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121.
We present a new procedure for the determination of oxygenated volatile organic compounds in samples of postoxidative effluents from the production of petroleum bitumens using dispersive liquid–liquid microextraction and gas chromatography with mass spectrometry. The eight extraction parameters were optimized for 43 oxygenated volatile organic compounds. The detection limits obtained ranged from 0.07 to 0.82 μg/mL for most of the analytes, the precision was good (relative standard deviation below 2.91% at the 5 μg/mL level and 4.75% at the limit of quantification), the recoveries for the majority of compounds varied from 70.6 to 118.9%, and the linear range was wide, which demonstrates the usefulness of the procedure. The developed procedure was used for the determination of oxygenated volatile organic compounds in samples of raw postoxidative effluents and in effluents after chemical treatment. In total, 23 compounds at concentration levels from 0.37 to 32.95 μg/mL were identified in real samples. The same samples were also analyzed in the SCAN mode, which resulted in four more phenol derivatives being identified and tentatively determined. The studies demonstrated the need for monitoring volatile organic compounds content in effluents following various treatments due to the formation of secondary oxygenated volatile organic compounds.  相似文献   
122.
The stripping voltammetry at HMDE is proposed for Cd and Pb (undesirable ingredients) determination in the natural brine (CCl >43 g L−1). Samples with so high salinity have to be significantly diluted. For ICP MS, a 105–6 times dilution is required, which disqualifies this method. The proposed procedure allows to determine Cd (0.001 μg L−1) and Pb (0.005 μg L−1) after only 100 times dilution. The thermal chloride stripping or isolation by Chelex 100 increase the quality of obtained data. The recovery study was performed. The LOQs are below recommendations related to the use of brines in balneology.  相似文献   
123.
The biological activity of bicyclic beta-lactam antibiotics depends strongly on the absolute configuration of the bridgehead carbon atom. Frelek and co-workers proposed an empirical helicity rule relating the configuration of the bridgehead carbon atom to the sign of the 220 nm band in the electronic circular dichroism (CD) spectrum of beta-lactams. Here we use synthetic organic chemistry, CD spectroscopy, and time-dependent density functional theory (TDDFT) to investigate the validity of this structure-property relationship for eight model compounds. For conformationally flexible beta-lactams, substantial thermal effects are found which must be included in calculations. To this end, we combine TDDFT calculations of CD with full quantum-mechanical Born-Oppenheimer molecular dynamics (MD) simulations for the first time. The CD spectra are sampled with ground-state density functional trajectories of up to 60 ps. The MD simulations show a surprisingly high sensitivity of the CD to the molecular conformation. On the other hand, the relation between CD and thermally averaged structural parameters is much less complex. While the helicity rule does not seem to hold for individual conformers, it is confirmed by the calculations for seven out of eight systems studied if thermally averaged CD spectra and structures are considered. Since thermal effects on CD can be larger than typical inherent inaccuracies of TDDFT, our results emphasize the need for a systematic treatment of conformational dynamics in CD calculations even for moderately flexible systems. Temperature-dependent CD measurements are very useful for this purpose. Our results also suggest that CD spectroscopy may be used as a sensitive probe of conformational dynamics if combined with electronic structure calculations.  相似文献   
124.
5-Aminolevulinic acid (ALA) is a natural precursor of protoporphyrin IX (PpIX) and heme in cells. Photodynamic therapy (PDT) utilizes a metabolic imbalance in cancer cells, leading to increased PpIX generation from exogenous ALA. Due to chemical instability of ALA in therapeutic concentrations at pH values larger than 5.0 and at high temperatures, it looses its activity by spontaneous dimerization to 2,5-dicarboxyethyl-3,6-dihydropyrazine (DHPY). ALA esters are now supplementing ALA in PDT, but little is known about their stability. We have studied the stability of ALA and its methyl ester (MAL) stored under different conditions (temperatures, pH values) by measuring their ability to generate PpIX. 100mM solutions of both compounds were found to be stable at pH 4 and at 4 degrees C. However, at pH 5.5 they lost almost 10% of the initial activity during 5days of storage at 4 degrees C. The fastest decay of ALA and MAL was seen at pH 7.4 and at 37 degrees C, and followed first order kinetics. At pH 7.4 and at 4 degrees C MAL lost its PpIX producing ability more slowly than at 37 degrees C. Our work shows that solutions should be prepared immediately before use and stored at low temperatures. The pH of stock solutions should not exceed 5.  相似文献   
125.
