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排序方式: 共有960条查询结果,搜索用时 15 毫秒
951.
Tan YC Hettiarachchi K Siu M Pan YR Lee AP 《Journal of the American Chemical Society》2006,128(17):5656-5658
Cells have been encapsulated inside lipid vesicles by using a new microfluidic lipid vesicle formulation technique. Lipid vesicles are formulated within minutes without using toxic lipid solvents. The encapsulation efficiency inside the vesicles is controlled by the microfluidic flows. Green fluorescent proteins (GFP), carcinoma cells, and bead encapsulated vesicles have mean diameters of 27.2 mum, 62.4 mum, and 55.9 mum, respectively. The variations of vesicle sizes are approximately 20% for the GFP and cell encapsulated vesicles and approximately 10% for the bead encapsulated vesicles. 相似文献
952.
Phillip S. Harrington 《Mathematische Zeitschrift》2009,262(1):199-217
Let be a bounded pseudoconvex domain with C
k
boundary, k ≥ 1. In this paper, we will prove that the Cauchy–Riemann operator has a bounded solution operator in the Sobolev space for all . 相似文献
953.
Jerald E. Hertzog Vincent J. Maddi Laura F. Hart Benjamin W. Rawe Phillip M. Rauscher Katie M. Herbert Eric P. Bruckner Juan J. de Pablo Stuart J. Rowan 《Chemical science》2022,13(18):5333
Ring size is a critically important parameter in many interlocked molecules as it directly impacts many of the unique molecular motions that they exhibit. Reported herein are studies using one of the largest macrocycles reported to date to synthesize doubly threaded [3]rotaxanes. A large ditopic 46 atom macrocycle containing two 2,6-bis(N-alkyl-benzimidazolyl)pyridine ligands has been used to synthesize several metastable doubly threaded [3]rotaxanes in high yield (65–75% isolated) via metal templating. Macrocycle and linear thread components were synthesized and self-assembled upon addition of iron(ii) ions to form the doubly threaded pseudo[3]rotaxanes that could be subsequently stoppered using azide–alkyne cycloaddition chemistry. Following demetallation with base, these doubly threaded [3]rotaxanes were fully characterized utilizing a variety of NMR spectroscopy, mass spectrometry, size-exclusion chromatography, and all-atom simulation techniques. Critical to the success of accessing a metastable [3]rotaxane with such a large macrocycle was the nature of the stopper group employed. By varying the size of the stopper group it was possible to access metastable [3]rotaxanes with stabilities in deuterated chloroform ranging from a half-life of <1 minute to ca. 6 months at room temperature potentially opening the door to interlocked materials with controllable degradation rates.Multiple metastable doubly threaded [3]rotaxanes using a large 46 atom ring were prepared and fully characterized. Varying the stopper group size gave a range of interlocked stabilities in CDCl3 from a half-life of <1 minute to ca. 6 months. 相似文献
954.
Leila Takahashi-Ruiz Joseph D. Morris Phillip Crews Tyler A. Johnson April L. Risinger 《Molecules (Basel, Switzerland)》2022,27(13)
Microtubule-stabilizing agents (MSAs) are a class of compounds used in the treatment of triple-negative breast cancer (TNBC), a subtype of breast cancer where chemotherapy remains the standard-of-care for patients. Taxanes like paclitaxel and docetaxel have demonstrated efficacy against TNBC in the clinic, however new classes of MSAs need to be identified due to the rise of taxane resistance in patients. (−)-Zampanolide is a covalent microtubule stabilizer that can circumvent taxane resistance in vitro but has not been evaluated for in vivo antitumor efficacy. Here, we determine that (−)-zampanolide has similar potency and efficacy to paclitaxel in TNBC cell lines, but is significantly more persistent due to its covalent binding. We also provide the first reported in vivo antitumor evaluation of (−)-zampanolide where we determine that it has potent and persistent antitumor efficacy when delivered intratumorally. Future work on zampanolide to further evaluate its pharmacophore and determine ways to improve its systemic therapeutic window would make this compound a potential candidate for clinical development through its ability to circumvent taxane-resistance mechanisms. 相似文献
955.
Dr. Phillip S. Grant Prof. Dr. Margaret A. Brimble 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(21):6367-6389
The cleavage of a C−C bond is a complexity generating process, which complements oxidation and cyclisation events in the biosynthesis of terpenoids. This process leads to increased structural diversity in a cluster of related secondary metabolites by modification of the parent carbocyclic core. In this review, we highlight the diversifying effect of C−C bond cleavage by examining the literature related to seco-labdanes—a class of diterpenoids arising from such C−C bond cleavage events. 相似文献
956.
Phillip James Dorsey Dominic Scalise Rebecca Schulman 《Angewandte Chemie (International ed. in English)》2021,60(1):338-344
Living systems can form and recover complex chemical patterns with precisely sized features in the ranges of tens or hundreds of microns. We show how designed reaction–diffusion processes can likewise produce precise patterns, termed attractor patterns, that reform their precise shape after being perturbed. We use oligonucleotide reaction networks, photolithography, and microfluidic delivery to form precisely controlled attractor patterns and study the responses of these patterns to different localized perturbations. Linear and “hill”‐shaped patterns formed and stabilized into shapes and at time scales consistent with reaction–diffusion models. When patterns were perturbed in particular locations with UV light, they reliably reformed their steady‐state profiles. Recovery also occurred after repeated perturbations. By designing the far‐from‐equilibrium dynamics of a chemical system, this study shows how it is possible to design spatial patterns of molecules that are sustained and regenerated by continually evolving towards a specific steady state configuration. 相似文献
957.
958.
Phillip Jackson Martin Diefenbach Ragampeta Srinivas Detlef Schroeder Helmut Schwarz 《ChemInform》2000,31(28):no-no
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 相似文献
959.
Dr. Phillip M. Danby Andrew Jeong Dr. Lyann Sim Dr. Ryan P. Sweeney Jacob F. Wardman Ryan Karimi Dr. Andreas Geissner Dr. Liam J. Worrall Prof. Dr. Jolene. P. Reid Prof. Dr. Natalie C. J. Strynadka Prof. Dr. Stephen G. Withers 《Angewandte Chemie (International ed. in English)》2023,62(21):e202301258
Suitably configured allyl ethers of unsaturated cyclitols act as substrates of β-glycosidases, reacting via allylic cation transition states. Incorporation of halogens at the vinylic position of these carbasugars, along with an activated leaving group, generates potent inactivators of β-glycosidases. Enzymatic turnover of these halogenated cyclitols (F, Cl, Br) displayed a counter-intuitive trend wherein the most electronegative substituents yielded the most labile pseudo-glycosidic linkages. Structures of complexes with the Sulfolobus β-glucosidase revealed similar enzyme-ligand interactions to those seen in complexes with a 2-fluorosugar inhibitor, the lone exception being displacement of tyrosine 322 from the active site by the halogen. Mutation of Y322 to Y322F largely abolished glycosidase activity, consistent with lost interactions at O5, but minimally affected (7-fold) rates of carbasugar hydrolysis, yielding a more selective enzyme for unsaturated cyclitol ether hydrolysis. 相似文献
960.
Dr. Mengting Liu Dr. Masao Ohashi Qingyang Zhou Dr. Jacob N. Sanders Prof. Erin P. McCauley Prof. Phillip Crews Prof. K. N. Houk Prof. Yi Tang 《Angewandte Chemie (International ed. in English)》2023,62(40):e202311266
We uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)-azonazine A from marine-derived Aspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo-(l -Trp-N-methyl-l -Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole-substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs. 相似文献