Optical and transport properties of chemical bath deposited CdS: Al films

Aluminium doped and undoped CdS films are deposited on the glass substrates by chemical bath deposition technique. Their optical and transport properties are studied and the effect of dopant concentration on these properties is discussed at length.     

Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists

A novel class of (5-(pent-1-enyl)thiophen-2-yl)pyrazole antagonists was discovered, many of which exhibited potent CB1 activity and good CB1/2 selectivity, suggesting that along with a 1,3-transposition of the carbonyl of the pyrazole 3-carboxamide, bioisosteric replacement of the conventional pyrazole 5-aryl group with a thienyl ring substituted with an appropriate alkenyl moiety is viable.     

Synthesis of highly functionalized 2(1H)-pyrazinone 3-carboxamide scaffolds

Synthesis of highly functionalized 2(1H)-pyrazinone 3-carboxamide derivatives is reported. A one-pot, two-step process including the base-mediated reaction of N,N-disubstituted aminoacetonitrile derivatives 18 with 3,5-dihalo-2(1H)-pyrazinones 1 afforded substituted aminoacetonitrile pyrazinone derivative 19, which on subsequent oxidation followed by transamidation of the resulting intermediate with primary or secondary amines gave the corresponding highly functionalized 2(1H)-pyrazinone 3-carboxamide derivatives 21.     

Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1<Emphasis Type="Italic">H</Emphasis>-pyrazol-5-ol)s

An ethylene glycol promoted catalyst-free practically efficient and sustainable approach has been developed for the synthesis of several benzylidene-bis-(4-hydroxycoumarin)s and 4,\(4^{\prime }\)-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s by the pseudo three-component reaction of an aldehyde with 4-hydroxycoumarin and 3-methyl-1-phenylpyrazol-5-one, respectively. Inexpensive, non-toxic, and easily available ethylene glycol used as the reaction solvent and promoter renders an efficient protocol in terms of catalyst-free reaction conditions, short reaction time, high yield, practical utility, and green approach.     

Chemical fingerprinting of Hoodia species and related genera: chemical analysis of oxypregnane glycosides using high-performance liquid chromatography with UV detection in Hoodia gordonii

Hoodia gordonii, family Asclepiadaceae, is a succulent plant and is traditionally used in southern Africa for its appetite-suppressant properties. A high-performance liquid chromatographic (HPLC) method with UV detection for analysis of 11 oxypregnane glycosides from H. gordonii has been developed. The simultaneous analysis of 11 oxypregnane glycosides was achieved with a Phenomenex (Torrance, CA) reversed-phase C18 column using gradient mobile phase of water and acetonitrile, both containing 0.025% trifluoroacetic acid. The developed method was applied to the identification of oxypregnane glycosides in 3 different species of Hoodia and 23 related genera. The HPLC profiles of various plant samples were compared for the presence of oxypregnane glycosides.     

Liquid–liquid extraction of thorium(IV) with N-n-heptylaniline from acid media

The extraction behavior of thorium(IV) from sulphuric acid medium with N-n-heptylaniline in xylene. Various parameters like reagent concentration, acid concentration, equilibration time, diverse ions and effect of diluents were studied. Thorium(IV) was selectively extracted and separated from many metal ions. The nature of the extracted species was determined. Thorium(IV) was analyzed from monazite ore and gas mantle.

     

Diversity in Gold‐Catalyzed Formal Cycloadditions of Ynamides with Azidoalkenes or 2H‐Azirines: [3+2] versus [4+3] Cycloadditions

Gold‐catalyzed cycloadditions of ynamides with azidoalkenes or 2H‐azirines give [3+2] or [4+3] formal cycloadducts of three classes. Cycloadditions of ynamides with 2H‐azirine species afford pyrrole products with two regioselectivities when the C_β‐substituted 2H‐azirine is replaced from an alkyl (or hydrogen) with an ester group. For ynamides substituted with an electron‐rich phenyl group, their reactions with azidoalkenes proceed through novel [4+3] cycloadditions to deliver 1H‐benzo[d]azepine products instead.     

