全文获取类型
收费全文 | 28431篇 |
免费 | 696篇 |
国内免费 | 230篇 |
专业分类
化学 | 19301篇 |
晶体学 | 128篇 |
力学 | 648篇 |
综合类 | 1篇 |
数学 | 5385篇 |
物理学 | 3894篇 |
出版年
2022年 | 183篇 |
2021年 | 276篇 |
2020年 | 347篇 |
2019年 | 313篇 |
2018年 | 276篇 |
2017年 | 292篇 |
2016年 | 601篇 |
2015年 | 621篇 |
2014年 | 660篇 |
2013年 | 1406篇 |
2012年 | 1407篇 |
2011年 | 1707篇 |
2010年 | 953篇 |
2009年 | 815篇 |
2008年 | 1468篇 |
2007年 | 1469篇 |
2006年 | 1553篇 |
2005年 | 1394篇 |
2004年 | 1327篇 |
2003年 | 1105篇 |
2002年 | 1046篇 |
2001年 | 453篇 |
2000年 | 408篇 |
1999年 | 395篇 |
1998年 | 385篇 |
1997年 | 433篇 |
1996年 | 398篇 |
1995年 | 360篇 |
1994年 | 391篇 |
1993年 | 345篇 |
1992年 | 320篇 |
1991年 | 320篇 |
1990年 | 278篇 |
1989年 | 280篇 |
1988年 | 260篇 |
1987年 | 218篇 |
1986年 | 246篇 |
1985年 | 361篇 |
1984年 | 370篇 |
1983年 | 315篇 |
1982年 | 348篇 |
1981年 | 317篇 |
1980年 | 338篇 |
1979年 | 270篇 |
1978年 | 300篇 |
1977年 | 279篇 |
1976年 | 223篇 |
1975年 | 190篇 |
1974年 | 195篇 |
1973年 | 165篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
122.
123.
The synthesis of a series of tetra‐ and pentadentate bispidine‐type ligands (bispidine=3,7‐diazabicyclo[3.3.1]nonane) – tetradentate ligands are donor‐substituted at C(2) and C(4), pentadentate ligands have an additional donor at N(3) or N(7), with pyridine, 2‐methylpyridine, or quinoline donor moieties – and of their CuII complexes are reported, together with single‐crystal structural analyses and solution studies (electrochemistry, electronic and EPR spectroscopy). Depending on the ligand geometry and on the co‐ligands (solvent or counter anion), there are various structural forms (pseudo‐Jahn–Teller elongation along all three molecular axes), and the structural data are correlated with the spectroscopic and electrochemical parameters. 相似文献
124.
Peter Checkland 《The Journal of the Operational Research Society》1985,36(9):821-831
Rational intervention in human affairs, if it is to constitute not only action but also research, so that future interventions may be made more effective, needs a well-defined methodological framework. Soft systems methodology (S.S.M.) provides one such framework. S.S.M. is doubly systemic: it is itself a learning system, and within that system it uses systems models, models of human activity systems. It accepts that such models are not models of parts of the real world, only models of ways of perceiving the real world, that is to say, models relevant to debate about ‘reality’ (one man's ‘terrorism’ is another's ‘freedom fighting’).S.S.M. is here illustrated by means of an account of a systems study of change in the information function of a sophisticated science-based company. The study is described from the point of view of a professional analyst who was helping a team of three managers carry out the study. The course of the study is described, and a separate commentary relates its activity to the seven stages of S.S.M. The study involved three cycles round stages 2–3–4–5 of S.S.M., the stages in which models of relevant human activity systems are built and compared with the real world in order to construct a rich debate about changes whose introduction in the problem situation world be both (systemically) desirable and (culturally) feasible. 相似文献
125.
