Preparation and evaluation of <Superscript>131</Superscript>I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer

Here we reported the radiolabeling and evaluation of a novel ¹³¹I-radiolabeled quercetin for the treatment of dedifferentiated thyroid cancers. The human thyroid cancer cell lines (FTC-133, TT and DRO) experienced much higher uptake of ¹³¹I-quercetin as compared to the free ¹³¹I. And the proliferation inhibition rate of ¹³¹I-quercetin on in vitro DRO cell line was 86.87 ± 7.15%. Biodistribution and SPECT analysis demonstrated that the injected radioactivity mainly accumulated in tumors. The tumor volume in the treatment group was dramatically inhibited in comparison with the control group.     

Structural,magnetic and optical properties of vanadium doped zinc oxide: Systematic first-principles investigations

The electronic structural, magnetic and optical properties of pure and V-doped ZnO are investigated by first-principles calculations based on the density functional theory. With the introduction of V atoms, the spin-splitting near the Fermi level leads to a net magnetic moment of the system. A significant possibility of room temperature ferromagnetism (RTFM) originated from the Ruderman–Kittel–Kassuya–Yosida (RKKY) exchange is predicted. Oxygen vacancy is positive to enhance the ferromagnetism while zinc vacancy is negative. With respect to the optical properties, the presence of V atoms was found to have an obvious influence on the transmittivity, especially in the low energy region. A slight V-doping can keep a high optical transmission and smoothly modulate the optical bandgap.     

Contact mechanics modeling of piezo-actuated stick-slip microdrives

This paper draws a line from early attempts of modeling stick-slip microdrives to open questions from today’s research. As a basis, it contains a collection of substantial investigations on piezo-actuated stick-slip microdrives for nanomanipulation purposes. Friction models showing special characteristics and their mathematical representations are reviewed. It is found that the working properties of stick-slip drives strongly depend on friction characteristics of the contact points between the guiding elements, which is known for years. However, numerous publications in the field of friction and remaining problems — which cannot be explained by known friction models — indicate that there is a demand for even more friction-related research.Former attempts to model stick-slip drives are based on the so-called LuGre friction model, which is shortly presented. An empirical model called CEIM is also analyzed. It is an adaption of the elastoplastic model. The latter can cover not only the phenomenon “0-amplitude’ (described by the authors in recent publications), but also stick-slip based force generation scenarios. Nevertheless, interesting friction characteristics such as the generation of μN forces with stick-slip drives, which are already proven, cannot be covered by known friction models. It is pointed out which characteristics have to be considered.     

CoNi-embedded nitrogen-enriched porous carbon framework for long-life lithium–sulfur batteries

Journal of Solid State Electrochemistry - Metal–organic framework (MOF) derivatives are excellent energy storage devices such as lithium–sulfur batteries. Here, a bimetallic...     

External perturbation manifested system size resonance in a mesoscopic hormone signaling model

In mesoscopic reaction systems that contain only finite number of reactants, molecular fluctuation (or the so called internal noise), which can be characterized by the system size, plays an important role in nonlinear systems. In this work, the effect of internal noise is studied in a mesoscopic hormone signaling model with the presence of external perturbations (noise or signal). Simulation results reveal that the internal noise can play a constructive role to optimize the regularity of the noise induced internal signal only when external perturbation is present. This is a novel external perturbations induced system size resonance, which indicates that in complex mesoscopic systems, the system can automatically avoid the destructive environmental effects by tuning its size. Such kind of nontrivial cooperative effect may attribute to the fact that external perturbations broadened the regulation scope of the key mutual feedback. Therefore, current finding is of practical significance for similar physiological systems where the intercellular regulation plays the dominate role for signaling.     

Amino-Acid-Induced Circular Polarized Luminescence in One-Dimensional Manganese(II) Halide Hybrid

Circular polarized luminescence (CPL)-active materials attract great attentions owing to their widely applications in 3D optical displays and encrypted transmission. Inspired by the strategies adopted in perovskite based CPL materials, herein, CPL-active hybrids (D)- and (L)-(tert-butyl prolinate)MnCl₃ were successfully prepared by assembling chiral D/L tert-butyl prolinate with manganese (II) chloride. Single crystal structures show the as-formed hybrids possess one-dimensional (1D) structure containing linear chains of face-sharing MnCl₆ octahedral surrounded by prolinate cations. The 1D Mn(II) hybrids display strong red emission peaked at 646 nm with PLQY of 67.1 % and 57.2 % for d -type and l -type, respectively, representing the highest PLQY for 1D Mn^II hybrids. Interestingly, the 1D Mn(II) hybrids exhibit prominent circular dichroism (CD) signals and remarkable CPL activity with the dissymmetry factor g of 6.1*10⁻³ and −6.3*10⁻³ from 550 to 800 nm for (D)- and (L)-(tert-butyl prolinate)MnCl₃, respectively, owing to the existence of chiral cations. It is worthy noted the obtained g represents the highest value for non-lead organic–inorganic hybrids.     

