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41.
42.
A new apparatus for the extraction of organic compounds from sea water is described. With this apparatus it is possible to extract 54 standard compounds with high recovery percentages from 9 1 of sea water with 3 ml ofn-hexane. The analysis time (about 1 h) is appreciably lower than those of the extraction methods based on RP-18 and Carbopack-B adsorption (about 15 h). Furthermore, it is possible to analyze samples without filtration. An application of this method to the analysis of Tirreno sea water is reported. 相似文献
43.
J. Gaca M. Wójcik A. Jasik K. Pierściński M. Kosmala A. Turos A. M. Abdul-Kaderd 《Opto-Electronics Review》2008,16(1):12-17
GaAs/AlAs Bragg mirrors on GaAs with varied number of layer pairs were grown, by molecular beam epitaxy (MBE), to be applied
for semiconductor saturable absorber mirrors (SESAMs) and intensity modulators. Due to the random variation of the growth
rate, substrate surface roughness, and interdiffusion at the interfaces, precise control of the growth conditions of deposited
layers poses a serious problem. Usually, thickness variations and composition grading at the heterointefaces result in variations
of the mirror reflectivity. In this paper, the high resolution X-ray diffraction (HRXRD), optical reflectance, Rutherford
backscattering/channelling (RBS), supported by numerical evaluation methods were employed to determine both the exact thickness
of each layer and the composition grading at the interface between succeeding layers of GaAs/AlAs-based mirrors. To reduce
ambiguity and to speed up the analysis, the rocking curves and RBS spectra were simulated concurrently, using results of one
simulation to verify the others. This process was carried out until the best fit between experimental and calculated curves
was achieved. The complementary use of both methods results in improved sensitivity and makes the whole process of evaluation
of the thickness variation of each layer and the size of the composition grading at the interfaces less time consuming. 相似文献
44.
Anna Laura Segre Fulvio Andruzzi Corrado Barone Massimo Paci Pier Luigi Magagnini 《Journal of Polymer Science.Polymer Physics》1985,23(12):2611-2621
The 13C NMR spectra of aromatic comblike polyesters obtained from 1,2-icosanediol and isomeric phthalic acids are reported and discussed. The analysis shows that the most informative spectral regions are those of the carbonyl and quaternary carbon resonances, whose peak multiplicities have been interpreted in terms of dyad and triad sequences. The results indicate that the extent of structural characterization possible for the polymers examined is dependent on the type of isomerism of the aromatic acid involved. 相似文献
45.
Dell'Orco D Seeber M De Benedetti PG Fanelli F 《Journal of chemical information and modeling》2005,45(5):1429-1438
Fragment complementation is gaining an increasing impact as a nonperturbing method to probe noncovalent interactions within protein supersecondary structures. In this study, the fast Fourier transform rigid-body docking algorithm ZDOCK has been employed for in silico reconstitution of the calcium binding protein calbindin D9k, from its two EF-hands subdomains, namely, EF1 (residues 1-43) and EF2 (residues 44-75). The EF1 fragment has been used both in its wild type and in nine mutant forms, in line with in vitro experiments. Consistent with in vitro data, ZDOCK reconstituted the proper fold of wild-type and mutated calbindin, locating the nativelike structures (i.e., holding a root-mean-square deviation < 1 A with respect to the X-ray structure) among the first 10 top-scored solutions out of 4000. Moreover, the three independent in silico reconstitutions of wild-type calbindin ranked a nativelike structure at the top of the output list, that is, the best scored one. The algorithm has been also successfully challenged in reconstituting the EF2 homodimer from two identical copies of the monomer. Furthermore, quantitative models consisting of linear correlations between thermodynamic data and ZDOCK scores were built, providing a tested tool for very fast in silico predictions of the free energy of association of protein-protein complexes solved at the atomic level and known to not undergo significant conformational changes upon binding. 相似文献
46.
