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261.
Lorne Tallet Emilie Frisch Mgane Bornerie Claire Medemblik Benoît Frisch Philippe Lavalle Gilles Guichard Cline Douat Antoine Kichler 《Molecules (Basel, Switzerland)》2022,27(5)
There is an urgent need to develop new therapeutic strategies to fight the emergence of multidrug resistant bacteria. Many antimicrobial peptides (AMPs) have been identified and characterized, but clinical translation has been limited partly due to their structural instability and degradability in physiological environments. The use of unnatural backbones leading to foldamers can generate peptidomimetics with improved properties and conformational stability. We recently reported the successful design of urea-based eukaryotic cell-penetrating foldamers (CPFs). Since cell-penetrating peptides and AMPs generally share many common features, we prepared new sequences derived from CPFs by varying the distribution of histidine- and arginine-type residues at the surface of the oligourea helix, and evaluated their activity on both Gram-positive and Gram-negative bacteria as well as on fungi. In addition, we prepared and tested new amphiphilic block cofoldamers consisting of an oligourea and a peptide segment whereby polar and charged residues are located in the peptide segment and more hydrophobic residues in the oligourea segment. Several foldamer sequences were found to display potent antibacterial activities even in the presence of 50% serum. Importantly, we show that these urea-based foldamers also possess promising antifungal properties. 相似文献
262.
Delphine Catel Olivier Payen Floris Chevallier Florence Mongin Philippe C. Gros 《Tetrahedron》2012,68(21):4018-4028
Butyl and dibutylmagnesiates incorporating chiral ligands have been prepared and their reactivity studied. The reagents were efficient to promote the clean bromine–magnesium exchange of azinyl bromides at room temperature and subsequent reaction with aldehydes affording pyridylcarbinols. (R,R)-TADDOL-based dibutylmagnesiate was the best reagent leading to acceptable to good enantioselectivities, depending on the substrate and on the aldehyde substitution. This is the first example of enantioselective addition of in situ generated pyridylmagnesiate to carbonyl electrophiles. 相似文献
263.
ZDM – Mathematics Education - Our article aims to show how illuminating mathematical work as a concept from didactics of mathematics is useful in understanding issues relating to proving and... 相似文献
264.
Improvements for ground-based remote sensing of atmospheric aerosol properties by additional polarimetric measurements 总被引:1,自引:0,他引:1
Zhengqiang Li Philippe Goloub Oleg Dubovik Luc Blarel Wenxing Zhang Thierry Podvin Alexander Sinyuk Mikhail Sorokin Hongbin Chen Brent Holben Didier Tanr Marius Canini Jean-Pierre Buis 《Journal of Quantitative Spectroscopy & Radiative Transfer》2009,110(17):1954-1961
We discuss the improvements in the aerosol properties characterization resulting from the additional multi-wavelength polarization measurements measured by a new CIMEL polarized sun/sky-photometer, CE318-DP. In order to process direct-sun, sky and polarization measurements in a wide spectral range (340–1640 nm), we developed new calibration methods and strategies, e.g. using the Langley plot method to calibrate both direct-sun irradiance and sky radiance, as well as combining laboratory facilities with a vicarious method to calibrate the polarized sky measurements. For studying the impact of new polarimetric measurements on the retrievals of aerosol properties, we have processed an extensive record of field measurements using an updated Dubovik and King retrieval algorithm [Dubovik O, Sinyuk A, Lapyonok T, Holben BN, Mishchenko MI, et al. Application of spheroid models to account for aerosol particle nonsphericity in remote sensing of desert dust. J Geophys Res 2006;111:D11208.]. A preliminary analysis shows that adding polarization in the inversion can reduce possible errors (notably for about 30% of our field cases) in the fine mode size distribution, real part of refractive index and particle shape parameter retrievals, especially for small particles. 相似文献
265.
Lana Mara Rodrigues dos Santos Philippe Michelon Marcos Nereu Arenales Ricardo Henrique Silva Santos 《Annals of Operations Research》2011,190(1):165-180
In this article we propose a 0-1 optimization model to determine a crop rotation schedule for each plot in a cropping area.
The rotations have the same duration in all the plots and the crops are selected to maximize plot occupation. The crops may
have different production times and planting dates. The problem includes planting constraints for adjacent plots and also
for sequences of crops in the rotations. Moreover, cultivating crops for green manuring and fallow periods are scheduled into
each plot. As the model has, in general, a great number of constraints and variables, we propose a heuristics based on column
generation. To evaluate the performance of the model and the method, computational experiments using real-world data were
performed. The solutions obtained indicate that the method generates good results. 相似文献
266.
267.
Emmanuel Philippe 《Comptes Rendus Mathematique》2011,349(21-22):1183-1186
In this Note we give an explicit formula for the length of the shortest geodesic loop for hyperbolic spheres with three singularities of order greater than 3. 相似文献
268.
Mechanical properties of anion exchange membranes by combination of tensile stress–strain tests and dynamic mechanical analysis
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Riccardo Narducci J.‐F. Chailan A. Fahs Luca Pasquini Maria Luisa Di Vona Philippe Knauth 《Journal of Polymer Science.Polymer Physics》2016,54(12):1180-1187
The thermomechanical properties of anion exchange polymers based on polysulfone (PSU) quaternized with trimethylamine (TMA) or 1,4‐diazabicyclo[2.2.2]octane (DABCO) and containing hydroxide or chloride anions by tensile stress–strain tests and dynamic mechanical analysis (DMA) have been determined. The reported mechanical properties included the Young's modulus, tensile strength, and elongation at break from tensile tests and the storage and loss modulus and glass transition temperature from DMA. The anion exchange membranes behaved as stiff polymers with Young's modulus in the order of 1 GPa, relatively with high strength (about 30 MPa) and low elongation at break (around 10%) was observed. Tensile tests were also made with membranes exchanged with hydrogen‐carbonate and carbonate anions to control the absence of important carbonation of the OH form. The glass transition temperatures were of the order of 150 °C (PSU‐TMA) or 200 °C (PSU‐DABCO) for the hydroxide form, confirmed by differential scanning calorimetry; they increase further by about 50 K, when hydroxide ions are replaced by chloride. This result and the increase of the storage modulus could be interpreted by the higher hydration of hydroxide ions and the plasticizing effect of water, which reduced the Van der Waals interactions between the macromolecular chains. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54, 1180–1187 相似文献
269.