Dynamical analysis of age-structured pertussis model with covert infection

An age-structured pertussis model with covert infection is proposed to understand the effect of covert infection on the recurrence of pertussis. It is found that vaccination only for young children does not have a decisive effect on whooping cough control. It is shown that although the vaccine coverage rate is relatively high, the model has a backward bifurcation for a larger covert infection rate. In addition, sufficient conditions for the disease-free steady state to be globally asymptotically stable are obtained.     

Enantioselective Total Synthesis of Pseudopteroxazole and Ileabethoxazole

Enantioselective total syntheses of pseudopteroxazole ( 1 ) and ileabethoxazole ( 2 ) are presented. The two original stereocenters were constructed in excellent enantioselectivity and good diastereoselectivity through Carreira's asymmetric dual catalytic allylation, which shows potential for accessing diastereoisomers at C2 and C3 of 1 and 2 . Cationic cyclizations of 13 and 24 demonstrated an effective pathway for the construction of the opposite configurations at C1 in 1 and 2 . Additionally, an approach for the introduction of methyl at C4 is a feasible solution for structural modifications at C4 in 1 and 2 .     

Two weight commutators in the Dirichlet and Neumann Laplacian settings

In this paper we establish the characterization of the weighted BMO via two weight commutators in the settings of the Neumann Laplacian ${\mathrm{\Delta }}_{N_{+}}$ on the upper half space ${\mathbb{R}}_{+}^n$ and the reflection Neumann Laplacian ${\mathrm{\Delta }}_N$ on ${\mathbb{R}}^n$ with respect to the weights associated to ${\mathrm{\Delta }}_{N_{+}}$ and ${\mathrm{\Delta }}_N$ respectively. This in turn yields a weak factorization for the corresponding weighted Hardy spaces, where in particular, the weighted class associated to ${\mathrm{\Delta }}_N$ is strictly larger than the Muckenhoupt weighted class and contains non-doubling weights. In our study, we also make contributions to the classical Muckenhoupt–Wheeden weighted Hardy space (BMO space respectively) by showing that it can be characterized via the area function (Carleson measure respectively) involving the semigroup generated by the Laplacian on ${\mathbb{R}}^n$ and that the duality of these weighted Hardy and BMO spaces holds for Muckenhoupt $A^p$ weights with $p\in (1,2]$ while the previously known related results cover only $p\in (1,\frac{n+1}{n}]$. We also point out that this two weight commutator theorem might not be true in the setting of general operators L, and in particular we show that it is not true when L is the Dirichlet Laplacian ${\mathrm{\Delta }}_{D_{+}}$ on ${\mathbb{R}}_{+}^n$.     

3D Organic–Inorganic Perovskite Ferroelastic Materials with Two Ferroelastic Phases: [Et3P(CH2)2F][Mn(dca)3] and [Et3P(CH2)2Cl][Mn(dca)3]

Organic–inorganic hybrid perovskite-type multiferroics have attracted considerable research interest owing to their fundamental scientific significance and promising technological applications in sensors and multiple-state memories. The recent achievements with divalent metal dicyanamide compounds revealed such malleable frameworks as a unique platform for developing novel functional materials. Herein, two 3D organic–inorganic hybrid perovskites [Et₃P(CH₂)₂F][Mn(dca)₃] ( 1 ) and [Et₃P(CH₂)₂Cl][Mn(dca)₃] ( 2 ) (dca=dicyanamide, N(CN)₂⁻) are presented. Accompanying the sequential phase transitions, they display a broad range of intriguing physical properties, including above room temperature ferroelastic behavior, switchable dielectricity, and low-temperature antiferromagnetic ordering (T_c=2.4 K for both 1 and 2 ). It is also worth noting that the spontaneous strain value of 1 is far beyond that of 2 in the first ferroelastic phase, as a result of the precise halogen substitution. From the point view of molecular design, this work should inspire further exploration of multifunctional molecular materials with desirable properties.