Radical C?H Functionalization of Heteroarenes under Electrochemical Control

Electrochemical reactions are shown to be effective for the C H functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C H functionalization of a series of heterocycles of interest in medicinal chemistry.     

Inversion of analytically perturbed linear operators that are singular at the origin

Let H and K be Hilbert spaces and for each z∈C let A(z)∈L(H,K) be a bounded but not necessarily compact linear map with A(z) analytic on a region |z|<a. If A(0) is singular we find conditions under which A⁻¹(z) is well defined on some region 0<|z|<b by a convergent Laurent series with a finite order pole at the origin. We show that by changing to a standard Sobolev topology the method extends to closed unbounded linear operators and also that it can be used in Banach spaces where complementation of certain closed subspaces is possible. Our method is illustrated with several key examples.²     

Synthesis of 2-alkyl- and aryl-3-ethoxycarbonyl-2,5-dihydrofurans through gold-catalyzed intramolecular hydroalkoxylation

Treatment of a wide range of functionalized hydroxyallenic esters with 5 mol % Ph(3)PAuCl and 5 mol % AgOTf in CH(2)Cl(2) at 25 °C for 1 h produced selectively 2-alkyl- and aryl-3-ethoxycarbonyl-2,5-dihydrofurans in good to excellent yield through intramolecular hydroalkoxylation by a 5-endo mode.     

Towards molecular imaging and treatment of disease with radionuclides: the role of inorganic chemistry

Molecular imaging and radiotherapy using radionuclides is a rapidly expanding field of medicine and medical research. This article highlights the development of the role of inorganic chemistry in designing and producing the radiopharmaceuticals on which this interdisciplinary science depends.     

The role of rebound spikes in the maintenance of self-sustained neural spiking activity

Nonlinear Dynamics - In general, the mechanisms that maintain the activity of neural systems after a triggering stimulus has been removed are not well understood. Different mechanisms involving at...