Effects of background noise level on behavioral estimates of basilar-membrane compression

Hearing-impaired (HI) listeners often show poorer performance on psychoacoustic tasks than do normal-hearing (NH) listeners. Although some such deficits may reflect changes in suprathreshold sound processing, others may be due to stimulus audibility and the elevated absolute thresholds associated with hearing loss. Masking noise can be used to raise the thresholds of NH to equal the thresholds in quiet of HI listeners. However, such noise may have other effects, including changing peripheral response characteristics, such as the compressive input-output function of the basilar membrane in the normal cochlea. This study estimated compression behaviorally across a range of background noise levels in NH listeners at a 4 kHz signal frequency, using a growth of forward masking paradigm. For signals 5 dB or more above threshold in noise, no significant effect of broadband noise level was found on estimates of compression. This finding suggests that broadband noise does not significantly alter the compressive response of the basilar membrane to sounds that are presented well above their threshold in the noise. Similarities between the performance of HI listeners and NH listeners in threshold-equalizing noise are therefore unlikely to be due to a linearization of basilar-membrane responses to suprathreshold stimuli in the NH listeners.     

Molecular relaxation of isotactic polystyrene: Real‐time dielectric spectroscopy and X‐ray scattering studies*

The molecular relaxation processes and structure of isotactic polystyrene (iPS) films were investigated with real‐time dielectric spectroscopy and simultaneous wide‐ and small‐angle X‐ray scattering. The purpose of this work was to explore the restrictions imposed on molecular mobility in the vicinity of the α relaxation (glass transition) for crystallized iPS. Isothermal cold crystallization at temperatures of T_c = 140 or 170 °C resulted in a sigmoidal increase of crystallinity with crystallization time. The glass‐transition temperature (T_g), determined calorimetrically, exhibited almost no increase during the first stage of crystal growth before impingement of spherulites. After impingement, the calorimetric T_g increased, suggesting that confinement effects occur in the latter stages of crystallization. For well‐crystallized samples, the radius of the cooperativity region decreased substantially as compared with the purely amorphous sample but was always smaller than the layer thickness of the mobile amorphous fraction. Dielectric experiments directly probed changes in the amorphous dipole mobility. The real‐time dielectric data were fitted to a Havriliak–Negami model, and the time dependence of the parameters describing the distribution of relaxation times and dielectric strength was obtained. The central dipolar relaxation time showed little variation before spherulite impingement but increased sharply during the second stage of crystal growth as confinement occurred. Vogel–Fulcher–Tammann analysis demonstrated that the dielectric reference temperature, corresponding to the onset of calorimetric T_g, did not vary for well‐crystallized samples. This observation agreed with a model in which constraints affect primarily the modes having longer relaxation times and thus broaden the glass‐transition relaxation process on the higher temperature side. © 2004 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 42: 777–789, 2004     

Impact of Nanosilicates on Poly(vinylidene fluoride) Crystal Polymorphism: Part 2. Melt-crystallization at Low Supercooling

Nanocomposites of poly(vinylidene fluoride) (PVDF) filled with Lucentite STN^TM organically modified silicate (OMS) were investigated upon melt-crystallization at temperatures near its melting point (i.e., at low supercooling temperatures). Previously, we showed that the addition of extremely small amounts of OMS into PVDF causes the polar beta phase formation in cold-crystallized samples, and causes polar gamma phase formation in melt-crystallized samples under high supercooling. The current study focused on the impact of OMS on polymorphic behavior of PVDF crystallized from the molten state, or annealed, at low supercooling temperatures. Nanocomposites with 0–4.0 wt% concentration were prepared from solutions. The existence of α or γ phase was verified by using Fourier transform infrared spectroscopy, wide-angle X-Ray scattering or Differential Scanning Calorimetry (DSC). Morphology of α- and γ-spherulites was observed by polarizing optical microscopy (POM). In annealed PVDF/OMS nanocomposites, gamma crystals were observed to dominate at all clay compositions except 0.01 wt%. DSC and POM data show that two types of gamma crystals, γ and γ’, exist when PVDF/OMS nanocomposites were annealed.     

Condensation of Cp2TiCI2 with Tetraamines

The synthesis of titanium polyamines from tetraamines is general and rapid. Systems utilizing equimolar quantities of reactants produce linear products, whereas tri- and tetra-substitution occurs when excess Cp₂TiCl₂ is used. The products exhibit moderate high-temperature stability but poor low-temperature stability, with degradation occurring via nonoxidative routes to ca. 200°C, and by oxidative routes in air at higher temperatures.     

Promoting Equity in Secondary Science and Mathematics Classrooms With Biography Projects

Teachers have been called upon to give their students the opportunity to consider the perspectives of diverse individuals across the science and mathematics curriculum. This is because inclusion enhances motivation and achievement. Biographies provide context for construction of knowledge, vicarious experiences, positive attitudes toward instruction, and literacy enhancement. The purpose of this paper is to provide a rationale for including biography projects representing diverse contributors to science and mathematics, describe a biography project assignment used in a methods course for secondary teacher preparation, provide preservice teachers' comments about the assignment, and make connections to current research about equitable instruction.     

