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121.
Peterson RL Himes RA Kotani H Suenobu T Tian L Siegler MA Solomon EI Fukuzumi S Karlin KD 《Journal of the American Chemical Society》2011,133(6):1702-1705
The new cupric superoxo complex [LCu(II)(O(2)(?-))](+), which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases. 相似文献
122.
Zhang Q Kang M Peterson RD Feigon J 《Journal of the American Chemical Society》2011,133(14):5190-5193
Riboswitches regulate gene expression via specific recognition of cognate metabolites by their aptamer domains, which fold into stable conformations upon ligand binding. However, the recently reported solution and crystal structures of the Bacillus subtilis preQ(1) riboswitch aptamer show small but significant differences, suggesting that there may be conformational heterogeneity in the ligand-bound state. We present a structural and dynamic characterization of this aptamer by solution NMR spectroscopy. The aptamer-preQ(1) complex is intrinsically flexible in solution, with two regions that undergo motions on different time scales. Three residues move in concert on the micro-to-millisecond time scale and may serve as the lid of the preQ(1)-binding pocket. Several Ca(2+) ions are present in the crystal structure, one of which binds with an affinity of 47 ± 2 μM in solution to a site that is formed only upon ligand binding. Addition of Ca(2+) to the aptamer-preQ(1) complex in solution results in conformational changes that account for the differences between the solution and crystal structures. Remarkably, the Ca(2+) ions present in the crystal structure, which were proposed to be important for folding and ligand recognition, are not required for either in solution. 相似文献
123.
124.
2-Bromo-6-lithiopyridine adds stereoselectively to the β-face of 1,2;5,6-di-O-isopropylidene-α-D-glucofuranos-3-ulose (2) to provide compound 5 in 50% yield as a single diastereomer. Compound 5 can be coupled to form novel C2-symmetric 2,2′-bipyridine 7, the first example of a C2-symmetric bipyridine that derives chirality from glucose. 相似文献
125.
126.
Dr. Su‐Young Moon Emmanuel Proussaloglou Gregory W. Peterson Dr. Jared B. DeCoste Morgan G. Hall Dr. Ashlee J. Howarth Prof. Joseph T. Hupp Prof. Omar K. Farha 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(42):14864-14868
Owing to their high surface area, periodic distribution of metal sites, and water stability, zirconium‐based metal–organic frameworks (Zr6‐MOFs) have shown promising activity for the hydrolysis of nerve agents GD and VX, as well as the simulant, dimethyl 4‐nitrophenylphosphate (DMNP), in buffered solutions. A hurdle to using MOFs for this application is the current need for a buffer solution. Here the destruction of the simulant DMNP, as well as the chemical warfare agents (GD and VX) through hydrolysis using a MOF catalyst mixed with a non‐volatile, water‐insoluble, heterogeneous buffer is reported. The hydrolysis of the simulant and nerve agents in the presence of the heterogeneous buffer was fast and effective. 相似文献
127.
Deyonker NJ Peterson KA Steyl G Wilson AK Cundari TR 《The journal of physical chemistry. A》2007,111(44):11269-11277
The correlation consistent Composite Approach (ccCA), which has been shown to achieve chemical accuracy (+/-1 kcal mol-1) for a large benchmark set of main group and s-block metal compounds, is used to compute enthalpies of formation for a set of 17 3d transition metal species. The training set includes a variety of metals, ligands, and bonding types. Using the correlation consistent basis sets for the 3d transition metals, we find that gas-phase enthalpies of formation can be efficiently calculated for inorganic and organometallic molecules with ccCA. However, until the reliability of gas-phase transition metal thermochemistry is improved, both experimentally and theoretically, a large experimental training set where uncertainties are near +/-1 kcal mol-1 (akin to commonly used main group benchmarking sets) remains an ambitious goal. For now, an average deviation of +/-3 kcal mol-1 appears to be the initial goal of "chemical accuracy" for ab initio transition metal model chemistries. The ccCA is also compared to a more robust but relatively expensive composite approach primarily utilizing large basis set coupled cluster computations. For a smaller training set of eight molecules, ccCA has a mean absolute deviation (MAD) of 3.4 kcal mol-1 versus the large basis set coupled-cluster-based model chemistry, which has a MAD of 3.1 kcal mol-1. However, the agreement for transition metal complexes is more system dependent than observed in previous benchmark studies of composite methods and main group compounds. 相似文献
128.
