全文获取类型
收费全文 | 4728篇 |
免费 | 122篇 |
国内免费 | 29篇 |
专业分类
化学 | 3102篇 |
晶体学 | 15篇 |
力学 | 217篇 |
数学 | 799篇 |
物理学 | 746篇 |
出版年
2023年 | 22篇 |
2022年 | 74篇 |
2021年 | 76篇 |
2020年 | 61篇 |
2019年 | 71篇 |
2018年 | 57篇 |
2017年 | 59篇 |
2016年 | 128篇 |
2015年 | 115篇 |
2014年 | 147篇 |
2013年 | 260篇 |
2012年 | 327篇 |
2011年 | 389篇 |
2010年 | 203篇 |
2009年 | 218篇 |
2008年 | 281篇 |
2007年 | 288篇 |
2006年 | 298篇 |
2005年 | 286篇 |
2004年 | 226篇 |
2003年 | 221篇 |
2002年 | 201篇 |
2001年 | 68篇 |
2000年 | 73篇 |
1999年 | 45篇 |
1998年 | 60篇 |
1997年 | 65篇 |
1996年 | 62篇 |
1995年 | 44篇 |
1994年 | 53篇 |
1993年 | 34篇 |
1992年 | 28篇 |
1991年 | 24篇 |
1990年 | 22篇 |
1989年 | 18篇 |
1988年 | 20篇 |
1987年 | 17篇 |
1986年 | 11篇 |
1985年 | 26篇 |
1984年 | 19篇 |
1983年 | 13篇 |
1982年 | 14篇 |
1981年 | 12篇 |
1980年 | 18篇 |
1979年 | 22篇 |
1978年 | 19篇 |
1977年 | 11篇 |
1976年 | 14篇 |
1975年 | 11篇 |
1974年 | 9篇 |
排序方式: 共有4879条查询结果,搜索用时 15 毫秒
101.
Andr Maquestiau Philippe Meyrant Robert Flammang 《Journal of mass spectrometry : JMS》1982,17(2):96-101
Molecular or fragment ions can be prepared by a large variety of reactions in the field free regions of a mass spectrometer; these reactions involve spontaneous dissociation as well as collision induced excitation of singly or doubly charged precursors. Some typical examples show the different means which can lead to a given ion and how they can be studied by collisional activation. It also appears that in most cases the use of a triple sector (E/B/E) mass spectrometer facilitates these experiments as interfering artefacts are suppressed. 相似文献
102.
103.
104.
105.
106.
Malcher M Volodkin D Heurtault B André P Schaaf P Möhwald H Voegel JC Sokolowski A Ball V Boulmedais F Frisch B 《Langmuir : the ACS journal of surfaces and colloids》2008,24(18):10209-10215
A new antibacterial coating made of poly(L-lysine)/hyaluronic acid (PLL/HA) multilayer films and liposome aggregates loaded with silver ions was designed. Liposomes filled with an AgNO 3 solution were first aggregated by the addition of PLL in solution. The obtained micrometer-sized aggregates were then deposited on a PLL/HA multilayer film, playing the role of a spacer with the support. Finally, HA/PLL/HA capping layers were deposited on top of the architecture to form a composite AgNO 3 coating. Release of encapsulated AgNO 3 from this composite coating was followed and triggered upon temperature increase over the transition temperature of vesicles, found to be equal to 34 degrees C. After determination of the minimal inhibitory concentration (MIC) of AgNO 3 in solution, the antibacterial activity of the AgNO 3 coating was investigated against Escherichia coli. A 4-log reduction in the number of viable E. coli cells was observed after contact for 120 min with a 120 ng/cm (2) AgNO 3 coating. In comparison, no bactericidal activity was found for PLL/HA films previously dipped in an AgNO 3 solution and for PLL/HA films with liposome aggregates containing no AgNO 3 solution. The strong bactericidal effect could be linked to the diffusion of silver ions out of the AgNO 3 coating, leading to an important bactericidal concentration close to the membrane of the bacteria. A simple method to prepare antibacterial coatings loaded with a high and controlled amount of AgNO 3 is therefore proposed. This procedure is far superior to that soaking AgNO 3 or Ag nanoparticles into a coating. In principle, other small bactericidal chemicals like antibiotics could be encapsulated by this method. This study opens a new route to modify surfaces with small solutes that are not permeating phospholipid membranes below the phase transition temperature. 相似文献
107.
