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121.
Julia Ertl Dr. Maria Elena Ortiz-Soto Thien Anh Le Julian Bechold Junwen Shan Dr. Jörg Teßmar Prof. Bernd Engels Prof. Jürgen Seibel 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(26):6533-6541
Selective chemical modification of proteins plays a pivotal role for the rational design of enzymes with novel and specific functionalities. In this study, a strategic combination of genetic and chemical engineering paves the way for systematic construction of biocatalysts by tuning the product spectrum of a levansucrase from Bacillus megaterium (Bm-LS), which typically produces small levan-like oligosaccharides. The implementation of site-directed mutagenesis followed by a tyrosine-specific modification enabled control of the product synthesis: depending on the position, the modification provoked either enrichment of short oligosaccharides (up to 800 % in some cases) or triggered the formation of high molecular weight polymer. The chemical modification can recover polymerization ability in variants with defective oligosaccharide binding motifs. Molecular dynamic (MD) simulations provided insights into the effect of modifying non-native tyrosine residues on product specificity. 相似文献
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We study “large” nonnegative solutions for a class of quasilinear equations model of which is We give a sufficient condition on the exponents and for the removability of isolated singularities. 相似文献
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Acta Mathematicae Applicatae Sinica, English Series - For a graph G = (V, E) without isolated vertex, a function f: E(G) → {−1, 1} is said to be a signed star dominating function of G... 相似文献
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Dr. Wenyan Hao Yuchen Sha Dr. Yi Deng Yi Luo Li Zeng Shan Tang Dr. Yue Weng Prof. Dr. Chien-Wei Chiang Prof. Dr. Aiwen Lei 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(19):4931-4934
An in situ generated oxidation species of nickel quinolinylpropioamide intermediate was produced. Characterization by X-ray absorption near edge structure (XANES) and EPR provides complementary insights into this oxidized nickel species. With aliphatic amides and isocyanides as substrates, a nickel-catalyzed facile synthesis of structurally diverse five-membered lactams could be achieved. 相似文献
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Six mono/double‐layered 2D and three 3D coordination polymers were synthesized by a self‐assembly reaction of Zn (II) salts, organic dicarboxylic acids and L1/L2 ligands. These polymeric formulas are named as [Zn(L1)(C4H2O4)0.5 (H2O)]n·0.5n(C4H2O4)·2nH2O ( 1 ), [Zn2(L2)(C4H2O4)2]n·2nH2O ( 2 ), [Zn(L1)(m‐BDC)]n ( 3 ), [Zn2(L2)(m‐BDC)2]n·2nH2O ( 4 ), [Zn3(L1)2(p‐BDC)3(H2O)4]n·2nH2O ( 5 ), [Zn2(OH)(L2) (p‐BDC)1.5]n ( 6 ), [Zn2(L1)(p‐BDC)2]n·5nH2O ( 7 ), [Zn2(L2)(p‐BDC)2]n·3nH2O ( 8 ) and [Zn2(L1)(C4H4O4)1.5(H2O)]n·n(ClO4)·nH2O ( 9 ) [L1 = N,N′‐bis (pyridin‐4‐ylmethyl)propane‐1,2‐diamine, L2 = N,N′‐bis (pyridin‐3‐ylmethyl)propane‐1,2‐ diamine, m‐BDC2? = m‐benzene dicarboxylate, p‐BDC2? = p‐benzene dicarboxylate]. Meanwhile, these polymers have been characterized by elemental analysis, infrared, thermogravimetry (TG), photoluminescence, powder and single‐crystal X‐ray diffraction. Polymers 1–6 present mono‐ and double (4,4)‐layer motifs accomplished by L1/L2 ligands with diverse conformations and organic dicarboxylates, and the layer thickness locates in the range of 5.8–15.0 Å. In three 3D polymers, the L1 and L2 molecules adopt the same cis‐conformations and join adjacent Zn (II) cations together with p‐BDC2? or succinate, giving rise to different binodal (4,4)‐c nets with (4.52.83)(4.53.72) ( 7 ), pts ( 8 ) topology and twofold interpenetrated binodal (5,5)‐c nets with (32.44.52.62)(3.43.52.64) ( 9 ). Therefore, the diverse conformations of the two bis (pyridyl)‐propane‐1,2‐diamines and the feature of different organic dicarboxylate can effectively influence the architectures of these polymers. Powder X‐ray diffraction patterns demonstrate that these bulk solid polymers are pure phase. TG analyses indicate that these polymers have certain thermal stability. Luminescent investigation reveals that the emission maximum of these polymers varies from 402 to 449 nm in the solid state at room temperature. Moreover, 1 , 3 and 5–8 show average luminescence lifetimes from 8.81 to 16.30 ns. 相似文献
129.
Fanfan Du Ying Zheng Wenhua Yuan Guorong Shan Yongzhong Bao Suyun Jie Pengju Pan 《Journal of polymer science. Part A, Polymer chemistry》2019,57(2):90-100
Development of effective organocatalysts for the living ring‐opening polymerization (ROP) of lactones is highly desired for the preparation of biocompatible and biodegradable polyesters with controlled microstructures and physical properties. Herein, a new class of hydrogen‐bond donating bisurea catalysts is reported for the ROP of lactones under solvent‐free conditions. ROP of lactones mediated by the bisurea/7‐methyl‐1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene (MTBD) catalyst exhibits a living/controlled manner, affording the polymers and copolymers with the well‐defined structure, predictable molecular weight, narrow molecular weight distribution, and high selectivity for monomer at low catalyst loadings at ambient temperature. The possible mechanism of bisurea/MTBD‐catalyzed ROP of lactones is proposed, in which the bisurea activates the carbonyl group of lactones while MTBD facilitates the nucleophilic attack of the initiating/propagating alcohol by hydrogen bonding. Moreover, the poly(ε‐caprolactone‐co‐δ‐valerolactone) [P(CL‐co‐VL)] random copolymers with various compositions were synthesized using the bisurea/MTBD catalyst. The measurements of thermal properties and crystalline structure demonstrate that the CL and VL units are cocrystallized in the crystalline phase of P(CL‐co‐VL) copolymers. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 90–100 相似文献
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