Thin film assembly of spider silk-like block copolymers

We report the self-assembly of monolayers of spider silk-like block copolymers. Langmuir isotherms were obtained for a series of bioengineered variants of the spider silks, and stable monolayers were generated. Langmuir-Blodgett films were prepared by transferring the monolayers onto silica substrates and were subsequently analyzed by atomic force microscopy (AFM). Static contact angle measurements were performed to characterize interactions across the interface (thin film, water, air), and molecular modeling was used to predict 3D conformation of spider silk-like block copolymers. The influence of molecular architecture and volume fraction of the proteins on the self-assembly process was assessed. At high surface pressure, spider silk-like block copolymers with minimal hydrophobic block (f(A) = 12%) formed oblate structures, whereas block copolymer with a 6-fold larger hydrophobic domain (f(A) = 46%) formed prolate structures. The varied morphologies obtained with increased hydrophobicity offer new options for biomaterials for coatings and related options. The design and use of bioengineered protein block copolymers assembled at air-water interfaces provides a promising approach to compare 2D microstructures and molecular architectures of these amphiphiles, leading to more rationale designs for a range of nanoengineered biomaterial needs as well as providing a basis of comparison to more traditional synthetic block copolymer systems.     

Persistent Random Walks. I. Recurrence Versus Transience

We consider a walker on the line that at each step keeps the same direction with a probability which depends on the time already spent in the direction the walker is currently moving. These walks with memories of variable length can be seen as generalizations of directionally reinforced random walks introduced in Mauldin et al. (Adv Math 117(2):239–252, 1996). We give a complete and usable characterization of the recurrence or transience in terms of the probabilities to switch the direction and we formulate some laws of large numbers. The most fruitful situation emerges when the running times both have an infinite mean. In that case, these properties are related to the behaviour of some embedded random walk with an undefined drift so that these features depend on the asymptotics of the distribution tails related to the persistence times. In the other case, the criterion reduces to a null-drift condition. Finally, we deduce some criteria for a wider class of persistent random walks whose increments are encoded by a variable length Markov chain having—in full generality—no renewal pattern in such a way that their study does not reduce to a skeleton RW as for the original model.     

The Value of Trade Books in Secondary Science and Mathematics Instruction: A Rationale

A rationale for the inclusion of trade books (i.e., fiction, nonfiction, biographies, autobiographies, reports of discoveries, poetry, science fiction) is offered to secondary science and mathematics instructors. The benefits of trade books include context for problem posing and solving while promoting constructivist-based instruction. Trade books provide students with vicarious experiences of the science and mathematics process, as they afford young people introductions to people and ideas which they may not know otherwise. Trade books promote positive attitudes toward science and mathematics instruction because they present a distinctive point of view and celebrate diversity of achievement. Trade books contain the ingredients necessary for emotional growth: romance, wonder and awe. In addition, trade books foster students' literacy development, since students are likely to conduct personalized inquiry, monitor their thinking and spend more time actively engaged in reading due to the variety and appeal of trade books. Importantly, teacher and student responses show reflection and ownership when trade books are used during instruction. Examples of books and quotes are included.     

Understanding speech in modulated interference: cochlear implant users and normal-hearing listeners

Many competing noises in real environments are modulated or fluctuating in level. Listeners with normal hearing are able to take advantage of temporal gaps in fluctuating maskers. Listeners with sensorineural hearing loss show less benefit from modulated maskers. Cochlear implant users may be more adversely affected by modulated maskers because of their limited spectral resolution and by their reliance on envelope-based signal-processing strategies of implant processors. The current study evaluated cochlear implant users' ability to understand sentences in the presence of modulated speech-shaped noise. Normal-hearing listeners served as a comparison group. Listeners repeated IEEE sentences in quiet, steady noise, and modulated noise maskers. Maskers were presented at varying signal-to-noise ratios (SNRs) at six modulation rates varying from 1 to 32 Hz. Results suggested that normal-hearing listeners obtain significant release from masking from modulated maskers, especially at 8-Hz masker modulation frequency. In contrast, cochlear implant users experience very little release from masking from modulated maskers. The data suggest, in fact, that they may show negative effects of modulated maskers at syllabic modulation rates (2-4 Hz). Similar patterns of results were obtained from implant listeners using three different devices with different speech-processor strategies. The lack of release from masking occurs in implant listeners independent of their device characteristics, and may be attributable to the nature of implant processing strategies and/or the lack of spectral detail in processed stimuli.     

New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity

Polyamine toxins (PATs) are conjugates of polyamines (PAs) with lipophilic carboxylic acids, which have been recently shown to present antiproliferative activity. Ten analogs of the spider PATs Agel 416, HO-416b, and JSTX-3 and the wasp PAT PhTX-433 were synthesized with changes in the lipophilic head group and/or the PA chain, and their antiproliferative activity was evaluated on MCF-7 and MDA-MB-231 breast cancer cells, using Agel 416 and HO-416b as reference compounds. All five analogs of PhTX-433 were of very low activity on both cell lines, whereas the two analogs of JSTX-3 were highly active only on the MCF-7 cell line with IC₅₀ values of 2.63–2.81 μΜ. Of the remaining three Agel 416 or HO-416b analogs, only the one with the spermidine chain was highly active on both cells with IC₅₀ values of 3.15–12.6 μM. The two most potent compounds in this series, Agel 416 and HO-416b, with IC₅₀ values of 0.09–3.98 μΜ for both cell lines, were found to have a very weak cytotoxic effect on the MCF-12A normal breast cells. The present study points out that the structure of both the head group and the PA chain determine the strength of the antiproliferative activity of PATs and their selectivity towards different cells.