The oxidative polymerization of p‐phenylenediamine with silver nitrate by using various oxidant/monomer mole ratios in aqueous solutions of both acetic and nitric acid was studied experimentally and computationally. The produced micro/nanostructured conducting poly(p‐phenylenediamine)–silver composites, reaching the conductivities >104 S/cm, were characterized by conductivity and density measurements, gel permeation chromatography, transmission electron microscopy, UV–visible, FTIR, and Raman spectroscopies. The highest conductivity was 31,700 S/cm for poly(p‐phenylenediamine) base–silver (81.4 wt % Ag). The unexpected increase of conductivity after deprotonation of polymer component is discussed on the basis of interfacial electrical barriers and their removal. Theoretical study of the mechanism of p‐phenylenediamine oxidation has been based on the AM1 semi‐empirical quantum chemical computations of the heat of formation of the reaction intermediates, taking into account the influence of pH and solvation effects. Quantum chemical predictions of molecular structure of poly(p‐phenylenediamine) were correlated with spectroscopic findings. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011  相似文献   
126.
Efficient silylative coupling of linear vinyl-substituted oligo- and polysiloxanes with styrene in the presence of [RuHCl(CO)(PPh3)3] (1) and particularly [RuHCl(CO)(PCy3)2] (2) combined with copper(I) chloride is described. Treatment of styrene, with terminal or side vinyl group at siloxane skeleton catalyzed by [RuHCl(CO)(PCy3)2]/CuCl results in the quantitative and selective formation of respective silylative coupling products.  相似文献   
127.
This work presents the development of a novel construction of an integrated microelectrode array. The device was fabricated on a ceramic support, with the use of low temperature cofired ceramics technology. Model potassium-selective membranes were applied on the surface of PdAg/AgCl electrodes formed on the ceramic substrate. The obtained microsensors exhibited very good repeatability, reproducibility, and sensitivity. The array of microelectrodes covered with polymeric layers of various selectivities was applied as an electronic tongue to differentiate between various diet supplements.  相似文献   
128.
Optimized facile syntheses and highly desirable spectroscopic properties of two isomorphic fluorescent pyrimidines, comprising a 1,2,4‐triazine motif conjugated to a thiophene ( 1 a ) or a furan ( 1 b ), are described. Although structurally related to their 5‐modified uridine counterparts, these modified 6‐aza‐uridines reveal dramatically improved fluorescence properties and a remarkable sensitivity to polarity and pH changes. The thiophene derivative 1 a has an absorption maximum around 335 nm, which upon excitation yields visible emission with a polarity‐sensitive maximum and fluorescence quantum yield ranging from 415 nm (Φ=0.8) to 455 nm (Φ=0.2) in dioxane and water, respectively. Nucleoside 1 a also displays susceptibility to acidity. Correlating emission intensity and solution pH yields a pKa value of 6.7–6.9, reasonably close to physiological pH values. The results illustrate that highly sought‐after fluorescence features (brightness and responsiveness) are not necessarily the trait of large fluorophores alone, but can be observed with probes that meet stringent isomorphic design criteria.  相似文献   
129.
The paper presents a thorough characteristics of Langmuir monolayers formed at the air/water interface by a polyene macrolide antibiotic-nystatin. The investigations are based on the analysis of pi/A isotherms recorded for monolayers formed by this antibiotic at different experimental conditions. A significant part of this work is devoted to the stability and relaxation phenomena. It has been found that nystatin forms at the air/water interface monolayers of the LE state. A plateau region, observed during the course of the isotherm compression, is suggested to be due to the orientational change of nystatin molecules from horizontal to vertical position. Quantitative analysis of the desorption of the monolayer material into bulk water indicates that the solubility of nystatin monolayers increases with surface pressure. At low surface pressures, the desorption of nystatin from a monolayer is controlled both by dissolution and by diffusion. However, at the plateau and in the post-plateau region, the desorption does not achieve a steady state and the monolayer is less stable than in the pre-plateau region. However, the presence of membrane lipids, even at a low mole fraction, considerably increases the stability of nystatin monolayers. This enables the application of the Langmuir monolayer technique to study nystatin in mixture with cellular membrane components, aiming at verifying its mode of action and the mechanism of toxicity.  相似文献   
130.
Ciosek P  Wróblewski W 《Talanta》2006,69(5):1156-1161
Flow-through electronic tongue based on miniaturized solid-state potentiometric sensors has been developed. A simple technique, i.e. membrane solution casting on the surface of the planar Au transducers was applied for the preparation of classical ion-selective and partially selective microelectrodes, introduced in the flow-through sensor array. The performance of the designed electronic tongue was tested in the qualitative analysis of various brands of beer. Samples of the same brand of beer but with different manufacture dates, originating from different manufacture lots, have been applied in the studies. The combination of PLS and ANN techniques allowed the discrimination between different brands of beer with 83% of correct classifications.  相似文献   
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