Heat transfer and fluid flow analysis of artificially roughened ducts having rib and groove roughness

Artificially roughness is one of the well known methods of enhancing heat transfer from the heat transfer surface in the form of repeated ribs, grooves or combination of ribs and groove (compound turbulators). The artificial roughness produced on the heat transferring surface is used in cooling of gas turbine blades, nuclear reactor, solar air heating systems etc. Solar air heaters have wide applications in low to moderate temperature range, namely, drying of foods, agricultural crops, seasoning of wood and space heating etc. Solar air heaters have low value of convective heat transfer coefficient between the working fluid (air) and the heat transferring surface, due to the formation of thin laminar viscous sub-layer on its surface. The heat transfer from the surface can be increased by breaking this laminar viscous sub layer. Hence, in the present work compound turbulators in the form of integral wedge shaped ribs with grooves are used on the heat transfer surface, to study its effect on the heat transfer coefficient (Nusselt number) and friction factor in the range of Reynolds number 3,000–18,000. The roughness produced on the absorber plate forms the wetted side of upper broad wall of the rectangular duct of solar air heater. The relative groove position (g/p) was varied from 0.4 to 0.8 and the wedge angle (Φ) was varied from 10° to 25°, relative roughness pitch (p/e) and relative roughness height (e/D) was maintained as 8.0 and 0.033 respectively. The aspect ratio of the rectangular duct was maintained as 8. The Nusselt number and friction factor of the artificially roughened ducts were determined experimentally and the corresponding values were compared with that of smooth surface duct. It is observed that wedge-groove roughened surface shows more enhancement in heat transfer compared to only rib roughened surface arrangement. The investigation revealed that Nusselt number increases 1.5–3 times, while the friction factor increases two to three folds that of the smooth surface duct in the range of operating parameters. It is also observed that in rib–groove roughness arrangement with relative groove position of 0.65 shows the maximum enhancement in the heat transfer compared to the other rib-groove roughness arrangements. Statistical correlations for the Nusselt number and friction factor have been developed by the regression method in terms of the operating and roughness parameters. A program was also developed in MATLAB for the calculation of thermal efficiency and thermal effectiveness. It was observed that the thermal efficiency is more for wedge angle of 15° and relative groove position of 0.65 and its value ranges from 42 to 73 %. The uncertainties in the measurements due to various instruments for the Reynolds number, Nusselt number, and friction factor have been estimated as ±3.8, ±4.54 and ±7.6 % respectively in the range of investigation made.     

Enantioselective formal synthesis of palmerolide A

Enantioselective formal synthesis of macrolactone palmerolide A, a polyketide marine natural product, is described. Key strategies in the synthesis include the oxidative furan ring-opening of a chiral furyl carbinol for the installation of the 1,4-dienol core and a Jung nonaldol-aldol reaction for the dienamide core.     

A theoretical charge density study on nitrogen-rich 4,4′,5,5′-tetranitro-2,2′-bi-1H-imidazole (TNBI) energetic molecule

The bond topological and electrostatic properties of nitrogen-rich 4,4′,5,5′-tetranitro-2,2′-bi-1H-imidazole (TNBI) energetic molecule have been calculated from the DFT method with the basis set 6-311G** and the AIM theory. The optimized geometry of this molecule is almost matched with the experimental geometric parameters. The electron density at the bond critical point and the Laplacian of electron density of C–NO₂ bonds are not equal, one of them is much weaker than the other. Similar trend exists in the C–N bonds of the imidazole ring of the molecule. The ratio of the bond dissociation energy (BDE) of the weakest bond to the molecular total energy exhibits nearly a linear correlation with the impact sensitivity; its h ₅₀% value is ~32.01 cm. The electrostatic potential around both the nitro groups are found unequal; the NO₂ group of weakest C–NO₂ bond exhibits an extended electronegative region.