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71.
meso Oxabicyclo[3.2.1]diazoketones underwent intramolecular C-H bond insertion to generate oxatricyclic compounds bearing fused cyclopentanones upon reaction with rhodium catalysts. Using the chiral catalyst Rh2(S-BPTTL)4, 44% ee was achieved in this desymmetrization reaction. 相似文献
72.
Many analytical approaches are available to evaluate (bio)molecular interactions, all of which have their particular advantages and disadvantages. In recent years, two relatively new techniques have emerged that may be used by the bioanalytical community to evaluate such interactions, namely affinity capillary electrophoresis (ACE) and bioaffinity electrospray ionization-mass spectrometry (ESI-MS). In this paper, we describe and evaluate the use of both these techniques for the investigation of the interactions of glycopeptide antibiotics with peptides that mimic the bacterial cell wall binding site. We focus particularly on the effect of the sugar moieties attached to the antibiotic peptide backbone and on the noncovalent dimerization of these glycopeptide antibiotics. 相似文献
73.
Parnia?Navabpour Carlos?RegaEmail author Christopher?J.?Lloyd David?Attwood Peter?A.?Lovell Pauline?Geraghty David?Clarke 《Colloid and polymer science》2005,283(9):1025-1032
The use of a diffusing-wave spectroscopy (DWS) technique for the particle size analysis of a series of suspensions of polymer latexes with diameters ranging between 90 nm and 1300 nm and volume fractions from 0.02 to 0.18 has been investigated. Particle sizes from DWS were in reasonable agreement with those from transmission electron microscopy and disc centrifuge photosedimentometry. Photon correlation spectroscopy was applicable only to the latexes with particle sizes less than 500 nm. For polymer latexes with volume fractions (Vf) up to 0.09, the decay rate of the autocorrelation function from DWS was related to the particle size over the range of particle sizes examined. At the highest volume fraction (Vf = 0.18), it was possible to distinguish between particles with diameters of 740 and 1,300 nm from their autocorrelation functions, but not between particles with diameters of 90 and 430 nm. 相似文献
74.
Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): a new, highly efficient difluorocarbene reagent
William R Dolbier Jr. Feng Tian An-Rong Li Olivia Bautista J Marshall Baker Pauline Anselme Aneta Modzelewska Merle A Battiste 《Journal of fluorine chemistry》2004,125(3):459-469
TFDA is readily prepared from the reaction of fluorosulfonyldifluoroacetic acid with trimethylsilyl chloride, and it is a very effective and efficient source of difluorocarbene for use in addition reactions to alkenes of a broad scope of reactivities. Acid-sensitive substrates may require an additional purification step involving treatment of the distilled TFDA with sufficient Et3N to remove the acid impurity. Other trialkylsilyl fluorosulfonyldifluoroacetates can also be prepared, and they have been found to have reactivities similar to TFDA. The triethyl derivative, TEFDA is more convenient to prepare in a pure state and has similar reactivity to TFDA. Thus, it may prove to be a superior reagent. 相似文献
75.
James N. Hay Pauline A. Fitzgerald 《Journal of polymer science. Part A, Polymer chemistry》1980,18(3):1079-1087
The molecular weight distribution of fractionated and unfractionated polystyrene samples has been determined by temperature drop turbidimetry, in which polymer is precipitated from dilute solutions in cyclohexanol by progressively cooling from 388 to 310 K. Estimates of the molecular weight averages and the polydispersities, obtained by calibration of the temperature of initial onset of precipitation, Ti, and the weight-average molecular weight were low, but could be substantially improved by correcting for concentration changes during precipitation. An empirical procedure correlating the breadth of turbidity-temperature curves to the logarithm of the polydispersity, as measured by gel permeation chromatography, appeared to be a simpler method of characterizing the polymer samples and as accurate as the computational methods above. 相似文献
76.
The algorithm for the research and design of optimized processes for synthesis of semisynthetic betalactam antibiotics with
the use of peptidases with mechanism of action based on the acylenzyme interm ediate formation as a catalyst was formulated.
The applicability of the proposed approach to the development of the processes for enzymatic synthesis of cefoxitin and cefazolin,
semisynthetic cephalosporins, as an example, was demonstrated. 相似文献
77.
Dr. Thibault Pariat Dr. Maxime Munch Martyna Durko-Maciag Prof. Dr. Jaroslaw Mysliwiec Dr. Pascal Retailleau Dr. Pauline M. Vérité Prof. Dr. Denis Jacquemin Dr. Julien Massue Dr. Gilles Ulrich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(10):3483-3495
2-(2’-Hydroxyphenyl)benzazole (HBX) fluorophores are well-known excited-state intramolecular proton transfer (ESIPT) emitters largely studied for their synthetic versatility, photostability, strong solid-state fluorescence and ability to engineer dual emission, thus paving the way to applications as white emitters, ratiometric sensors, and cryptographic dyes. However, they are heavily quenched in solution, due to efficient non-radiative pathways taking place as a consequence of the proton transfer in the excited-state. In this contribution, the nature of the heteroring constitutive of these rigidified HBX dyes was modified and we demonstrate that this simple structural modification triggers major optical changes in terms of emission color, dual emission engineering, and importantly, fluorescent quantum yield. Investigation of the photophysical properties in solution and in the solid state of a series of ethynyl-TIPS extended HBX fluorophores, along with ab initio calculations demonstrate the very promising abilities of these dyes to act as bright dual-state emitters, in both solution (even in protic environments) and solid state. 相似文献
78.
79.
A one pot, multi-component CuAAC reaction has been developed for the generation of alkyl, benzyl or aryl substituted bi and tridentate pyridyl-1,2,3-triazole ligands from their corresponding halides, sodium azide and alkynes in excellent yields. The ligands have been fully characterized by elemental analysis, HR-ESMS, IR, 1H and 13C NMR and in the ferrocenyl substituted cases the structures were confirmed by X-ray crystallography. Additionally, we have examined the coordination chemistry of these ligands and found that a variety of geometrically diverse Cu(II) and Ag(I) complexes, including interesting tri and tetrasilver complexes, can be formed. 相似文献
80.
A technique for sequential leaching of coal and fly ash resulting in good recovery of trace elements 总被引:1,自引:0,他引:1
Pauline Norris 《Analytica chimica acta》2010,663(1):39-42
Coal and fly ash contain many elements. These elements exist in different forms which may change throughout the coal combustion process. There are several processes, including X-ray techniques and leaching techniques by which studies have attempted to assess the form of a particular element in a sample. This work focuses on determining the leachability of selected elements sequentially leached in four extraction solutions: water, 1 M ammonium acetate, 3 M hydrochloric acid and 50% hydrofluoric acid. The emphasis is on evaluating the steps involved in the leaching process with the mass recovery for each element being the basis for evaluation. The total amount of each element that will leach out under the given extraction condition is presented as a fraction of the total present in the material. The materials evaluated were NIST coal and fly ash standards. The elements measured in this study include aluminum, barium, beryllium, calcium, chromium, cobalt, iron, magnesium, manganese, nickel, potassium, sodium, strontium, vanadium and zinc. 相似文献