Recent experiments on rocks and other materials, such as soil, cement, concrete and damaged elastic materials, have led to the discovery of nonlinear (NL) hysteretic effects in their elastic behaviour. These observations suggest the existence of a NL mesoscopic elasticity universality class, to which all the aforementioned materials belong. The purpose of the present contribution is to search for the basic mathematical roots for nonclassical nonlinearity, in order to explain its universality, classify it and correlate it with the underlying meso- or microscopic interaction mechanisms. In our discussions we explicitly consider two quite different kinds of specimens: a two-bonded-elements structure and a thin multigrained bar. It is remarkable that, although the former includes only one interface and the latter very many interstices, the same "interaction box" formalism can be applied to both. Another important result of the proposed formalism is that the spectral contents of an arbitrary system for any input amplitude may be predicted, under certain assumptions, from the result of a single experiment at a higher amplitude. 相似文献
47.
Seeber M De Benedetti PG Fanelli F 《Journal of chemical information and computer sciences》2003,43(5):1520-1531
Comparative molecular dynamics simulations of the 5-HT(1A) receptor in its empty as well as agonist- (i.e. active) and antagonist-bound (i.e. nonactive) forms have been carried out. The agonists 5-HT and (R)-8-OH-DPAT as well as the antagonist WAY100635 have been employed. The results of this study strengthen the hypothesis that the receptor portions close to the E/DRY/W motif, with prominence to the cytosolic extensions of helices 3 and 6, are particularly susceptible to undergo structural modification in response to agonist binding. Despite the differences in the structural/dynamics behavior of the two agonists when docked into the 5-HT(1A) receptor, they both exert a destabilization of the intrahelical and interhelical interactions found in the empty and antagonist-bound receptor forms between the arginine of the E/DRY sequence and both D133(3.49) and E340(6.30). For both agonists, the chemical information transfer from the extracellular to the cytosolic domains is mediated by a cluster of aromatic amino acids in helix 6, following the ligand interaction with selected amino acids in the extracellular half of the receptor, such as D116(3.32), S199(5.42), Y195(5.38), and F361(6.51). A significant reduction in the bend at P360(6.50), as compared to the empty and the antagonist-bound receptor forms, is one of the features of the agonist-bound forms that is related to the breakage of the interhelical salt bridge between the E/DRY arginine and E340(6.30). Another structural feature, shared by the agonist-bound receptor forms and not by the empty and antagonist-bound forms, is the detachment of helices 2 and 4, as marked by the movement of W161(4.50) away from helix 2, toward the membrane space. 相似文献
48.
Pier Luigi Ferrarini Claudio Mori Giuliana Biagi Oreste Livi Imperio Tonetti 《Journal of heterocyclic chemistry》1984,21(2):417-419
Some 1,8-naphthyridine nitrogen mustards have been synthesized for studies of their antitumor potentialities. All the tested intermediate and target compounds are devoid of antitumor properties. 相似文献
49.
Gialiana Biagi Irene Giorgi Oreste Livi Valerio Scartoni Silvia Velo Pier Luigi Barili 《Journal of heterocyclic chemistry》1996,33(6):1847-1853
A new 4-(benzotriazol-1-yl)-1,2,3-triazole structure was obtained by the diazotization reaction of either of 1-(2-aminophenyl)-4-carboxamido-5-amino-1H-1,2,3-triazole ( 1c ) or of the corresponding Dimroth isomer 1d . It underwent some common reactions to evaluate its chemical behaviour and structure. An analogous reaction sequence was carried out from the 2-nitro-4-methylphenyl azide, to assign the structure to the nitro derivatives prepared. The structure of the new compounds prepared was confirmed by chemical and spectroscopic methods. 相似文献
50.
Bortolini O Fantin G Fogagnolo M Giovannini PP Massi A Pacifico S 《Organic & biomolecular chemistry》2011,9(24):8437-8444
An efficient method for the N-heterocyclic carbene (NHC)-catalyzed conjugate addition of acetyl anions to various α,β-unsaturated acceptors (Stetter reaction) has been optimized by using 2,3-butandione (biacetyl) as an alternative surrogate of acetaldehyde. The disclosed procedure proved to be compatible with microwave dielectric heating for reaction time reduction and with the use of different linear α-diketones as acyl anion donors (e.g. 3,4-hexanedione for propionyl anion additions). Moreover, the unprecedented umpolung reactivity of cyclic α-diketones in the atom economic nucleophilic acylation of chalcones is herein presented. Mechanistic aspects of the thiazolium-based catalysis involving linear and cyclic α-diketone substrates are also discussed. 相似文献