Svein G. Dahl Peter A. Kollman Shashidhar N. Rao U. Chandra Singh 《Journal of computer-aided molecular design》1992,6(3):207-222
Summary The side-chain conformations of psychoactive phenothiazine drugs in crystals are different from those of biologically inactive ring sulfoxide metabolites. This study examines the potential energies, molecular conformations and electrostatic potentials in chlorpromazine, levomepromazine (methotrimeprazine), their sulfoxide metabolites and methoxypromazine. The purpose of the study was to examine the significance of the different crystal conformations of active and inactive phenothiazine derivatives, and to determine why phenothiazine drugs lose most of their biological activity by sulfoxidation. Quantum mechanics and molecular mechanics calculations demonstrated that conformations with the side chain folded over the ring structure had lowest potential energy in vacuo, both in the drugs and in the sulfoxide metabolites. In the sulfoxides, side chain conformations corresponding to the crystal structure of chlorpromazine sulfoxide were characterized by stronger negative electrostatic potentials around the ring system than in the parent drugs. This may weaken the electrostatic interaction of sulfoxide metabolites with negatively charged domains in dopamine receptors, and cause the sulfoxides to be virtually inactive in dopamine receptor binding and related pharmacological tests. 相似文献
126.
Six different hierarchal clustering algorithms were used to cluster eleven sets of compounds for which associated property data were available. The effectiveness of the clustering in each case was assessed by inspection of the resulting tree diagram representing the classification and by the utility of the classification for molecular property prediction. The best predictions were generally obtained by using the algorithm proposed by Ward while the widely-used nearest neighbour algorithm performed very badly. Unstandardised data gave better results than standardised data although the difference was less when structurally related, rather than structurally disparate, groups of compounds were tested. 相似文献
127.
We have carried out an ab initio self-consistent-field molecular orbital study of the structures and relative bond strengths of some monoamine derivatives of cubane, azacubane, and 1,3-diazacubane. Our focus has been on the effect of the NH2 group on the strengths of the endocyclic strained bonds in these molecules, and, in particular, on the conformation dependence of this effect. Our results show a consistent bond-weakening observed in one [and only one] C-C or C-N bond adjacent to the site of NH2 substitution. We find that the particular bond that is weakened is in all cases essentially coplanar with the C-NH2 bond and the position of the most negative electrostatic potential of the amine nitrogen. This direction-specific bond-weakening is viewed as an example of the anomeric effect. 相似文献
128.
A new approach to the evaluation of two-electron repulsion integrals over contracted Gaussian basis functions is developed. The new scheme encompasses 20 distinct, but interrelated, paths from simple shell-quartet parameters to the target integrals, and, for any given integral class, the path requiring the fewest floating-point operations (FLOPS ) is that used. Both theoretical (FLOP counting) and practical (CPU timing) measures indicate that the method represents a substantial improvement over the HGP algorithm. 相似文献
129.
Rudolf O. Duthaler Peter Herold Susanne Wyler-Helfer Martin Riediker 《Helvetica chimica acta》1990,73(3):659-673
Chloro(cyclopentadienyl)bis(1,2:5,6-di-O-isopropylidene-α-D -glucofuranos-3-O-yl)titanium ( 1 ) is used for the transmetallation of Li-enolates obtained from propionyl derivatives. While such Ti-enolates of ketones and hydrazones appear to be unreactive, the (E)enolate 13 of 2,6-dimethylphenyl propionate ( 11 ) adds to the re-side of aldehydes, affording various syn-aldols 14 with high dia- and enantioselectivity (92–97% ds, 91–97% ee, cf. Scheme 2 and Table 1). Racemic syn-aldols (±)- 14 are obtained analogously from the achiral bis(2-propyloxy)-Ti-enolate 15 (Scheme 2 and Table 2). In contrast to the unstable Li-enolate 10 , the Ti-enolates 13 and 15 isomerize at ?30°, presumably to the thermodynamically more stable (Z)-enolates (Scheme 4), While the diastereoselectivity of the achiral enolate 15 is lost upon this equilibration, the chiral (Z)-enolate 27 quite unexpectedly affords anti-aldols 12 of high optical purity (94–98% ec) and, in most cases, with acceptable-to-good diastereoselectivity (82–90% ds). Notable exceptions are branched unsaturated and aromatic aldehydes which form a greater proportion of synepimers of moderate optical purity (Scheme 5 and Table 3). Consistent with these findings, re-facial-and ami -selective aldol-addition is also exhibited by the (Z)-configurated Ti-enolate 22 of N-propionyl-oxazolidi-none 19 (Scheme 3). 相似文献
130.