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11.
Phu H. Dang Tho H. Le Phuong K.T. Phan Phuong T.T. Le Mai T.T. Nguyen Nhan T. Nguyen 《Tetrahedron letters》2017,58(16):1553-1557
Two acridones, paratrimerins C (1) and D (2), and two coumarins, paratrimerins E (3) and F (4), were isolated from the CHCl3 and EtOAc extracts of Paramignya trimera (Rutaceae), together with twelve known compounds (5–16). Their structures were elucidated on the basis of spectroscopic data. All isolated compounds possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 14.6 to 112.2 μM, than the positive control acarbose (IC50, 214.5 μM). The biosynthesis of the isolated coumarins and acridones was proposed. 相似文献
12.
Background
Activation of fatty acids by acyl-CoA synthetase enzymes is required for de novo lipid synthesis, fatty acid catabolism, and remodeling of biological membranes. Human long-chain acyl-CoA synthetase member 6, ASCL6, is a form present in the plasma membrane of cells. Splicing events affecting the amino-terminus and alternative motifs near the ATP-binding site generate different isoforms of ACSL6. 相似文献13.
Phuong Khanh Nguyen Teodor Gabriel Crainic Michel Toulouse 《Journal of Heuristics》2014,20(4):383-416
We propose a new population-based hybrid meta-heuristic for the periodic vehicle routing problem with time windows. This meta-heuristic is a generational genetic algorithm that uses two neighborhood-based meta-heuristics to optimize offspring. Local search methods have previously been proposed to enhance the fitness of offspring generated by crossover operators. In the proposed method, neighborhood-based meta-heuristics are used for their capacity to escape local optima, and deliver optimized and diversified solutions to the population of the next generation. Furthermore, the search performed by the neighborhood-based meta-heuristics repairs most of the constraint violations that naturally occur after the application of the crossover operators. The genetic algorithm we propose introduces two new crossover operators addressing the periodic vehicle routing problem with time windows. The two crossover operators are seeking the diversification of the exploration in the solution space from solution recombination, while simultaneously aiming not to destroy information about routes in the population as computing routes is NP-hard. Extensive numerical experiments and comparisons with all methods proposed in the literature show that the proposed methodology is highly competitive, providing new best solutions for a number of large instances. 相似文献
14.
Mustapha Hellou Thi Diep Phuong Bach 《Zeitschrift für Angewandte Mathematik und Physik (ZAMP)》2011,11(3):135-147
The purpose of this study is to calculate Stokes flow structures in relation to flow rate distribution in a junction of four
orthogonal channels. Particular attention was paid to the existence of recirculation flow inside the channels for low Reynolds
numbers. The presence of this recirculation flow may be observed, but only when the flow rate is relatively low in at least
one of the branches. 相似文献
15.
Le Thi Phuong Ngoc Nguyen Anh Triet Nguyen Thanh Long 《Nonlinear Analysis: Theory, Methods & Applications》2010,72(3-4):1865-1885
The paper is devoted to the study of a linear wave equation with a nonlinear boundary condition of viscoelastic type. The existence of a weak solution is proved by using the Faedo–Galerkin method. The uniqueness, regularity and asymptotic expansion of the solution are also discussed. 相似文献
16.
Let (P) denote the vector maximization problem
where the objective functions f
i
are strictly quasiconcave and continuous on the feasible domain D, which is a closed and convex subset of R
n
. We prove that if the efficient solution set E(P) of (P) is closed, disconnected, and it has finitely many (connected) components, then all the components are unbounded. A similar fact is also valid for the weakly efficient solution set E
w
(P) of (P). Especially, if f
i
(i=1,...,m) are linear fractional functions and D is a polyhedral convex set, then each component of E
w
(P) must be unbounded whenever E
w
(P) is disconnected. From the results and a result of Choo and Atkins [J. Optim. Theory Appl. 36, 203–220 (1982.)] it follows that the number of components in the efficient solution set of a bicriteria linear fractional vector optimization problem cannot exceed the number of unbounded pseudo-faces of D. 相似文献
17.
Classical molecular dynamics simulations of the folding of alanine peptides in aqueous solution are analyzed by constructing a deterministic model of the dynamics, using methods from nonlinear time series analysis. While the dimension of the free energy landscape increases with system size, a Lyapunov analysis shows that the effective dimension of the dynamic system is rather small and even decreases with chain length. The observed reduction of phase space is a nonlinear cooperative effect that is caused by intramolecular hydrogen bonds that stabilize the secondary structure of the peptides. 相似文献
18.
Le Thi Phuong Ngoc Nguyen Anh Triet Alain Pham Ngoc Dinh 《Numerical Functional Analysis & Optimization》2017,38(9):1173-1207
In this paper, we consider a wave equation with integral nonlocal boundary conditions of memory type. First, we establish two local existence theorems by using Faedo–Galerkin method and standard arguments of density. Next, we give a su?cient condition to guarantee the global existence and exponential decay of weak solutions. Finally, we present numerical results. 相似文献
19.
Ta HP Berthelot K Coulary-Salin B Desbat B Géan J Servant L Cullin C Lecomte S 《Langmuir : the ACS journal of surfaces and colloids》2011,27(8):4797-4807
Many in vitro studies have pointed out the interaction between amyloids and membranes, and their potential involvement in amyloid toxicity. In a previous study, we generated a yeast toxic mutant (M8) of the harmless model amyloid protein HET-s((218-289)). In this study, we compared the self-assembling process of the nontoxic wild-type (WT) and toxic (M8) protein at the air-water interface and in interaction with various phospholipid monolayers (DOPE, DOPC, DOPI, DOPS and DOPG). We first demonstrate using ellipsometry measurements and polarization-modulated infrared reflection absorption spectroscopy (PMIRRAS) that the air-water interface promotes and modifies the assembly of WT since an amyloid-like film was instantaneously formed at the interface with an antiparallel β-sheet structuration instead of the parallel β-sheet commonly observed for amyloid fibers generated in solution. The toxic mutant (M8) behaves in a similar manner at the air-water interface or in bulk, with a fast self-assembling and an antiparallel β-sheet organization. The transmission electron microscopy (TEM) images established the fibrillous morphology of the protein films formed at the air-water interface. Second, we demonstrate for the first time that the main driving force between this particular fungus amyloid and membrane interaction is based on electrostatic interactions with negatively charged phospholipids (DOPG, DOPI, DOPS). Interestingly, the toxic mutant (M8) clearly induces perturbations of the negatively charged phospholipid monolayers, leading to a massive surface aggregation, whereas the nontoxic (WT) exhibits a slight effect on the membrane models. This study allows concluding that the toxicity of the M8 mutant could be due to its high propensity to interact with membranes. 相似文献
20.
Le Thi Phuong Ngoc Nguyen Thanh Long 《Nonlinear Analysis: Theory, Methods & Applications》2011,74(18):7111-7125
Motivated by the recent known results about the solvability and existence of asymptotically stable solutions for nonlinear functional integral equations in spaces of functions defined on unbounded intervals with values in the n-dimensional real space, we establish asymptotically stable solutions for a nonlinear functional integral equation in the space of all continuous functions on R+ with values in a general Banach space, via a fixed point theorem of Krasnosel’skii type. In order to illustrate the result obtained here, an example is given. 相似文献