Enantiomeric separation of acidic compounds using single-isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis

The enantiomeric separation of a series of acidic pharmaceuticals (mostly nonsteroidal anti-inflammatory drugs) has been investigated in NACE systems using single-isomer amino beta-CD derivatives. The first part of this study consisted of the selection of the basic experimental conditions to separate efficiently the enantiomers of acidic drugs. Several parameters, such as the nature of the ionic BGE components, were studied and a methanolic solution of ammonium acetate containing the cationic CD was selected as BGE. A D-optimal design with 20 experimental points was then applied and the nature and concentration of the CD were found to have a significant effect on the enantiomeric resolution for all studied compounds. Resolution (R(s)) values were always higher with 6-monodeoxy-6-mono(3-hydroxy)propylamino-beta-CD (PA-beta-CD) compared to those obtained with 6-monodeoxy-6-mono(2-hydroxy)propylamino-beta-CD (IPA-beta-CD). However, the latter led to shorter migration times. Generic NACE conditions were then selected by means of the multivariate approach in order to obtain the highest R(s) values in a minimum amount of time. Finally, dependence of separation selectivity, resolution, as well as mobility difference on chiral selector concentration was discussed and binding constants with PA-beta-CD were estimated for the two enantiomers of one of the model compounds, suprofen in these NACE systems.     

Bridgman growth and site occupation in LuAG:Ce scintillator crystals

LuAG:Ce single crystals with various activator concentrations were grown by the vertical Bridgman technique. Characterization of crystals was done in terms of actual doping level, macroscopic defects and degree of non-equivalent substitutions by Lu for Al in octahedral lattice sites. Scintillation measurements were performed using 2×2×8 mm³ shaped samples with Ce concentration in the range 0.05–0.55 at%. Essential improvement of performance was demonstrated in samples containing ≥0.2 at% of Ce; the light yield measured in LuAG:Ce (0.55 at%) was about 26000 ph/MeV, or close to that of LSO.     

Aperture synthesis in phase retrieval using a volume-speckle field

The resolution of the reconstructed wave by a phase-retrieval method using a volume-speckle field depends on the aperture defined by the size of the CCD array. The use of a larger aperture is introduced by measuring the speckle field at two different positions in the transverse plane and stitching the measurements together. Improvements in the quality of reconstructions are demonstrated experimentally and by computer simulations. Undesirable effects of camera tilt on the quality of reconstructions from synthetic aperture intensity measurements are experimentally observed and corrected.     

Contributions from higher twist effects to the quark fragmentation functions in neutrino data

Quark fragmentation functions are studied with ≈3500 charged current events induced in the bubble chamber Gargamelle by neutrinos of the SPS wide band beam, with 〈E_ν〉 ≈ 25 GeV. The Q² and W² regions covered by this experiment are Q² ≈ 0–40 GeV² and W² ≈ 1–100 GeV², the mean values being 〈Q²〉 = 6.5 GeV², 〈W²〉 = 22GeV². A correlation between the variables $\text{z =}\text{E}{}_{\mathrm{\pi }}\text{E}{}_{\mathrm{<mtext>H</mtext>}}$ and $\text{y =}\text{E}{}_{\mathrm{<mtext>H</mtext>}}\text{E}{}_{\mathrm{v}}$ is found in the data in the region Q² = 1–10 GeV², which can be explained in terms of higher twist effects. These effects reproduce the Q² evolution of the non-singlet moments of the fragmentation function without any need for logarithmic terms.     

Interest for thin scintillating films

This paper reports on the interest for developing thin scintillating films deposited on various substrates for scintillation purposes. The first part will present some advantages of films for fundamental studies. Mainly they are helpful (when deposited on CaF 2 ) for spectroscopic measurements when absorption coefficient is very high (as for CeF 3 ) or when excitation energies are near the fundamental absorption edge. When deposited on silicon substrate, photoelectron spectroscopy may be performed without any charging effects. The second part describes applications using film shaped scintillators, like high resolution X-ray imaging.     

Phase retrieval using multiple illumination wavelengths

An iterative phase retrieval method is proposed, which uses a sequence of diffraction intensity patterns recorded at different wavelengths. This method has a rapid convergence, and a high immunity to noise and environmental disturbance. The wrap-free phase measurement range is also extended based on the principle of two-wavelength interferometry. Simulation and experimental results are presented to demonstrate the approach.     

Bridgman Growth and Characterization of LuAlO3—Ce3+ Scintillator Crystals

Chemical and structural effects in LuAlO₃-Ce³⁺ single crystals grown by the Bridgman method were studied using spectral emission, x-ray, etching and optical techniques. The Ce concentration distribution was found to exhibit the normal freeze behavior with partition coefficient of 0,17. The expansion of the unit cell volume due to incorporation of Ce was measured. Dislocation etch pits were revealed on (010), (100) and (001) crystal faces. Thermal expansion behavior of LuAlO₃ was studied along the major crystallographic axes in between the room temperature and 1000 °C. The scintillation performance of 5 × 5 × 10 mm³ samples was measured using a 662 keV gamma source with a shaping time of 1.2 μs. The light yield was increasing from 40% BGO to 70% BGO with increasing of the Ce³⁺ content from 0.13 at.% to 0.9 at.%.     

Fermentation Monitoring Based on HPTLC-OPLC. The Effect of a Complex Biological Matrix on Quantitative Performance

JPC – Journal of Planar Chromatography – Modern TLC - An OPLC method has been established for separation and quantification of eight carbohydrates (glucose, fructose, galactose,...     

On the finite dimensionality of a K3 surface

For a smooth projective surface X the finite dimensionality of the Chow motive h(X), as conjectured by Kimura, has several geometric consequences. For a complex surface of general type with p _g = 0 it is equivalent to Bloch’s conjecture. The conjecture is still open for a K3 surface X which is not a Kummer surface. In this paper we prove some results on Kimura’s conjecture for complex K3 surfaces. If X has a large Picard number ρ = ρ(X), i.e. ρ = 19,20, then the motive of X is finite dimensional. If X has a non-symplectic group acting trivially on algebraic cycles then the motive of X is finite dimensional. If X has a symplectic involution i, i.e. a Nikulin involution, then the finite dimensionality of h(X) implies ${h(X) \simeq h(Y)}$ , where Y is a desingularization of the quotient surface ${X/\langle i \rangle }$ . We give several examples of K3 surfaces with a Nikulin involution such that the isomorphism ${h(X) \simeq h(Y)}$ holds, so giving some evidence to Kimura’s conjecture in this case.     

Fluorescence properties of Bi4Ge3O12(BGO) single crystals under laser excitation: Excited state dynamics and saturation effects

Laser-excited techniques were used to investigate the optical properties of bismuth germanate crystals. Absorption, reflectivity, excitation, emission, lifetime, time-resolved fluorescence, photoconductivity, thermally stimulated conductivity measurements were performed at various temperatures on single crystals of different origins.The absorption is shown to occur in bismuth and germanate centers while both intrinsic and perturbed Bi³⁺ ions together with impurities contribute to the total fluorescence.The emission mechanism at room temperature involves a thermally activated energy migration, and at low temperature localized emitting centers. Formation of deep holes in the wide emission band at room temperature reveals saturation effects on various luminescent centers, promoted by energy migration. Trapped exciton models are proposed to explain the excited state dynamics occurring at low and room temperature.