Microstructure of vinyl acetate–butyl acrylate copolymers studied by 13C-NMR spectroscopy: Influence of emulsion polymerization process

The compositions and sequence distributions of vinyl acetate–butyl acrylate copolymers obtained with batch and semicontinuous emulsion polymerizations have been studied by ¹H and ¹³C NMR. The batch process gives heterogeneous copolymers while with the semicontinuous one the sequence distribution is statistical. These differences in sequence distributions have been related to the physical properties of the copolymers.     

Flash photolysis studies of the reaction of NH2 radicals with NO

The kinetics of the reaction NH₂ + NO → N₂ + H₂O were studied, using a conventional flash photolysis system. A value of k₁ = (1.1 ± 0.2) × 10¹⁰ & mole^?1 s^?1 was obtained at room temperature and in the pressure range 2–700 torr in the presence of nitrogen. A slight negative temperature coefficient was observed between 300 and 500 K, equivalent to a negative activation energy of 1.05 ± 0.2 kcal mole^?1.     

The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins

TIR-domain-containing adapter-inducing interferon-β (TRIF) is an innate immune protein that serves as an adaptor for multiple cellular signalling outcomes in the context of infection. TRIF is activated via ligation of Toll-like receptors 3 and 4. One outcome of TRIF-directed signalling is the activation of the programmed cell death pathway necroptosis, which is governed by interactions between proteins that contain a RIP Homotypic Interaction Motif (RHIM). TRIF contains a RHIM sequence and can interact with receptor interacting protein kinases 1 (RIPK1) and 3 (RIPK3) to initiate necroptosis. Here, we demonstrate that the RHIM of TRIF is amyloidogenic and supports the formation of homomeric TRIF-containing fibrils. We show that the core tetrad sequence within the RHIM governs the supramolecular organisation of TRIF amyloid assemblies, although the stable amyloid core of TRIF amyloid fibrils comprises a much larger region than the conserved RHIM only. We provide evidence that RHIMs of TRIF, RIPK1 and RIPK3 interact directly to form heteromeric structures and that these TRIF-containing hetero-assemblies display altered and emergent properties that likely underlie necroptosis signalling in response to Toll-like receptor activation.     

Synthesis of Jasminaldehyde by Solid-Liquid Phase Transfer Catalysis Without Solvent,Under Microwave Irradiation

α-n-amylcinnamaldehyde (jasminaldehyde) was obtained with 82 % yield by solid-liquid phase transfer catalysis without solvent within 3 days at room temperature. By use of domestic microwave irradiation, the same yield was obtained within 1 minute at a power of 600 W.     

On the rate of convergence for central limit theorems of sojourn times of Gaussian fields

The aim of this paper is to control the rate of convergence for central limit theorems of sojourn times of Gaussian fields in both cases: the fixed and the moving level. Our main tools are the Malliavin calculus and the Stein method, developed by Nualart, Peccati and Nourdin. We also extend some results of Berman to the multidimensional case.     

Regioselective Hydrolysis of Cocaine and A Convenient Acylation Procedure by Benzoylecgonine

Regioselective hydrolysis of cocaine led, according to the reaction conditions, either to benzoylecgonine or to ecgonine methyl ester. Acylation with benzoylecgonine was readily achieved when benzotriazolyloxytrisdimethylamino-phosphonium (BOP) was used as a coupling agent.