Fabrication of interdigitated high-performance zinc oxide nanowire modified electrodes for glucose sensing

Diabetes is a metabolic disease with a prolonged elevated level of glucose in the blood leads to long-term complications and increases the chances for cardiovascular diseases. The present study describes the fabrication of a ZnO nanowire (NW)-modified interdigitated electrode (IDE) to monitor the level of blood glucose. A silver IDE was generated by wet etching-assisted conventional lithography, with a gap between adjacent electrodes of 98.80 μm. The ZnO-based thin films and NWs were amended by sol–gel and hydrothermal routes. High-quality crystalline and c-axis orientated ZnO thin films were observed by XRD analyses. The ZnO thin film was annealed for 1, 3 and 5 h, yielding a good-quality crystallite with sizes of 50, 100 and 110 nm, and the band gaps were measured as 3.26, 3.20 and 3.17 eV, respectively. Furthermore, a flower-modeled NW was obtained with the lowest diameter of 21 nm. Our designed ZnO NW-modified IDE was shown to have a detection limit as low as 0.03 mg/dL (correlation coefficient = 0.98952) of glucose with a low response time of 3 s, perform better than commercial glucose meter, suitable to instantly monitor the glucose level of diabetes patients. This study demonstrated the high performance of NW-mediated IDEs for glucose sensing as alternative to current glucose sensors.     

Bis-spirochromanones as potent inhibitors of Mycobacterium tuberculosis: synthesis and biological evaluation

Molecular Diversity - On the basis of reported antimycobacterial property of chroman-4-one pharmacophore, a series of chemically modified bis-spirochromanones were synthesized starting from...     

Aptamer-based determination of ATP by using a functionalized impedimetric nanosensor and mediation by a triangular junction transducer

Microchimica Acta - The authors describe an impedimetric nanosensor for aptamer-mediated detection of ATP. A triangular junction of polysilicon substrate is used as a transducer. The aptamer was...     

The First Recyclable,Nanocrystalline CdS Thin Film Mediated Eco‐benign Synthesis Of Hantzsch 1, 4 Dihyropyridines, 1, 8‐Dioxodecahydroacridine and Polyhydroquinolines derivatives

In the present study, we report a recyclable, nanocrystalline CdS thin film mediated efficient one‐pot, three component synthesis of Hantzsch 1, 4 Dihydropyridine in good yields. The catalyst is also effective for the efficient synthesis of Polyhydroquinoline and 1, 8‐dioxodecahydroacridine derivatives in good to excellent yields. The CdS thin film catalyst was prepared by chemical bath deposition (CBD) technique. The cadmium sulphide thin film was characterized by powder XRD and FT‐IR studies. The average crystallite size (D) was calculated from powder XRD by using Scherrer formula and SEM analysis. The elemental composition of the CdS thin film was established by EDS analysis. The effect of temperature, substituent's, catalyst loading and mole ratio on the reaction was also studied. All the products were thoroughly characterized by ¹H‐NMR, ¹³C‐NMR, FT‐IR, Mass spectral and CHN analysis. A plausible mechanism for the CdS thin film catalyzed synthesis of 1, 4 DHP's is proposed. The heterogeneous catalyst could be easily recovered from the reaction mixture and successively reused at least five times without loss of activity.     

Synthesis of benzosuberone-tethered spirooxindoles: 1-3-dipolar cycloaddition of azomethine ylides and arylidene benzosuberones

Molecular Diversity - Expedient synthesis of benzosuberone-tethered spirooxindoles was accomplished by a three-component 1,3-dipolar cycloaddition reaction between azomethine ylide (generated in...     

Subshell Resolved Measurements of Single Electron Capture in Slow Ne7+–Helium Collisions

Hyperfine Interactions - We have performed drying-humectation cyclical processes (CEBELCOR) on eight A36 low carbon steel coupons in NaCl solutions containing 1×10?2 M and...     

A mild,efficient and improved protocol for the friedländer synthesis of quinolines using lewis acidic ionic liquid

Lewis acidic ionic liquid is shown to be for the first time an excellent medium and efficient catalyst for the synthesis of quinolines at room temperature from o‐amino aromatic carbonyls and ketones containing active methylene group.     

Asymmetric methallylboration of prochiral aldehydes with methallyldiisopinocampheylborane·synthesis of 2-methyl-1-alken-4-ols in ≥ 90% enantiomeric purities

Methallyldiisopinocampheylborane, on condensation with aldehydes, provides 2-methyl-1-alken-4-ols in ≥ 90% enantiomeric purities.     

Chiral and Achiral 1,3,4‐Oxadiazolophanes: A New Class of Cyclophanes in Supramolecular Chemistry

The synthesis of novel oxadiazolophanes with chiral (S)‐BINOL and methylene bis‐naphthyl as building blocks has been achieved by one pot reaction with simple and mild condition.