Matmour R De Cat I George SJ Adriaens W Leclère P Bomans PH Sommerdijk NA Gielen JC Christianen PC Heldens JT van Hest JC Löwik DW De Feyter S Meijer EW Schenning AP 《Journal of the American Chemical Society》2008,130(44):14576-14583
Two oligo(p-phenylenevinylene)-peptide hybrid amphiphiles have been synthesized using solid- and liquid-phase strategies. The amphiliphiles are composed of a pi-conjugated oligo(p-phenylenevinylene) trimer (OPV) which is coupled at either a glycinyl-alanyl-glycinyl-alanyl-glycine (GAGAG) silk-inspired beta-sheet or a glycinyl-alanyl-asparagyl-prolyl-asparagy-alanyl-alanyl-glycine (GANPNAAG) beta-turn forming oligopeptide sequence. The solid-phase strategy enables one to use longer peptides if strong acidic conditions are avoided, whereas the solution-phase coupling gives better yields. The study of the two-dimensional (2D) self-assembly of OPV-GAGAG by scanning tunneling microscopy (STM) at the submolecular level demonstrated the formation of bilayers in which the molecules are lying antiparallel in a beta-sheet conformation. In the case of OPV-GANPNAAG self-assembled monolayers could not be observed. Absorption, fluorescence, and circular dichroism studies showed that OPV-GAGAG and OPV-GANPNAAG are aggregated in a variety of organic solvents. In water cryogenic temperature transmission electron microscopy (cryo-TEM), atomic force microscopy (AFM), light scattering, and optical studies reveal that self-assembled nanofibers are formed in which the helical organization of the OPV segments is dictated by the peptide sequence. 相似文献
108.
[structures: see text] We studied the conformation of a series of primary amides in a solution of chloroform. Classical NMR tools such as dilution experiments, influence of DMSO, and 2D-NOESY, together with X-ray diffraction, were combined with an analysis of the difference of the chemical shift Deltadelta between the geminal amidic protons. This study was addressed in order to understand the conformation adopted by hydrazino acetamides 1a and 1b as model compounds for aza-beta3-peptides. In this manner, it was possible to show that the amidic group of these compounds acts as a H-bond donor and interacts with two different H-bond acceptors. We concluded that the hydrazinoturn, a specific bifurcated H-bond system observed in the solid state, is also the preferred conformation of hydrazino acetamides 1a and 1b in solution. Our results show that the short-range interaction with the N(alpha)-nitrogen lone pair not only stabilizes the C8 pseudocycle but could also contribute to the folding process of aza-beta3-peptides. In light of this, it could explain why aza-beta3-peptides develop a different H-bond network in comparison to their isosteric beta3-peptides analogues. Our work is in keeping with the recent interest of hydrazino peptides as an extension of the beta-peptide concept. 相似文献
109.
Sixteen pyrrolo[3,2- e][1,4]diazepin-2-ones 1 were synthesized in 4-5 steps and 5-48% overall yields from 4-oxoproline 8 by a route featuring a diastereoselective Pictet-Spengler reaction to close the seven-membered diazepinone ring. Crystallographic analysis of pyrrolo[3,2- e][1,4]diazepin-2-one 1b by X-ray diffraction demonstrated that the alpha-amino acid residue adopted dihedral angle geometry similar to an ideal gamma-turn, illustrating the potential for employing these novel heterocycles as peptide turn mimics. 相似文献
110.
The use of a powerful aminobenzannulation reaction has been applied for the synthesis of amino-substituted quinolines, dibenzofurans, and carbazoles. The precursors are heterocycles bearing a methyl ketone group ortho to an internal alkyne. They are commercially available or can be obtained in three to four classical and efficient reactions: Vilsmeier-Haack, Sonogashira (diversity point), Grignard, and Ley's oxidation. Upon aminobenzannulation reaction-classical conditions being pyrrolidine neat or in a solvent and 4 A MS-an interesting range of disubstituted quinolines, dibenzofurans, and carbazoles are obtained along with enamine formation in some cases. The reaction is useful since meta-substituted heterocycles are produced and also differs from classical heterocyclic methods which go through closure at the heteroatom-containing ring instead of benzene ring formation. 相似文献