beta-mercaptoethanol in Tris.HCl buffer (pH 8.5-9.0) for deprotection in water and ii) by treatment with beta-mercaptoethanol and 1,8-diazobicyclo[5.4.0]undec-7-ene (DBU) in N-methylpyrrolidinone for deprotection in an organic medium. Successful solid-phase synthesis of hexapeptides Ac-Lys-Asp-Glu-Val-Asp-Lys(Ardec)-NH2 has clearly demonstrated the full orthogonality of these new amino protecting groups with Fmoc and Boc protections. The utility of the Ardec orthogonal deprotection strategy for site-specific chemical modification of peptides bearing several amino groups was illustrated firstly by the preparation of a fluorogenic substrate for caspase-3 protease containing the cyanine dyes Cy 3.0 and Cy 5.0 as FRET donor/acceptor pair, and by solid-phase synthesis of an hexapeptide bearing a single biotin reporter group. 相似文献
70.