Dehalogenation of α -haloketones and vic-dibromides with nickel boride

α-Haloketones and $\text{vic}$-dibromides are converted to the corresponding ketones and alkenes respectively with nickel boride generated $\text{in situ}$ from sodium borohydride and nickel chloride.     

A reinvestigation of the structures of acomonine,iliensine, 14-dehydroiliensine,and 14-benzoyliliensine

The novel structures assigned by Yunusov et al to the C₁₉-diterpenoid alkaloids, acomonine ($\text{1}$), iliensine ($\text{2}$), 14-dehydroiliensine ($\text{3}$), and 14-bensoyliliensine ($\text{4}$) have been found to be in error. We have demonstrated that these alkaloids are identical with the well-known alkaloids, delsoline ($\text{5}$), delcosine ($\text{6}$), 14-dehydrodeloosine ($\text{7}$), and 14-benzoyldelcosine ($\text{8}$), respectively.     

Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids

[structure: see text]. Pure alpha-azido acids were prepared using an efficient diazo transfer method followed by buffered workup. These building blocks were used to prepare small peptides on Wang resin by two approaches. Peptides prone to diketopiperazine formation were prepared in good yields by coupling acids to resin bound iminophosphoranes during Fmoc-Wang synthesis. The iminophosphoranes can also be hydrolyzed under neutral conditions to provide unprotected amines ready for further coupling.     

Analyse des lanthanides,du hafnium,du scandium,du chrome,du manganese,du cobalt,du cuivre et du zinc dans les mineraux et les roches par activation neutronique

Résumé Pour utiliser au mieux les possibilités de l'analyse par activation et de la spectrométrie γ à l'aide des détecteurs à semi-conducteurs, nous proposons des schémas de séparations rapides qui permettent d'effectuer les analyses de routine des lanthanides, du scandium, du chrome, du manganèse, du cobalt, du cuivre et du zinc, dans la plupart des minéraux et des roches avec une précision comprise entre 3 et 10%. La méthode a été appliquée à une grande variété d'échantillons et testée sur des standards. Nous montrons par quelques exemples tout son intérêt dans les études géochimiques systématiques des éléments de transition.     

Copper triflate/t-BuOOAc-catalyzed amidation of allylic and benzylic acetates with sulfonamides

A copper triflate/t-BuOOAc-catalyzed amidation of allylic and benzylic acetates has been developed which is suitable for the coupling of a wide variety of functionalized sulfonamide nucleophiles with acetate electrophiles. The methodology allows for the amidation of benzylic substrates which are not further activated by an additional adjacent alkene or alkyne, enabling simple allylic acetates and primary benzylic acetates to be used as reaction partners.     

On the use of multi-state multi-census techniques for modelling the survival of elderly people in institutional long-term care

^** Corresponding author. Email: chausst{at}wmin.ac.uk A good estimate of the length of stay (LOS) of elderly peoplein institutional long-term care (ILTC) is essential to bothcare providers (care home owners) and purchasers (local authoritiesin the UK) in order to forecast their resource availabilityand future requirements. Existing methods usually rely on cohortdata, which needs to be collected on a continuous basis forseveral years and are often not available electronically. Inthis paper we develop an approach based on multi-census datato fit a Markov model in continuous-time for the LOS of elderlypeople in ILTC (residential and nursing care). We use 3 yearplacement data provided by London Borough of Merton Social Servicesto compare the estimates of the model parameters obtained usingmulti-census data with those derived from cohort data, henceto validate the multi-census approach in this context. The implicationsof the proposed multi-census approach and its advantages inthe context of long-term care planning are discussed.     

The structure of the π-molecular complex between 1,4-dihydro-9,10-anthrahydroquinone and 1,4-dihydro-9,10-anthraquinone

The structure of the π-molecular complex (10) was assigned on the basis of the solid state¹³C-nmr spectrum. The solid state¹³C-nmr spectrum of quinhydrone (12) has also been determined. Accurate¹H and¹³C chemical shift assignments have been made for the compounds3,5,6,7,8, and10 on the basis of HMQC and HMBC spectral data. The π-molecular complex10 crystallizes in the space groupP2₁ In with cell parameters:a=4.052 (1) Å,b=6.477 (1) Å,c=19.093 (2) Å, β=90.17 (1)^o,z=1,D _c =1.400 g mc^?32. Crystal and molecular structure of the title compound, C₂₈H₂₂O₄, has been determined by an X-ray analysis of10 by direct methods from diffractometer data and refined by full-matrix least-squares