Gregory W. Peterson John J. Mahle Jared B. DeCoste Wesley O. Gordon Joseph A. Rossin 《Angewandte Chemie (International ed. in English)》2016,55(21):6235-6238
Here we discuss the removal of nitrogen dioxide, an important toxic industrial chemical and pollutant, from air using the MOF UiO‐66‐NH2. The amine group is found to substantially aid in the removal, resulting in unprecedented removal capacities upwards of 1.4 g of NO2 /g of MOF. Furthermore, whereas NO2 typically generates substantial quantities of NO on sorbents, the amount generated by UiO‐66‐NH2 is significantly reduced. Of particular significance is the formation of a diazonium ion on the aromatic ring of the MOF, and the potential reduction of NO2 to molecular nitrogen. 相似文献
129.
Junjie Zhao Dennis T. Lee Robert W. Yaga Morgan G. Hall Heather F. Barton Ian R. Woodward Christopher J. Oldham Howard J. Walls Gregory W. Peterson Prof. Gregory N. Parsons 《Angewandte Chemie (International ed. in English)》2016,55(42):13224-13228
The threat associated with chemical warfare agents (CWAs) motivates the development of new materials to provide enhanced protection with a reduced burden. Metal–organic frame‐works (MOFs) have recently been shown as highly effective catalysts for detoxifying CWAs, but challenges still remain for integrating MOFs into functional filter media and/or protective garments. Herein, we report a series of MOF–nanofiber kebab structures for fast degradation of CWAs. We found TiO2 coatings deposited via atomic layer deposition (ALD) onto polyamide‐6 nanofibers enable the formation of conformal Zr‐based MOF thin films including UiO‐66, UiO‐66‐NH2, and UiO‐67. Cross‐sectional TEM images show that these MOF crystals nucleate and grow directly on and around the nanofibers, with strong attachment to the substrates. These MOF‐functionalized nanofibers exhibit excellent reactivity for detoxifying CWAs. The half‐lives of a CWA simulant compound and nerve agent soman (GD) are as short as 7.3 min and 2.3 min, respectively. These results therefore provide the earliest report of MOF–nanofiber textile composites capable of ultra‐fast degradation of CWAs. 相似文献
130.
Dixon DA Wang TH Grant DJ Peterson KA Christe KO Schrobilgen GJ 《Inorganic chemistry》2007,46(23):10016-10021
Atomization energies at 0 K and heats of formation at 0 and 298 K are predicted for KrF+, KrF-, KrF2, KrF3+, KrF4, KrF5+, and KrF6 from coupled-cluster theory (CCSD(T)) calculations with effective core potential correlation-consistent basis sets for krypton. To achieve near chemical accuracy (+/-1 kcal/mol), three corrections were added to the complete basis set binding energies based on frozen core coupled-cluster theory energies: a correction for core-valence effects, a correction for scalar relativistic effects, and a correction for first-order atomic spin-orbit effects. Vibrational zero point energies were computed at the coupled-cluster level of theory. The calculated value for the heat of formation of KrF2 is in excellent agreement with the experimental value. Contrary to the analogous xenon fluorides, KrF2, KrF4, and KrF6 are predicted to be thermodynamically unstable with respect to loss of F2. An analysis of the energetics of KrF4 and KrF6 with respect to fluorine atom loss together with calculations of the transition states for the intramolecular loss of F2 show that fluorine atom loss is the limiting factor determining the kinetic stabilities of these molecules. Whereas KrF4 possesses a marginal energy barrier of 10 kcal/mol toward fluorine atom loss and might be stable at moderately low temperatures, the corresponding barrier in KrF6 is only 0.9 kcal/mol, suggesting that it could exist only at very low temperatures. Although the simultaneous reactions of either two or four fluorine atoms with KrF2 to give KrF4 or KrF6, respectively, are exothermic, they do not represent feasible synthetic approaches because the attack of the fluorine ligands of KrF2 by the fluorine atoms, resulting in F2 abstraction, is thermodynamically favored over oxidative fluorination of the krypton central atom. Therefore, KrF6 could exist only at very low temperatures, and even the preparation of KrF4 will be extremely difficult. 相似文献